search

Active clinical trials for "Uterine Neoplasms"

Results 61-70 of 207

Gleevec/Taxol for Patients With Uterine Papillary Serous Carcinoma

Uterine Cancer

Objectives: To determine the maximum tolerated dose (MTD) of imatinib mesylate in combination with fixed dose paclitaxel in patients with stage IIIC, IV or recurrent uterine papillary serous carcinoma. To determine the nature and degree of toxicity of imatinib mesylate and paclitaxel in this cohort of patients. To determine the efficacy of imatinib mesylate and paclitaxel in patients with stage IIIC, IV or recurrent uterine papillary serous carcinoma whose tumor expresses either c-Kit, PDGFR or abl.

Terminated27 enrollment criteria

Patients Who Have Failed First Line Treatment for Locally Advanced and/or Metastatic Cervical Cancer...

Uterine Neoplasms

Primary: To assess the overall response rate of oxaliplatin in patients with bidimensionally measurable disease at baseline. Secondary: To assess the safety and tolerability of oxaliplatin To assess time to progression and overall survival.

Terminated12 enrollment criteria

A Phase II Study of Paclitaxel and Carboplatin in Patients With an Elevated-Risk Cancer of the Uterus...

Uterine Cancer

The main purpose of this study us to determine the best treatment for patients with endometrial cancer who are at an elevated risk for recurrence.

Terminated16 enrollment criteria

A Study on the Safety of GEN1044 (DuoBody®-CD3x5T4) in Patients With Malignant Solid Tumors

Locally Advanced or Metastatic Solid Tumor(s)Prostate Cancer6 more

The purpose of the trial is to evaluate the safety, determine the recommended Phase 2 dose (RP2D), and assess preliminary clinical activity of GEN1044 in patients with solid tumors.

Terminated26 enrollment criteria

Letrozole Versus Observation in Patients With Newly Diagnosed Uterine Leiomyosarcoma

LeiomyosarcomaUterine Neoplasm

The goal of this clinical research study is learn if taking Femara (letrozole) after a hysterectomy (surgical removal of the uterus) for uterine leiomyosarcoma will delay or prevent the cancer from coming back.

Terminated23 enrollment criteria

Bevacizumab and Paclitaxel for Neuroendocrine Tumors of the Cervix

Cervical CancerUterine Cancer

Objectives: Primary: To estimate the efficacy of bevacizumab and paclitaxel in patients with recurrent small cell, large cell, and neuroendocrine cervical and uterine cancers, as measured by progression-free survival. Secondary: To estimate the efficacy of bevacizumab and paclitaxel in patients with recurrent small cell, large cell, and neuroendocrine cervical and uterine cancers, as measured by overall survival. To determine the response rates in patients with recurrent small cell, large cell, and neuroendocrine cervical and uterine cancers when treated with bevacizumab and paclitaxel. To characterize the quality of life (QoL) in patients with recurrent small cell, large cell, and neuroendocrine cervical and uterine cancers when treated with bevacizumab and paclitaxel. To determine the nature and degree of toxicity in patients with advanced or recurrent small cell, large cell, or neuroendocrine cervical and uterine cancers when treated with bevacizumab and paclitaxel.

Terminated33 enrollment criteria

Malignant Mixed Mesodermal Tumor (MMMT) - Early Stage With Postoperative XRT/Chemotherapy

Uterine Neoplasms

Primary Objectives: To test whether the addition of chemotherapy to radiotherapy improves the progression-free survival for patients with stage I, II and IIIa malignant mixed mesodermal tumor (MMMT) of the uterus. To determine the acute and late toxicity profiles associated with this treatment regimen. To describe the effect of this treatment regimen on the patient's quality of life.

Terminated16 enrollment criteria

Radiation Therapy, Paclitaxel, and Carboplatin in Treating Patients With Uterine Cancer

Stage IA Uterine SarcomaStage IB Uterine Sarcoma9 more

This pilot clinical trial studies radiation therapy, paclitaxel, and carboplatin in treating patients with uterine cancer. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or stopping them from dividing. Giving radiation with chemotherapy may kill more tumor cells.

Terminated16 enrollment criteria

Tissue Acquisition and Genomics Analysis of Breast Cancer and Other Gynecologic Malignancies

Breast CancerOvarian Cancer1 more

Background: A person s blood, tissue, and other samples contain DNA. Cancer is a disease of cells that are not working properly. It is caused by changes in DNA that build up. Researchers want to do future studies on DNA changes This may help them learn how to guide treatment for cancer. They need biological samples like tumors, blood, and urine for these studies. Objective: To create a place to collect and store biological samples from people with gynecologic malignancies like breast cancer. Samples from certain relatives of theirs will be collected too. Eligibility: Adults ages 18 and older who are being seen at NIH for breast cancer or other gynecologic malignancy Their biological relatives of the same age Design: Participants will answer questions about their family history. Participants will have a physical exam and medical history. This will include questions about age, ethnicity, and disease history. They will also answer questions about their medical treatments and responses. Participants will give blood and urine samples. Participants may give a tumor tissue sample. This will not be taken specifically for this study. It will be from a previous procedure or one that is already planned. Other samples may be taken only if a procedure is required for treatment. These include bone marrow, cerebrospinal fluid, and other fluids. A group of doctors and other professionals will oversee the sample storage place. The group will review all requests to be sure the use of the specimens is valid.

Enrolling by invitation9 enrollment criteria

Feasibility Trial of Intraperitoneal Chemotherapy for Ovarian, Fallopian Tube, and Primary Peritoneal...

Ovarian CancerFallopian Tube Cancer2 more

The purpose of this study is to evaluate giving chemotherapy drugs directly into the abdomen (belly) along with intravenous administration.

Terminated6 enrollment criteria
1...678...21

Need Help? Contact our team!


We'll reach out to this number within 24 hrs