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Active clinical trials for "Urinary Calculi"

Results 41-50 of 132

Feasibility Study of an Enhanced Lithotripsy System in the Treatment of Urinary Stone Disease

Urinary Stone

This is a single arm, single center study to assess the safety and efficacy of a form of extracorporeal lithotripsy, called the Enhanced Lithotripsy System, to treat urinary stones.

Terminated19 enrollment criteria

Efficacy of Flomax to Improve Stone Passage Following Shock Wave Lithotripsy

Urolithiasis

The majority of kidney stones are treated with shock wave lithotripsy (SWL). We are examining if the medication Flomax will result in improved stone passage rates following SWL.

Terminated5 enrollment criteria

Evaluating the Vitamin K2 Status of Calcium-based Stone Formers

Kidney CalculiCalcium Oxalate Kidney Stones6 more

This is an observation, single site-study with one study visit during which all data and samples will be collected. Study participants will be asked to provide blood, urine, and fecal samples so that the investigators may study the differences in the gut microbiota, vitamin K2 levels, and other parameters between participants who form kidney stones and those who do not.

Active13 enrollment criteria

Evaluation of Kidney Function by Multi-modal Magnetic Resonance Imaging and Spectroscopy

Kidney TransplantationUrinary Calculi

Multimodal functional magnetic resonance (MR) methods, including MR diffusion, Blood-Oxygenation Level Dependent (BOLD) imaging and MR spectroscopy may provide complementary information about the functional status of a kidney. The researchers hypothesize that these non-invasive methods correlate with histology as "gold standard" and compete favorably with conventional in part invasive evaluation methods, and thus provide specific and early detection of kidney diseases of various etiologies, drug toxicity, or renal allograft dysfunction.

Active8 enrollment criteria

Use of a Ureteral Access Sheath During Ureteroscopy and Its Effect on Stone Free Rate

Urinary Calculi

Patients with upper ureteral or renal stones will be randomized to undergoing ureteroscopy with or without a ureteral access sheath. The sheath is designed to facilitate ureteroscope insertion and re-insertion, thus allowing fragments to be basketed out. Stone free rates at 3 months will be determined between the two groups. The investigators hypothesize that the use of the ureteral access sheath with ureteroscopy will result in improved stone free rates at 3 months compared to ureteroscopy without use of a sheath.

Terminated14 enrollment criteria

Pilot Study to Evaluate the Contribution of Gene Variants to Idiopathic Urolithiasis

Kidney StonesUrolithiasis1 more

Recent investigations from this group have identified that genetic variants of genes associated with monogenic forms of nephrolithiasis are expressed in idiopathic calcium oxalate kidney stone patients and could influence stone forming risk. Utilizing patient samples from the Mayo Clinic Florida Kidney Stone Registry, we will demonstrate that expression of these heterozygous mutations in idiopathic nephrolithiasis act as genetic modifiers of disease presentation increasing risk of kidney stone formation. Complimented by the analysis of environmental and lifestyle risk factors, these studies will define environmental and genetic susceptibility factors involved in kidney stone formation and reoccurrence.

Enrolling by invitation10 enrollment criteria

Assessment of Fluoroscopy Times With Surgeon Versus Technologist Control

UrolithiasisKidney Stones

This is a prospective randomized trial to study the effect of assigning the control of the fluoroscopic x-ray activation to the surgeon as compared to the radiation technologist. Radiation exposure will be assessed from the collected data, fluoroscopy time, and dose parameters (cumulative absorbed dose and dose area product). From exposure data, entrance skin dose (ESD) and midline absorbed dose (MLD) will be calculated. The primary outcome in this study will be total fluoroscopy time for the procedure. A secondary outcome will be the ESD. The investigators will further analyze the contribution of clinical predictors (e.g. stone size/location) and procedural predictors on fluoroscopy times and ESD. It is hypothesized that a 30% reduction in fluoroscopy time will occur when the operating surgeon is controlling the activation of the x-ray beam.

Completed4 enrollment criteria

Effect of a High Citrate Beverage on Urine Chemistry in Urinary Stone Disease

Urinary Stone

This study will investigate the effect of a patented high citrate beverage on urine chemistry in patients with urinary stone disease (USD). It is a minimal risk study of an over-the-counter beverage called Moonstone, which is commercially available. This study is considered preparatory for the RO-1 and is not intended to produce a definitive outcome regarding kidney stones.

Completed6 enrollment criteria

Comparison Between Two Shock Wave Regimens for Treating Urinary Stones

Urinary (Renal or Ureteral) Stones

In order to check if a reduction in the frequency and total number of shocks delivered during extracorporeal shockwave lithotripsy (SWL) results in a great number of stone-free patients,the investigators compared two different ways of treating urinary stones using SWL.

Completed7 enrollment criteria

Pharmacokinetic and Safety Study of OMS201 in Subjects Undergoing Ureteroscopic Treatment for Removal...

Urinary CalculiUrinary Stones1 more

Evaluate the safety and systemic absorption of OMS201 following exposure during ureteroscopy.

Completed14 enrollment criteria
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