Study Comparing Outcomes for Patients With Treatment Resistant Depression Who Receive VNS Therapy...
DepressionThis is a postmarket medical device study. The objective of this study is to compare the safety and effectiveness of Vagus Nerve Stimulation (VNS) Therapy administered at different amounts of electrical charge for the treatment of patients with treatment-resistant depression (TRD).
Exercise to Treat Depression in Individuals With Coronary Heart Disease
DepressionHeart DiseasesSome individuals with coronary heart disease (CHD) suffer from depression and use antidepressant medications to reduce symptoms. However, preliminary research has shown that exercise may be a more effective way to treat depression in these individuals. The purpose of this study is to evaluate the effects of exercise in reducing depression and improving heart function in individuals with CHD.
Maintenance Treatment of Bipolar Depression
Bipolar DisorderDepressionThis study will compare two different antidepressant treatment regimens to determine which is more effective in reducing symptoms of bipolar depression.
Efficacy of Seroquel SR in Combination With an Antidepressant in Treatment of Major Depressive Disorder...
Major Depressive DisorderTo evaluate the efficacy of quetiapine fumarate sustained release (Seroquel SR™) in combination with an antidepressant versus an antidepressant alone in patients with Major Depressive Disorder. PLEASE NOTE: Seroquel SR and Seroquel XR refer to the same formulation. The SR designation was changed to XR after consultation with FDA.
A 24-52-week Study to Evaluate the Long-term Efficacy and Safety of Saredutant in Patients With...
Depressive DisorderThe purpose of the study is to evaluate the long-term efficacy and safety of Saredutant in patients with depression. The primary objective is to evaluate the efficacy and safety of Saredutant 100 mg once daily compared to placebo in the prevention of relapse of depressive symptoms in outpatients with major depressive disorder who achieved an initial response to 12 weeks of open-label treatment with Saredutant.
Identification and Therapy of Postpartum Depression
DepressionThis study will evaluate the effectiveness of a telephone-based depression screening and care management program in treating depression in postpartum women.
Sedating Antidepressant Improves Driving Safety in Patients With Major Depressive Disorder
DepressionExcessive Daytime SleepinessThis concurrent, two-part study will: I) Using overnight sleep recordings, evaluate the short- and long-term sleep-promoting effects of the antidepressant mirtazapine (Remeron) in patients who have been prescribed this medication for major depressive disorder and sleep disruption. II) Investigate the psychomotor performance of depressed patients using driving simulation testing before and during treatment with mitrazapine.
Study Evaluating the Effects of DVS SR and Duloxetine on the Pharmacokinetics of Desipramine in...
DepressionDepressive Disorder2 moreThe purpose of this study is to evaluate the effects of multiple doses of DVS SR and duloxetine on the pharmacokinetics of a single dose of desipramine in healthy subjects.
Evaluating the Effectiveness of Brief Interpersonal Psychotherapy for Pregnant Women With Depression...
DepressionThis study will compare the effectiveness of brief interpersonal psychotherapy versus standard treatment for pregnant women with depression.
Memory Functioning and Antidepressant Treatment
DepressionMajor Depressive DisorderMajor Depressive Disorder (MDD) is a serious illness associated with considerable morbidity, risk of suicide and adverse social consequences (Montgomery et al., 1994a). Cognitive impairment is one of the three major symptom areas of MDD. Specifically, memory impairment and concerns are one of the most commonly reported complaints in MDD. While antidepressant (AD) treatments vary a great deal in their propensity to cause cognitive impairment, there remains a paucity of empirical evidence on the effects of AD treatment on neuropsychological indices of memory functioning in non-geriatric depressed individuals. Hence, comparative effects of various AD drugs on memory functioning remain unclear.The aim of this study is to evaluate multiple aspects of memory functioning (short-term, working memory, verbal, non-verbal, spatial and prospective memory) of MDD patients before and after 8 weeks of antidepressant treatment with bupropion XL or escitalopram.