A Study of Nab-paclitaxel-based Doublet as First Line Therapy in Patients With Cancer of Unknown...
Unknown Primary TumorsAgnostos Trial is a multicentric phase 2 randomized trial with a 'pick-the-winner design' in chemonaive patients with cancer of unknown primary. It will assess the efficacy of the two best active single agent - carboplatin or gemcitabine - added to an innovative taxane back bone (nab-Paclitaxel). Agnostos trial is a part of a larger clinical and translational initiative to improve the outlook of patients with cancer of unknown primary through evaluation of novel chemotherapeutic regimens.
Nivolumab/Ipilimumab in Second Line CUP-syndrome
Cancer of Unknown Primary SiteTo compare the efficacy of nivolumab plus ipilimumab in subjects with high vs. Intermediate/low TMB poor-prognosis CUP (non-specific subset) who are relapsed or refractory to platinum-based first-line chemotherapy. To evaluate the efficacy of nivolumab plus ipilimumab in subjects with poor-prognosis CUP (non-specific subset) who are relapsed or refractory to platinum-based first-line chemotherapy
Paclitaxel/Carboplatin With or Without Cetuximab in CUP
NeoplasmsUnknown Primary1 moreThe purpose of this study is to determine whether an addition of cetuximab to carboplatin/paclitaxel can improve efficacy in comparison to carboplatin/paclitaxel in patients with carcinoma of unknown-primary.
Chemotherapy in Treating Patients With Cancer of Unknown Primary Origin
Carcinoma of Unknown PrimaryRATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known which combination chemotherapy regimen is more effective for cancer of unknown primary origin. PURPOSE: Randomized phase III trial to compare the effectiveness of two different regimens of combination chemotherapy in treating patients with cancer of unknown primary origin.
Combination Chemotherapy in Treating Patients With Metastatic Cancer of an Unknown Site of Origin...
Carcinoma of Unknown PrimaryRATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known which combination chemotherapy regimen is more effective for metastatic cancer of an unknown site of origin. PURPOSE: Randomized phase III trial to compare the effectiveness of two combination chemotherapy regimens in treating patients who have metastatic cancer of an unknown site of origin.
Pro-Active Genetic Testing in Patients With Solid Tumors, Inherit Study
Breast CarcinomaDigestive System Neoplasm9 moreThis phase I trial collects blood samples to investigate the prevalence of changes in genes (genetic mutations) in solid tumor patient populations seeking care at Mayo Clinic Embedded Cancer Center at St. Vincent's Riverside. This may help doctors better understand and/or treat others who have genetic mutations.
Phase 2 Study of Gemcitabine and Docetaxel Combination Chemotherapy in Patients With Carcinoma of...
Carcinoma of Unknown PrimaryIt's a phase 2, single arm study of gemcitabine an docetaxel combination in patients with carcinoma of unknown primary.
Comparing of Modified Wet Suction Technique and Dry Suction Technique for EUS-FNA of Solid Occupying...
Pancreas NeoplasmsLymphatic Metastasis6 moreThe purpose of this study is to compare the diagnosis accuracy of modified wet suction technique and 5ml dry suction technique on solid occupying lesions.
Cost-effectiveness Study of miRview™ Mets in Patients With Cancer of Unknown Primary (CUP)
NeoplasmsUnknown PrimaryThe aim of the study is in cancer of unknown primary (CUP) patients, to compare the cost-effectiveness of miRview™ mets test with conventional work-up in identifying the primary tumor site.
Prospective Multi-center, Single Blinded, Randomized, Controlled Trial of EUS-FNB and EUS-FNA on...
Pancreas NeoplasmsLymphatic Metastasis2 moreThe purpose of this study is to compare the diagnosis accuracy of FNA and FNB biopsy on pancreatic, retroperitoneal, mediastinum and pelvic cavity solid occupying lesions.