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Active clinical trials for "Urinary Bladder, Overactive"

Results 311-320 of 730

Trial of Maintenance Therapy With Posterior Tibial Nerve Stimulation for Overactive Bladder

Overactive Bladder Syndrome

This study has 2 parts. Part 1 is a 12-week observational study of weekly Posterior Tibial Nerve Stimulation (PTNS) treatment for women with overactive bladder. Part 2 is a randomized, controlled trial of monthly maintenance PTNS therapy versus no therapy in subjects who were successfully treated by PTNS in Part 1. Part 1: 12-week observational study of weekly PTNS treatment. The primary aim of Part 1 is to determine the efficacy of a 12-week course of PTNS in the treatment of overactive bladder. Secondary aims are to determine the changes in voiding frequency and quality-of-life measures after the 12-week treatment. Part 2: Randomized, controlled study of monthly PTNS compared to no PTNS after 12-week treatment The primary aim is to determine time-to-failure after 12 weeks of PTNS in subjects who receive maintenance therapy compared to those who do not, in order to ascertain if there is a need for maintenance therapy after 12 weeks of PTNS. The investigators' secondary aims are to compare the long-term efficacy and quality of life impact in patient receiving maintenance PTNS compared to those that do not and to determine the efficacy of rescue maintenance PTNS in subjects who have symptom recurrence in the no maintenance therapy arm. Hypothesis: There will be no difference in time to failure between women randomized to monthly maintenance PTNS compared to no maintenance PTNS.

Completed12 enrollment criteria

Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Neurogenic Overactive Bladder...

Overactive Bladder

The purpose of this study is to assess the safety and effectiveness of botulinum toxin type A in treating overactive bladder in spinal cord injury or multiple sclerosis patients.

Completed5 enrollment criteria

A Study Of GW679769 Compared To Placebo In Women With Overactive Bladder

IncontinenceUrinary and Urinary Bladder2 more

This is a Phase IIa study to evaluate the efficacy, safety and tolerability of GW679769 vs placebo on symptoms of urgency with urge incontinence, frequency and nocturia associated with overactive bladder in women.

Completed16 enrollment criteria

Dose Ranging Study Of Solabegron Versus Placebo In Female Patients With Overactive Bladder Symptoms...

Overactive Bladder

This study will test the effectiveness and safety of two doses of solabegron against placebo in reducing the symptoms of overactive bladder.

Completed19 enrollment criteria

A Study of Solifenacin With Bladder Training Versus Solifenacin Alone in Patients With Overactive...

Overactive BladderUrinary Incontinence1 more

This study will look at a drug for OAB (solifenacin) in combination with a non drug treatment (bladder training) compared to the drug on its own. The study will compare the symptoms of OAB by assessing patient diaries and other patient reported outcomes.

Completed6 enrollment criteria

Study of VESIcare® In Overactive Bladder (OAB) Subjects to Evaluate Symptom Bother and Health Related...

Urinary BladderOveractive

Evaluate the effect of VESIcare® on symptom bother for subjects with OAB

Completed11 enrollment criteria

Long-term Safety and Efficacy of Imidafenacin in Patients With Overactive Bladder

Overactive Bladder

The purpose of this study is to evaluate the long-term safety and efficacy of imidafenacin.

Completed6 enrollment criteria

Detrol LA In Men With Overactive Bladder.

Overactive Bladder (OAB)

An interventional active/placebo double blinded parallel randomized controlled study in which at 12 weeks of treatment, the primary endpoint of patient perception of bladder condition is measured along with associated safety and other secondary endpoints like bladder diary endpoints, quality of life and patient treatment satisfaction. Patients included in the study must have symptoms of OAB (frequency of at least 8 per day and Urgency of at least 1 episode per day confirmed by bladder diary). Patients are not eligible to enroll in the study if they have/had significant hepatic or renal disease, history of radiation treatment.

Completed2 enrollment criteria

Programmable Timer in the Bladder Rehabilitation Treatment of OAB

Overactive BladderUrinary Incontinence

The purpose of this study is to evaluate the effect of bladder rehabilitation in a non-selected group of children with idiopathic overactive bladder and to clarify whether the effect of the treatment can be increased by addition of a programmable timer

Completed5 enrollment criteria

Controlled Study of ONO-8025 (KRP-197) in Patients With Overactive Bladder in Japan

Overactive Bladder

The purpose of this study is to evaluate the efficacy and safety of ONO-8025 (KRP-197) in patients with overactive bladder.

Completed10 enrollment criteria
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