search

Active clinical trials for "Depressive Disorder"

Results 1391-1400 of 5015

A Study of Vilazodone in Pediatric Patients With Major Depressive Disorder

Major Depressive Disorder

The purpose of this study is to evaluate the long-term safety and tolerability of vilazodone for the treatment of MDD in pediatric outpatients (7-17 years).

Completed8 enrollment criteria

A Trial on Metacognitive Training for Depression (D-MCT)

Depression

The purpose of the present randomized-controlled trial is to investigate the efficacy of Metacognitive Training for Depression (D-MCT), a new low-threshold, modular group intervention.

Completed5 enrollment criteria

Health At Every Size and Acceptance and Commitment Therapy vs. Behavioral Weight Loss for Obesity...

DepressionObesity

The primary aim of this project is to conduct a randomized controlled pilot study evaluating the feasibility and potential effectiveness of a newly developed combined Health At Every Size and Acceptance and Commitment Therapy (HAES/ACT) treatment, known as Accept Yourself! compared to a commercial behavioral weight loss program, Weight Watchers (WW). Obese women (BMI ≥ 30) with Major Depressive Disorder will be randomly assigned to one of these two treatments. Depression, physical health, and other psychosocial outcomes will be assessed prior to treatment, at post-treatment, and at 3, 6, 9, and 12-month follow up assessments.

Completed13 enrollment criteria

Therapy With an Oxytocin Adjunct for Major Depression

Depressive Disorder

This study evaluates the addition of intranasal oxytocin to the treatment of Major Depression using interpersonal psychotherapy. Half of the participants will receive a placebo adjunct to interpersonal psychotherapy, and the other half will receive oxytocin.

Completed11 enrollment criteria

The Effects of tDCS on Depressive Symptoms,Neurocognitive Function and HRV in Unipolar Depression...

Depressive DisorderMajor3 more

The study aimed to investigate whether transcranial direct current stimulation could improve depressive symptoms, neurocognitive function and modulate heart rate variability in unipolar and bipolar depression.

Completed6 enrollment criteria

Lumateperone Monotherapy for the Treatment of Bipolar Depression Conducted Globally

Bipolar Depression

The study will evaluate the efficacy and safety of ITI-007 in a randomized, double-blind, parallel-group, placebo-controlled, multi-center study in patients diagnosed with Bipolar I or Bipolar II disorder having a major depressive episode.

Completed7 enrollment criteria

A Study of Rapastinel as Adjunctive Therapy in Major Depressive Disorder (RAP-MD-03)

Depressive DisorderMajor

This study will evaluate the efficacy, safety, and tolerability of rapastinel 450 milligrams (mg) compared to placebo adjunctive to antidepressant therapy (ADT) in patients with major depressive disorder (MDD) who have a partial response to ADT.

Completed14 enrollment criteria

A Closed-loop Assessment and Treatment Platform for Unipolar Depression and Anxiety

Major Depressive Disorder

Specific Aim 1: Finalize development of the closed-loop strategy in the MMT application. Specific Aim 2: Evaluate the acceptability and feasibility of the MMT application with the target population to prepare for a large-scale efficacy trial.

Completed15 enrollment criteria

TMS for Adults With Autism and Depression

Autism Spectrum DisorderDepression2 more

The goal of this proposal is to investigate whether a standard rTMS protocol for depression, including multiple sessions applied to left dorsolateral prefrontal cortex (DLPFC) results in reduction of depressive symptoms for adult patients with ASD and MDD (Aim 1). The secondary goal is to investigate and whether there is any beneficial reduction in the core symptoms of autism (Aim 2).

Completed22 enrollment criteria

Augmentation of Treatment-Resistant Depression With An Analog of the Neuroactive Steroid Allopregnanolone...

Major Depressive Disorder

Major depressive disorder (MDD) is highly prevalent and nearly 70% of individuals with MDD do not respond to standard antidepressant therapies despite adequate dosing. An effective and well-tolerated antidepressant augmentation therapy would have important clinical and public health implications. Neuroactive steroid hormones are known to directly activate neurotransmitter receptors in the brain, and thus are potential candidates for augmentation therapies to enhance the effect of traditional antidepressants. The investigators hypothesize that administration of an allopregnanolone analog in women with treatment-resistant depression will improve depressive symptoms.

Completed12 enrollment criteria
1...139140141...502

Need Help? Contact our team!


We'll reach out to this number within 24 hrs