search

Active clinical trials for "Virus Diseases"

Results 41-50 of 838

Quality of Life After Primary TORS vs IMRT for Patients With Early-stage Oropharyngeal Squamous...

Oropharynx CancerOropharynx Squamous Cell Carcinoma20 more

Oropharyngeal squamous cell carcinoma (OPSCC) is now the most frequently diagnosed head and neck cancer in Denmark which is mainly due to the increase of Human Papillomavirus (HPV). Patients with HPV-positive OPSCC have a significantly higher survival rate compared to HPV-negative OPSCC. The traditional primary treatment modality in Denmark is Intensity Modulated Radiation Therapy (IMRT), and in advanced stages in combination with chemotherapy. Since 2009, Transoral Robotic Surgery (TORS) has enabled surgeons to perform minimally invasive surgery as an alternative to standard radiotherapy treatment which is considered the primary treatment for OPSCC in many countries. There is a lack of randomised trials comparing long-term functional outcomes after TORS or IMRT. Current data are mostly derived from retrospective studies with selection bias. However, several small retrospective studies have shown promising results when comparing the two treatment modalities in favour of TORS with regards to treatment related swallowing function and quality of life (QoL) without compromising survival outcomes. This study aims to evaluate the early and long-term functional outcomes following two treatment arms 1) TORS combined with neck dissection and 2) IMRT±concurrent chemotherapy with a special focus on swallowing-related QoL.

Recruiting18 enrollment criteria

Clinical Trial for Oral Formula of Vanillin and Wheat Germ Oil for Treatment of Mild and Moderate...

Mild-to-moderate COVID-19

The study is a randomized clinical trial to assess a natural formula of vanillin & wheat germ oil to treat and stop the clinical progression of COVID-19. The study aims to treat people with mild-to-moderate COVID-19 before their cases become severe. The study duration is a 5-day experimental intervention and an extended 4 weeks follow up.

Recruiting9 enrollment criteria

A Study to Evaluate the Safety and Immune Response of mRNA-1345, a Vaccine Targeting Respiratory...

Respiratory Syncytial Virus

The main purpose of this study is to evaluate the safety and immunogenicity of mRNA-1345 RSV vaccine when coadministered with a high dose (HD) quadrivalent seasonal influenza vaccine (Fluzone HD) in adults ≥65 years of age. The study will examine the impact of Fluzone HD on the immune response to mRNA-1345 against RSV-A and RSV-B, as well as the impact of mRNA-1345 on the immune response to Fluzone HD against 4 vaccine-matched Influenza A and B strains.

Recruiting14 enrollment criteria

Development of a Self-collection Device for Cervical Cancer Screening

Human Papilloma Virus Infection Type 16Human Papilloma Virus Infection Type 181 more

Evaluation of a novel self-collection device for cervical cancer screening.

Recruiting14 enrollment criteria

Safety and Immunogenicity of an Intranasal Vaccine for Respiratory Syncytial Virus in Seronegative...

Respiratory Syncytial Virus (RSV)

This study evaluates an investigational vaccine that is designed to protect humans against infection with respiratory syncytial virus (RSV) and is administered as a nasal spray. Specifically, the study analyzes the safety of, and the immune response to, the vaccine when administered to healthy children between the ages of 6 and 24 months who are seronegative to RSV.

Recruiting13 enrollment criteria

Assessement of Viral Shedding Duration After a Respiratory Tract Infection in Oncology and Hematology...

Respiratory Tract Viral Infection

The purpose of this study is to assess the duration of the viral shedding in hematology and oncology patients after a respiratory tract viral infection. This duration has not been much studied in that population whereas it is probably longer than that in immunocompetent patients. Thereby it may be a source of transmission amongst these immunocompromised patients.

Recruiting7 enrollment criteria

Study to Evaluate Immunogenicity, Safety and Tolerability of Adjuvanted and Non-Adjuvanted H2N3...

InfluenzaHuman4 more

This Phase 1, randomized, observer-blind, dose-ranging clinical study is evaluating 6 different formulations of MF59-adjuvanted and non-adjuvanted H2N3 influenza vaccine. Approximately 600 healthy adult subjects are to be randomized into 1 of 6 possible treatment groups with 100 subjects per group, stratified by age group (born after or before 1968). Each subject will receive an influenza vaccine injection on Day 1 and Day 22. Subjects will be followed up for approximately 12 months after the second vaccine injection. The primary immunogenicity analysis is based on the Day 1, Day 8, Day 22, Day 29, and Day 43 serology data. The primary safety analysis is based on solicited local and systemic adverse events (AEs) reported within 10 days after each vaccination, unsolicited AEs reported within 3 weeks after each vaccination, and serious AEs (SAEs), medically attended AEs (MAAEs), AEs leading to withdrawal from the study, and AEs of special interest (AESIs) reported throughout the study.

Recruiting21 enrollment criteria

Study of Posoleucel (ALVR105,Viralym-M) for Multi-Virus Prevention in Patients Post-Allogeneic Hematopoietic...

Adenovirus InfectionBK Virus Infection4 more

This is a Phase 3 study to evaluate posoleucel (ALVR105, Viralym-M); an allogeneic, off-the-shelf multi-virus specific T cell therapy that targets six viral pathogens: BK virus, cytomegalovirus, adenovirus, Epstein-Barr virus, human herpesvirus 6 and JC virus.

Recruiting19 enrollment criteria

Post Transplant Cyclophosphamide in Matched Unrelated Donor Stem Cell Transplantation for Hematological...

Bone Marrow Transplant ComplicationsGraft Versus Host Disease3 more

This study aims to evaluate the clinical efficacy of cyclophosphamide in patients receiving a bone marrow graft from a matched unrelated donor in overall survival, progression free survival and cumulative incidence of acute and chronic GvHD. Thirty patients will receive cyclophosphamide while twenty patients will receive antihuman T-lymphocyte immune globulin (ATG).

Recruiting11 enrollment criteria

Safety and Immunogenicity of a Single Dose of the Recombinant Live-Attenuated Respiratory Syncytial...

Respiratory Syncytial Virus (RSV)

The purpose of this study is to evaluate the safety and immunogenicity of a single dose of the recombinant live-attenuated respiratory syncytial virus (RSV) vaccines, RSV ΔNS2/Δ1313/I1314L, RSV 6120/ΔNS2/1030s, and RSV 276, in RSV-seronegative children 6 to 24 months of age.

Recruiting51 enrollment criteria
1...456...84

Need Help? Contact our team!


We'll reach out to this number within 24 hrs