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Active clinical trials for "Urinary Bladder Neoplasms"

Results 121-130 of 1252

Study of Erdafitinib Intravesical Delivery System for Localized Bladder Cancer

Urinary Bladder NeoplasmsReceptors1 more

The purpose of the study in Part 1 (dose escalation) is to determine the recommended Phase 2 dose(s) (RP2D[s]) and in Part 2 (dose expansion) is to determine the safety of Erdafitinib Intravesical Delivery System administered at the RP2D(s).

Recruiting10 enrollment criteria

IO102-IO103 in Combination With Pembrolizumab as First-line Treatment for Patients With Metastatic...

Lung Cancer Non Small CellHead and Neck Squamous Cell Carcinoma1 more

A Phase II Multi-Arm (basket) Trial Investigating the Safety and Efficacy of IO102-IO103 in Combination with pembrolizumab, as First-line Treatment for Patients with Metastatic Non-Small Cell Lung Cancer (NSCLC), Squamous Cell Carcinoma of Head or Neck (SCCHN), or Metastatic Urothelial Bladder Cancer (mUBC)

Recruiting56 enrollment criteria

Study of 2141-V11 in People With Non-muscle Invasive Bladder Cancer That Did Not Respond to Standard...

Non-muscle Invasive Bladder Cancer

The purpose of this study is to test the safety of the study drug 2141-V11 in people whose NMIBC did not respond to standard treatment, and who will not have the standard surgical procedure to remove the bladder. The researchers will test different doses of 2141-V11 to see which dose is safest in people. The researchers will also do tests to see how the body absorbs, distributes, and gets rid of 2141-V11. This study is one of the first to test 2141-V11 in people, and the first to test 2141-V11 delivered through a catheter into the bladder.

Recruiting73 enrollment criteria

Trial of Local Cystoscopic Injection of Tremelimumab Plus Systemic Durvalumab for High Risk Non-Muscle...

Bladder CancerHigh-Risk Cancer3 more

We will conduct a Phase I trial testing whether local cystoscopic injection of tremelimumab into the bladder wall in combination with systemic administration of durvalumab in localized bladder cancer will stimulate an effective anti-tumour immune response with minimal systemic immune response and clinical toxicity.

Recruiting73 enrollment criteria

A Study of Intravesical Enfortumab Vedotin For Treatment of Patients With Non-muscle Invasive Bladder...

Urinary Bladder NeoplasmsCarcinoma in Situ3 more

This study will test a drug called enfortumab vedotin in participants with a type of bladder cancer called non-muscle invasive bladder cancer (NMIBC). This study will also evaluate what the side effects are and if the drug works to treat NMIBC. A side effect is anything a drug does to your body besides treating your disease. In this study enfortumab vedotin will be put into the bladder using a catheter. A catheter is a thin tube that can be put into your bladder.

Recruiting16 enrollment criteria

BCG in Combination With Durvalumab in Adult BCG-naïve, High-risk NMIBC Participants

Non-Muscle- Invasive Bladder Cancer

The purpose of this study is to assess the safety, tolerability, and efficacy profile of durvalumab + BCG (induction and maintenance) combination therapy in adult United States participants with a histologically confirmed diagnosis of high-risk non-muscle-invasive bladder cancer (NMIBC), who have received no prior systemic therapy for NMIBC, and who are BCG-naïve.

Recruiting26 enrollment criteria

Safety and Efficacy of FE 999326 Administered Intravesically to Japanese Subjects With High-grade,...

Bladder Cancer

To evaluate the safety and efficacy of FE 999326 in Japanese subjects with high-grade, BCG unresponsive NMIBC.

Recruiting21 enrollment criteria

Study of VB4-845 Injection for Treating Patients With Non-muscle Invasive Bladder Cancer

Non-Muscle Invasive Bladder Cancer

Because of the high risk for development of muscle invasive disease, cystectomy is recommended for CIS, high-grade Ta and T1 patients who experience disease recurrence following intravesical therapy. VB4-845 injection is an experimental agent that may provide an alternative to cystectomy

Recruiting17 enrollment criteria

Safety, Tolerability and Pharmacokinetics of Oral CPL304110, in Adult Subjects With Advanced Solid...

Gastric CancerBladder Cancer5 more

The purpose of the study is to determine to evaluate safety and tolerability of CPL304110 when administered once daily to adults with advanced solid malignancies.

Recruiting32 enrollment criteria

Electromotive Mitomycin-C (EMDA-MMC) in Preventing Recurrences in High-risk Non-muscle-invasive...

Bladder Cancer

Disease recurrence and progression is a major issue in high risk non-muscle-invasive bladder cancer (NMIBC). The current study compares two adjuvant instillation therapies in the treatment of high risk NMIBC. After resection of the tumour(s), patients will receive either traditional regimen of Bacillus Calmette-Guérin (BCG) instillations or combination treatment consisting of sequential BCG-instillations and mitomycin C instillations administered with electromotive drug administration (EMDA) device.

Recruiting22 enrollment criteria
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