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Active clinical trials for "Depressive Disorder"

Results 2681-2690 of 5015

Cognitive Behavioral Therapy Delivered Over the Internet for Women With Postpartum Depression

Postpartum Depression

This study will develop and test a Web-based program to treat women with postpartum depression.

Completed8 enrollment criteria

The Role Of Omega-3 Fatty Acids In Adolescent Depression

Depressive DisorderMajor

The purpose of this study is to examine the effects of a 10-week Omega-3 Fatty Acid treatment phase on brain chemistry of adolescents with major depressive disorder (MDD) using proton magnetic resonance imaging.

Completed16 enrollment criteria

Self-guided Depression Treatment on Long-duration Spaceflights: A Continuation Study

Depression

Use of a computer-based treatment will reduce level of depression.

Completed21 enrollment criteria

Psychosocial Treatment for Women With Depression and Pain

Pelvic PainDepression

Patients with depression and pain have poorer outcomes in response to depression treatments than depressed patients without pain. While psychotherapy treatment studies have demonstrated improvement in pain and depression, no psychosocial interventions have been developed and tested prospectively specifically for patients with both conditions. Interpersonal psychotherapy (IPT), an effective treatment for depression, has been adapted successfully for physically ill patients and demonstrates good adherence, treatment satisfaction, and depression outcomes. The investigators propose to test a modified form of IPT-P for depressed patients with co-morbid pain.

Completed11 enrollment criteria

Depression Outcomes Study of Exercise

Unipolar Depression

This pilot study may yield important research findings on how to adapt exercise treatment for depression among adolescents. Potential public health benefits from this study include a reduction of adolescent depression and problems associated with untreated depression in young adults including suicide, substance abuse, cigarette smoking, teen pregnancy, impaired psychosocial functioning and school failure. In addition, because this study prescribes physical activity as a treatment for depression, additional public health benefits may include a reduction in chronic diseases such as obesity, diabetes and heart disease, all of which are associated with sedentary behavior.

Completed15 enrollment criteria

Using a Text-message System to Engage Depressed Adolescents in Cognitive-behavioral Therapy Homework...

Major Depressive DisorderCognitive Behavior Therapy1 more

The primary goal of the pilot is to test the feasibility and utility of using a text-messaging system to engage adolescents in improved homework adherence during cognitive-behavioral therapy (CBT) for major depressive disorder.

Completed5 enrollment criteria

Functional Change and Efficacy of Duloxetine in Patients With Co-Morbid Depression & Soft Tissue...

Major Depressive DisorderSoft Tissue Discomfort Syndrome1 more

The objective of this study is to determine the time course of duloxetine efficacy on the symptoms of Major Depressive Disorder (MDD)and on the symptoms of Soft Tissue Discomfort Syndrome(STDS) via use of 24-hour Actigraph™ measures. We hypothesize that there will be a reduction in both MDD and STDS symptoms in MDD patients with co-morbid STDS symptoms. We further hypothesize that there will be a rapid improvement in functional outcome ratings and 24-hour activity in MDD patients with co-morbid STDS symptoms which may occur even before the antidepressant effect is observed.

Completed15 enrollment criteria

Evaluation of a Diabetes-specific Cognitive Behavioural Treatment for Subthreshold Depression

Depressive SymptomsDiabetes Mellitus

This work is supported by the "Kompetenznetz Diabetes mellitus (Competence Network for Diabetes mellitus)" funded by the Federal Ministry of Education and Research (FKZ 01GI0809). Approximately one third of diabetic patients has elevated depressive symptoms. The majority of these patients are suffering from a subthreshold depression. In spite of the fact that subthreshold depression has an equivalent negative impact on the prognosis of diabetes as clinical depression, there is no specific intervention tool. The main objective of this project is to develop a diabetes specific cognitive behavioural treatment (DS-CBT) for diabetic patients with subthreshold depression. In a randomized trail DS-CBT is compared to standard diabetes education. A total of 188 diabetic patients will be recruited and randomly assigned to the two treatment conditions. The expected main outcome is the reduction of subthreshold depression under DS-CBT in a 12 month follow up. Secondary variables are improvement of glycaemic control, quality of life, diabetes self-management as well as reduction of health care costs and modification of inflammatory parameters.

Completed12 enrollment criteria

Escitalopram in Adult Patients With Major Depressive Disorder

Major Depressive Disorder

This is a short-term study to evaluate the efficacy, safety, and tolerability of escitalopram in adult patients (18 to 65 years of age) with moderate to severe depression. Patients completing the study may be eligible to enter a long-term open-label extension study with escitalopram.

Completed6 enrollment criteria

Randomised Placebo-controlled Duloxetine-referenced Efficacy and Safety Study of 2.5, 5 and 10 mg...

Major Depressive Disorder

The purpose of the study is to evaluate the efficacy and the tolerability of three fixed doses of Vortioxetine in order to establish the appropriate clinical effective dose range in the treatment of Major Depressive Disorder (MDD).

Completed8 enrollment criteria
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