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Active clinical trials for "Hypotension"

Results 271-280 of 875

Transcutaneous Electrical Acupoint Stimulation(TEAS) for Hypotension After Spinal Anesthesia in...

Hypotension

The purpose of this study is to compare the effect of TEAS on hypotension after spinal anesthesia in patients undergoing cesarean section

Completed9 enrollment criteria

An Open-label Trial of Clevidipine for Controlled Hypotension During Spinal Fusion

Neuromuscular Scoliosis

The current study would prospectively evaluate the dosing requirements, efficacy and safety of clevidipine for controlled hypotension during spinal surgery in the pediatric population. As the investigators currently have projects underway which include those patients having scoliosis surgery for idiopathic scoliosis, this trial would include only those undergoing scoliosis surgery for neuromuscular disease.

Completed5 enrollment criteria

Best Regimen for Phenylephrine Administration During Cesarean Section

Cesarean SectionCardiac Output1 more

During Cesarean delivery, phenylephrine is used to maintain the patient's blood pressure. Low blood pressure is the most common side effect of the spinal medication used to anesthetize the patient prior to the start of surgery. This low blood pressure can also trigger unpleasant side effects such as nausea, vomiting and low Apgar scores for the baby. Currently there are 2 methods of phenylephrine administration during Cesarean section. One method is by intermittent bolus and the other is by continuous infusion. It is ideal to have a regimen for phenylephrine administration that maintains blood pressure without compromising cardiac output. In this study, cardiac output and blood pressure will be measured by transthoracic bioimpedance, which is a new technique of noninvasive continuous cardiac output monitoring. The hypothesis of this study is that the continuous infusion of phenylephrine will be equally effective in maintaining blood pressure as compared to the intermittent injection, and will induce less hemodynamic changes.

Completed14 enrollment criteria

Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH)

Symptomatic Neurogenic Orthostatic Hypotension (NOH)Non-diabetic Neuropathy2 more

The purpose of this study is to see whether droxidopa is effective in treating symptoms of neurogenic orthostatic hypotension in patients with Primary Autonomic Failure (Pure Autonomic Failure, Multiple System Atrophy, Parkinson's Disease), Non-diabetic neuropathy, or Beta Hydroxylase deficiency.

Completed19 enrollment criteria

Spinal Anesthesia Induced Hypotension During Cesarean Section

Hypotension

The purpose of this study is to compare two methods for preventing low blood pressure associated with spinal anesthesia during Cesarean sections.

Completed17 enrollment criteria

Study to Assess the Benefit of Midodrine in the Treatment of Patients With Neurogenic Orthostatic...

HypotensionOrthostatic

The purpose of this clinical study is to evaluate the clinical effect of midodrine hydrochloride (ProAmatine®) compared to placebo in patients with orthostatic hypotension by measuring the time to onset of near syncopal symptoms and assessing several cardiovascular measurements, such as heart rate, blood pressure, and ECG, using the tilt table test.

Completed12 enrollment criteria

Phase III Study of Hemospan® for Treating Hypotension in Hip Arthroplasty

HypotensionIschemia

The purpose of this study is to determine whether Hemospan is superior to Voluven for treatment of hypotensive episodes during the perioperative period (from induction of spinal anesthesia until 6 hours after skin closure), and for reducing the incidence of operative and postoperative complications including organ dysfunction and failure until follow-up at one month following surgery. An independent Data Safety Monitoring Board (DSMB) will periodically evaluate the safety data collected during this trial

Completed15 enrollment criteria

Phase III Study of Hemospan® to Prevent Hypotension in Hip Arthroplasty

HypotensionIschemia

The purpose of this study is to determine whether Hemospan is superior to Voluven for preventing hypotensive episodes during the perioperative period (from induction of spinal anesthesia until 6 hours after skin closure), and for reducing the incidence of operative and postoperative complications including organ dysfunction and failure until follow-up at one month following surgery. An independent Data Safety Monitoring Board (DSMB) will periodically evaluate the safety data collected during this trial.

Completed15 enrollment criteria

Extended Therapy of Drotrecogin Alfa (Activated) 4 vs 7 Days Infusion

SepsisHypotension

The purpose of this study is to determine whether continued administration of Drotrecogin Alfa (Activated) up to additional 72 hours - after the so far recommended 96 hour infusion period - results in a more rapid resolution of hypotension in severe septic patients.

Completed7 enrollment criteria

Dose-Response Study of Sodium Nitroprusside in Children Requiring Controlled Hypotension in the...

Hypotension

Sodium nitroprusside (SNP) has been approved for control of blood pressure in adults, yet there are no controlled studies in children. The purpose of this study is to determine the efficacy and safety of sodium nitroprusside in children who will be having surgery, and who require blood pressure lowering in order to decrease the amount of blood loss during their surgery.

Completed16 enrollment criteria
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