Program ACTIVE II: Behavioral Depression Treatment for Type 2 Diabetes
Type2 DiabetesDepressionProgram ACTIVE II is a depression treatment study sponsored by the National Institutes of Health, Indiana University, Ohio University and West Virginia University. The purpose of this study is to test the effectiveness of two forms of treatment for depression for adults with type 2 diabetes: talk therapy (counseling) and exercise. Both of these forms of treatment have been proven to be effective in helping people with depression alone. In this study, the investigators will test to see if both of these approaches may be more effective in helping people live depression-free compared to talk therapy, exercise or usual care alone.
A Study of Duloxetine (LY248686) in Japanese Children and Adolescents With Depressive Disorder
Depressive DisorderThe purpose of this study is to determine the efficacy of duloxetine hydrochloride versus placebo in the treatment of Japanese children and adolescents with depressive disorder.
Relative Bioavailability (RBA) Study of LY03005 vs Pristiq®
Major Depressive DisorderThe objective of this study is to evaluate relative bioavailability between 80 mg LY03005 oral tablets and 50 mg Pristiq® oral tablets after a single dose of each drug in a cross-over 2-period design under fasting condition in healthy subjects between 18 and 50 years of age.
Home-administered tDCS for Treatment of Depression
Unipolar DepressionTreatment Resistant DepressionThis study will determine the safety and efficacy of home administered tDCS in adults with unipolar depression. The device used to administer tDCS will be the Soterix Medical 1X1 mini-CT. 32 tDCS sessions of 30 minutes each will be delivered over 10 weeks.
Comparing Efficacy of Optimal Treatment and Conventional Treatment for Major Depressive Disorder...
Major Depressive DisorderComparison of efficacy treatment (respond, remission) between the optimized treatment group (dose adjustment or early change other drug based on the change of total score HAM-D 17) and the routine treatment group (start with the lowest effective dose and adjust dose slowly) for depressed patients in Viet Nam
Adaptation of a Behavioral Activation Treatment to Treat Depression in Autistic Adults
Autism Spectrum DisorderDepression1 moreThe present study aims to adapt and evaluate the feasibility of the BeatIt behavioral activation intervention for people with intellectual disabilities and low mood to be implemented with autistic individuals, with and without intellectual disabilities.
What is the Effect of Aerobic Exercise on Depression in Geriatric Individuals Diagnosed With Depression?...
Aerobic ExerciseDepression2 moreThis study was planned to examine the effect of aerobic exercises on depression in geriatric individuals with a diagnosis of depression.
A Single and Multiple Ascending Dose Trial of CVL-354 in Healthy Participants
Major Depressive DisorderThis is a 2-part, double-blind, randomized, placebo-controlled, first-in-human trial evaluating a single ascending dose (4-way crossover, Part A) and multiple ascending doses (Part B) of CVL-354.
A Study of SLS-002 (Intranasal Racemic Ketamine) in Adults With Major Depressive Disorder at Imminent...
Depressive DisorderMajor1 moreThe purpose of the study is to evaluate the efficacy, safety, and tolerability of SLS-002 (intranasal racemic ketamine) in addition to standard of care on symptoms of Major Depressive Disorder (MDD) and suicidality, in participants who are assessed to be at imminent risk for suicide, as measured by the change from baseline on the Montgomery-Asberg Depression Rating Scale (MADRS) total score at 24 hours post first dose.
Electroconvulsive Therapy Amplitude Titration
Major Depressive DisorderThis study is focused on advancing ECT treatment for older adults with depressive disorders by refining neuromodulation stimulus parameters to improve efficacy and cognitive safety.