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Active clinical trials for "Weight Loss"

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PATH to Health: An Exploration of Digital Behavioral Weight Loss Approaches

OverweightObesity1 more

The purpose of this initial pilot and feasibility study is to test different digital, behavioral weight loss approaches, with or without human support, using a sequential, multiple assignment, randomized trial (SMART) design. All participants in this pilot trial will receive a 3-month mobile health (mHealth) program. The dose of human support will vary by first- and second-line randomizations. The feasibility, acceptability, and preliminary outcomes for each of the treatment sequences will be assessed.

Recruiting19 enrollment criteria

The Banded Mini Gastric Bypass Trial: A Prospective Randomized Controlled Trial

Bariatric SurgeryWeight Loss1 more

Rationale: Investigate if there is a significant weight reduction expressed in total body weight loss percentage (%TBWL) in patients 5 years after surgery, whom underwent a mini gastric bypass (MGB-OAGB) with addition of the implantation of a MiniMizer Ring. Study design: A prospective non blinded single centre randomized controlled trial. Sudy population: The study population will exist of patients eligible for MGB-OAGB surgery. Patients are invited to participate if Body Mass Index (BMI) ≥ 35kg/m2 with a comorbidity related to morbid obesity, or a BMI exceeding 40kg/m2. Intervention: Insertion of the MiniMizer Ring around the gastric pouch in addition to the 'standard' MGB-OAGB. Main study parameters/endpoints: Primary Objective: %TBWL 5 years after surgery. Secondary Objectives: Percentage Excess Weight Loss (%EWL) 5 years after surgery. Decrease or reduction of comorbidities (diabetes mellitus, hypertension, hyperlipidemia, sleep apnoea, and joint complaints). Improvement of quality of life: SF-36 and OBESI-Q questionnaires. Incidence and severity of dumping syndrome. Incidence and severity of reflux symptoms: GERD-HRQoL questionnaire. Incidence and complications due to silicone band. Measurement of objectives are before surgery and six times after surgery combined with the standard postoperative care for patients who undergo bariatric surgery: Expected advantages of bOLGB versus OLGB: Increase of weight reduction, and due to that decrease of comorbidities and/or mortality related to overweight. Long term decrease of weight regain. Decrease of incidence of dumping. Possible disadvantages of bOLGB versus OLGB: Band-related complications such as erosion, infection, stenosis, or pouch dilatation. Functional gastro-intestinal complains such as dysphagia and reflux.

Recruiting10 enrollment criteria

Enhanced DPP-GLB to Promote Weight Loss Among Nonresponders in a Community-Based Lifestyle Intervention....

Diabetes

This study seeks to establish the efficacy of identifying weight loss nonresponders early in a Diabetes Prevention Program (DPP) intervention in 20 community settings (primarily churches and community centers) and providing them with individual-level, enhanced treatment through telephone contacts and access to additional resources. Additionally, potential mediators and moderators of the relationship between intervention status and weight loss response at 6 months in both nonresponders and responders will be examined and a cost-effectiveness analysis to evaluate the cost of the intervention will be conducted. This study addresses key gaps in the literature about the weight loss effects of identifying nonresponders early and characterizing individuals who need more intense personalized strategies. The investigators hypothesize that changes between baseline and 3 months will be more pronounced among the nonresponders in the intervention group compared to the nonresponders in the active control group.

Recruiting10 enrollment criteria

Time-restricted Eating Versus Daily Continuous Calorie Restriction on Body Weight and Colorectal...

Time Restricted EatingObesity2 more

Approximately 42% of American adults are obese, and this condition is strongly related to the development of colorectal cancer. Innovative lifestyle strategies to treat obesity and reduce colorectal cancer risk are critically needed. This research will demonstrate that time-restricted eating, a type of intermittent fasting, is an effective therapy to help obese individuals reduce and control their body weight and prevent the development of colorectal cancer.

Recruiting21 enrollment criteria

Weight Loss Effects of M-health App in Obesity Multidisciplinary Outpatient Clinic

Obesitym-Health1 more

This is a randomized, open, controlled, single-center trial to identify the weight loss effects of adding mobile health application in obesity multidisciplinary outpatient clinic.

Enrolling by invitation11 enrollment criteria

Prospective Study on the Consequences of Weight Loss After Bariatric Surgery on Obese Patients'...

Low Back Pain in Obese Patients After Important Weight Loss

The purpose of this study is to determine how an important weight loss after bariatric surgery affects obese patients ' spine, and the effects it has on low back pain, sagittal alignment and lipomatosis .

Recruiting12 enrollment criteria

Eating Mindfully to Prevent Weight Regain

Weight LossWeight Gain3 more

The overall objective of this study is to evaluate the efficacy of a mindfulness-based intervention to prevent weight regain in weight-reduced adults.

Recruiting6 enrollment criteria

Akkermansia and Weight Maintenance

ObesityMicrotia2 more

Obesity and related disorders such as type 2 diabetes are a worldwide diet-related problem. As such new treatment options are constantly being developed. Bacteria living in the gut seem to be a key player in the treatment of obesity and related metabolic diseases by influencing energy balance and the immune system. In terms of newly identified bacteria species, Akkermansia muciniphila (A. muciniphila) has been found to be related to obesity. Several animal studies have shown the beneficial impact of A. muciniphila on the treatment of body weight as well as insulin sensitivity. The growth requirements of live A. muciniphila as well as its oxygen sensitivity rendered this bacterium unsuitable for human investigations or putative therapeutic opportunities. Therefore, pasteurization, a mild heating method, and its impact on diet-induced metabolic disorders in mice were investigated. Unexpectedly, this method of inactivation did not negate the effect of A. muciniphila, but improved its beneficial metabolic effects. Pilot studies have provided further evidence that pasteurization of A. muciniphila is safe for human use and has the potential to beneficially affect the control of body weight and glucose metabolism. In this project, The investigators hypothesize that pasteurized A. muciniphila will be superior to placebo intervention in maintaining body weight after a phase of weight loss (low caloric diet) in adult participants with overweight or obesity.

Recruiting17 enrollment criteria

Financial Coaching and Lifestyle Intervention for Diabetes Prevention in Low-income Families

Weight Loss

The purpose of this study is to compare the effect on weight and metabolic outcomes of an enhanced intervention, comprised of evidence-based financial coaching plus a lifestyle intervention vs. the lifestyle intervention alone

Recruiting9 enrollment criteria

Comparing Olanzapine and Mirtazapine in the Improvement of Unintentional Weight Loss for Patients...

Anorexia Nervosa With Significantly Low Body Weight

To determine whether olanzapine or mirtazapine is more effective in preventing weight loss and appetite loss in cancer patients.

Enrolling by invitation15 enrollment criteria
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