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Active clinical trials for "Dementia, Vascular"

Results 51-60 of 138

Efficacy and Safety of Donepezil Hydrochloride (Aricept) in Vascular Dementia

Vascular Dementia

The purpose of this study is to examine the efficacy and safety of cholinesterase inhibitor (donepezil hydrochloride) Aricept in patients with vascular dementia (VaD).

Completed5 enrollment criteria

Rivastigmine Capsules in Patients With Probable Vascular Dementia

Vascular Dementia

The goal of this research study is to evaluate, in the open-label extension phase, the effectiveness, tolerability and safety of rivastigmine capsules in males and females between the ages of 50 and 85 years old with probable vascular dementia.

Completed2 enrollment criteria

Efficacy and Safety of TMBCZG in Mild to Moderate Vascular Dementia

Vascular Dementia

The study will be a 24-week multicentre, double-blind, placebo-controlled phase Ⅱa trial with 4 treatment arms in China. Participants aged 55-80 years will be randomized to TMBCZG-high dose(84mg per day), TMBCZG- medium dose(56mg per day), TMBCZG- low dose(28mg per day) or to placebo. The primary endpoint will be VADAS-Cog and CDR-SB. Secondary outcomes included changes in MMSE and ADL. Patients' safety will be assessed by recording of adverse events, clinical examinations, electrocardiography and laboratory tests. The patients, caregivers, and investigators will be blinded to the treatment allocations.

Completed26 enrollment criteria

Study of STA-1 Capsule in Patients With Vascular Dementia (Marrow-Sea Deficiency)

Vascular Dementia

The objectives of this phase II study of STA-1 capsule was to make preliminary evaluation on clinical efficacy and safety of STA-1 capsule in order that based on the dosage and study structure planned in this project, the dosage and study structure of phase III study can be confirmed.

Completed29 enrollment criteria

Optimizing Dementia Care

Alzheimer's DiseaseDementia4 more

The purpose of this randomized controlled pilot study is to examine the preliminary effectiveness, feasibility, and potential treatment moderators (i.e., behavioral symptoms and spousal relationship status) of a newly developed intervention for individuals with dementia and their family caregivers that combines elements of the established care consultation (CC) approach with additional counseling modules (CC+C). Outcomes for Veterans with dementia and their family caregivers (e.g., depressive symptoms, care-related burden, quality of life, pleasant events, etc.) will be assessed after 6 months of treatment and again at 12 months.

Completed20 enrollment criteria

Reshaping the Path of Vascular Cognitive Impairment (VCI)

Transient Ischemic AttackVascular Cognitive Impairment1 more

The investigators will conduct a proof-of-concept randomized controlled trial study to provide preliminary evidence of efficacy of a resistance exercise training program for maintaining white matter health and improving cognitive function in older adults with vascular cognitive impairment, defined as the presence of cognitive impairment combined with cerebral small vessel disease, compared with a stretch and relaxation program.

Completed21 enrollment criteria

Low-Dose Opiate Therapy for Discomfort in Dementia (L-DOT)

Alzheimer DiseaseDementia3 more

The purpose of this study was to determine whether a low dose an opiate pain medication is effective for the treatment of discomfort in patients with advanced dementia. The study medication was also known as Lortab and contained both a narcotic pain medication and acetaminophen (the same pain medication as contained in Tylenol). This study was an eight-week long clinical trial for discomfort among veterans with advanced dementia who were admitted to a Nursing Home Care Unit (NHCU) at the Tuscaloosa VA Medical Center.

Completed16 enrollment criteria

A Study of the Safety and Effectiveness of Galantamine Versus Placebo in the Treatment of Patients...

Alzheimer DiseaseVascular Dementia

The purpose of this study is to evaluate the safety and efficacy of galantamine (a drug for treating dementia) compared to placebo in the treatment of patients with dementia related to cerebrovascular disease (vascular dementia) or dementia related to Alzheimer's disease with cerebrovascular disease ("mixed" dementia).

Completed10 enrollment criteria

Donepezil Hydrochloride (E2020) in Dementia Associated With Cerebrovascular Disease

DementiaVascular

Twenty-four week, prospective, randomized, double-blind, placebo-controlled, parallel-group study.

Completed10 enrollment criteria

DAOIB for the Treatment of Cognitive Function and Behavioral and Psychological Symptoms of Dementia...

Behavioral and Psychological Symptoms in Alzheimer's DiseaseBehavioral and Psychological Symptoms in Vascular Dementia

The population of dementia is increasing rapidly. Cognitive impairment as well as Behavioral and psychological symptoms of dementia (BPSD) add heavy burdens to caregiver. NMDA activation is critical for learning and memory. Individuals with Alzheimer's disease (AD) have fewer NMDA receptors in the frontal cortex and hippocampus than controls. This study is a randomized, double-blind, placebo-controlled drug trial. All patients will be allocated randomly to two groups: (1) NMDA enhancer: DAOIB (starting dosage: 250-500 mg/day), (2) placebo, for 6 weeks. The investigators hypothesize that DAOIB may yield better efficacy than placebo for cognitive function and clinical symptoms in patients with BPSD.

Completed8 enrollment criteria
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