Behavioral Activation and Emotion-focused Interventions in the Treatment of Depression
DepressionThe study is a single-case intervention study, evaluating effects of the treatment Behavioral activation and emotion-focused interventions for depression. Research question and hypothesis What is the effect of behavioural activation and emotion-focused interventions on patients' ratings of depressive symptoms, behavioural activation and emotion regulation difficulties? What is the effect of behavioural activation and emotion-focused interventions on patients' overall psychiatric state, with regards to ratings of anxiety, quality of life, level of functioning? How does patient ratings of behavioural activation and emotion regulation difficulties and skills change during the course of treatment, in relation to treatment/session content?
Psilocybin in Co-occuring Major Depressive Disorder and Borderline Personality Disorder
Borderline Personality DisorderMajor Depressive DisorderThe primary objective of the study is to evaluate the safety and efficacy of psilocybin in adults with major depressive disorder (MDD) and borderline personality disorder (BPD).
Decoding and Modulating Affective Brain States
RuminationMajor Depressive Disorder1 moreGenerating personalized brain signatures of negative emotion along with personalized brain stimulation protocols to disrupt these patterns. We plan to use fMRI and muscle activity data to determine negative affect maps for each participant. We will then try a variety of patterned repetitive transcranial magnetic stimulation sequences while recording fMRI which will be the basis of two sessions of 3-day individualized brain stimulation designed to reduce negative affect.
Beyond Efficacy- Eliciting Preference for Face-to-face and Internet-based Psychotherapy Among People...
DepressionThe aim of this study is to strengthen the evidence base of clients' preferences of psychotherapy and to close the described literature gaps so as to inform public health resource reallocation and implementation of psychological services. The investigators aim to address the following research questions: Which psychological service attributes exert the most influence on the service use decisions? Can respondents be represented by latent classes on the basis of similar preference profiles? Which attributes exert the most influence on the service utilization decisions of each latent class? Will people with depression adopt Internet-based psychotherapy considering the long waiting time and high cost of conventional face-to-face psychotherapy? To systematically address the above questions, specific research objectives are defined as follows: to examine the relative importance of a series of characteristics of psychological services (e.g., delivery modality, waiting time, out-of-pocket service fee, anonymity and referral methods) on the choices of psychological service using DCE. to identify segments of people with depression with different service preferences using latent class model, because the relative weighting of service preferences may vary with demographic (e.g., gender, age, socioeconomic status, depression severity) and psychological characteristics (e.g., help seeking stigma); and since DCEs need to be translated into improved services to be truly useful, and with reference to emerging interest in the development of digital mental health service for people with depression to solve the issue of long waiting time and cost in face-to-face psychotherapy, using a series of statistical simulations, we aim to estimate the percentage of people with depression in each latent class segment who would use psychotherapy with pre-defined treatment attributes packages.
Basal Plasma Lithium Levels and Suicidal Events
Major Depressive DisorderSuicidal Behavior1 moreSuicidal behavior is a major public health issue and there are currently no specific treatments for it. However, lithium, the reference treatment for bipolar disorder, have been shown to be effective in preventing suicidal risk. Apart from drug treatments, lithium is present in our environment and its levels varies from one individual to another, depending, especially, on diet. Knowing that patients with a mood disorder generally have a poor lifestyle and a less rich and varied diet than the general population, variations in basal lithium levels can be expected in these patients.
Integrating a Suite of Mental Health Apps for Depression in a Healthcare Setting
DepressionAnxietyThe purpose of this study is to evaluate the implementation of IntelliCare as a frontline intervention within health care settings.
Personalized Escitalopram Dosing in Patients With Depression
Depressive DisorderMajorThe aims of this study are to: Determine the proportion of participants who are underdosed or overdosed under recommended dosing regimen of escitalopram for the depression treatment (10 mg/day) Determine and quantify clinical benefits of personalized escitalopram dosing regimen based on the escitalopram blood level monitoring Retrospectively estimate whether the information on CYP2C19 genotype is useful in the prediction of escitalopram blood level.
Behavioral Activation for Depression Through Virtual Reality
DepressionEvaluate the effectiveness of a brief, virtual reality intervention for depressed mood
A Remote Electronically Delivered Integrated Care Pathway: A Feasibility Study
Major Depressive DisorderThis is a one-armed observational study and feasibility trial of a remote electronically-delivered integrated care pathway for the treatment of adolescents. Eligible participants are between the ages of 13 and 18, inclusive, who have a primary diagnosis of major depressive disorder. Outcomes of interest are recruitment rates and participation in pathway components, including: appointments, measure-completion and use of electronically-delivered cognitive behavioural therapy.
Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT)
DepressionHIV-1-infection1 moreThe purpose of this randomized controlled trial is to understand how a cognitive-behavioral treatment (a form of psychological treatment) for depression changes the gut microbiome (micro-organisms that regulate the health of the gut), immune system, and the brain functioning in people living with HIV.