Safety and Efficacy Study of Vilazodone and Discovering Genetic Markers Associated With Response...
Major Depressive DisorderThe purpose is to evaluate the safety and usefulness of the investigational drug, vilazodone in depression.
A United States Extension Study of Corlux for Recurrent Psychotic Symptoms in Psychotic Major Depression...
Depressive DisorderMajorCorlux (mifepristone) is a new medication that modulates the body's use of a hormone called cortisol. Under normal conditions, cortisol and other hormones are created by the body in response to physical and emotional stress, triggering a healthy stress response. People who suffer from psychotic major depression may have unusually high levels of cortisol circulating within them or abnormal patterns of cortisol levels, overloading the stress response mechanism and causing symptoms of psychosis such as delusional thoughts or hallucinations. If Corlux can keep the body's cortisol receptors from being overloaded, the stress response system may return to normal function, which may result in improvement of symptoms. The purpose of this study is to allow patients who have already participated in an earlier 8 week study of Corlux versus placebo (an inactive pill) to receive additional courses of treatment with Corlux periodically if a psychotic episode should reappear during a period of one year.
A Randomized Double Blind Study Evaluating Duloxetine in Outpatients With MDD and Pain
Depressive DisorderMajorTo determine the efficacy of Duloxetine vs. placebo on pain as determined by change in the Brief Pain Inventory (BPI) from baseline over 8 weeks of treatment
Effects of Psychoeducation of Relatives to Patients With Serious Mental Illness
Mental DisorderDepressive Disorder1 moreThe purpose of this study is to determine the effects of psychoeducation for relatives to patients with serious mental illness.
Memantine Treatment for Improving Rehabilitation Outcomes and Preventing Depression in Older Adults...
DepressionThis study will evaluate the effectiveness of memantine in improving rehabilitation outcomes and preventing major depressive disorder in older adults who have been admitted to a rehabilitation hospital for a hip fracture or cardiopulmonary condition.
Safety and Effectiveness of S-adenosyl-l-methionine (SAMe) for the Treatment of Major Depression...
DepressionThe purpose of this study is to determine the safety and effectiveness of s-adenosyl-l-methionine (SAMe) in treating major depression.
Study Of GW679769 In Major Depressive Disorder
Depressive DisorderMajor1 moreThis is a placebo-controlled, fixed dose study that will evaluate the efficacy and safety of GW679769 in subjects with major depressive disorder.
Study of a Repetitive Transcranial Magnetic Stimulation (rTMS) Device for the Treatment of Major...
Major Depressive DisorderThis trial will test the safety and efficacy of a rTMS device for the treatment of major depressive disorder (MDD). It is hypothesized that rTMS will have an antidepressant effect. It is a 10-week, randomized, sham-controlled, multicenter trial in outpatients recruited in both academic and private research centers. It is comprised of three major phases: pre-study screening, acute treatment, and post-treatment taper. Eligible patients will be randomized to one of two rTMS treatment groups. One group will receive active rTMS treatment and one will receive an inactive, or sham, treatment. Each treatment takes about 45 minutes and is done on an outpatient basis. All trial related medical care is provided at no cost to the participant.
Study of Escitalopram in Adult Patients With Major Depressive Disorder
Major Depressive DisorderEscitalopram is the S-enantiomer of citalopram. Both escitalopram and citalopram are selective serotonin reuptake inhibitors (SSRIs) and are used to treat depression in adults. This study is designed to evaluate the efficacy, safety, and pharmacoeconomics of escitalopram and an active comparator in patients with major depressive disorder.
Triiodothyronine (T3) Supplementation in the Treatment of Bipolar and Unipolar Depression.
Major DepressionBipolar Disorder1 moreThe purpose of this project is to determine whether concurrent treatment of patients with major depression (unipolar or bipolar) with triiodothyronine (T3) and sertraline, will lead to a stronger and/or more rapid antidepressant effect than treatment with sertraline alone.