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Active clinical trials for "Heart and Blood Diseases"

Results 52621-52630 of 52710

Could Non-invasive Biochemical, Image or Physiological Index Predict Significant Coronary Arterial...

Coronary Heart Disease

To validate the capability of non-invasive bio-image tests in prediction of significant coronary stenosis of symptomatic adults.

Unknown status2 enrollment criteria

Genetics Study of In-stent Restenosis

Coronary Artery Disease

The investigators hypothesized that genetic variants of G protein influence the development of restenosis and clinical outcome of patients receiving drug-eluting stents (DES).

Unknown status2 enrollment criteria

Identification of Biomarkers Predictive of Worse Prognosis in Henoch Schonlein Purpura

PurpuraSchoenlein-Henoch

Henoch Schonlein Purpura (HSP), vasculitis of small vessels with deposits of IgA, is considered by many authors as the systemic form of Berger's disease (IgA-N). IgA-N is characterized by IgA1 deposits in mesangial areas associated with mesangial proliferation. These two diseases remain the leading cause of ESRD by primitive glomerulopathy in Western countries. In recent years, considerable progress has been made in understanding the pathophysiological mechanisms of IgA-N. However, only a high rate of proteinuria at one year or the presence of severe glomerular inflammation on renal biopsy remain predictors of long term renal function. Moreover, the high variability of HSP clinical expression, from few purpura skin lesions that evolve favourably spontaneously, to rapidly progressive renal failure, remains so far unexplained but suggests the existence of individual genetic susceptibility. In the first part of the study, we will study key factors based on physiopathological data obtained by our laboratory as well as by other groups. The second part of the study concerns genetic factors. Although the candidate genes that may confer a particular susceptibility to the disease, to progress to ESRD or respond to treatment are many, the genes involved in inflammation or controlling renin-angiotensin system are of particular interest. We will apply these results by studying patients with HSP showing three distinct phenotypes (HSP with isolated cutaneous purpura or associated with minimal or severe renal disease) at diagnosis and after clinical remission. The purpose of this study is to assess whether the phenotype at diagnosis is associated with the physiological markers and if one of them predicts a pejorative evolution of renal disease at 1 year. Meanwhile, study of polymorphism of selected genes of interest could allow identification of patients with specific genetic susceptibility or with bad prognosis factors who would be thus eligible for specific treatment.

Unknown status3 enrollment criteria

Healing Response to Everolimus-eluting Stent Implantation; Serial Assessment With opticaL Coherence...

Coronary Heart Disease

The purpose of this study is to evaluate serial changes of neointimal coverage after everolimus-eluting stent implantation at 3-, 6- and 12-months by OCT examination.

Unknown status15 enrollment criteria

Cerebrovascular Autoregulation During and After Liver Transplantation

EncephalopathyHepatic2 more

The cerebrovascular autoregulation (AR) is impaired in patients with hepatic encephalopathy. Patients with the indication to liver transplantation mostly have mild to severe hepatic encephalopathy. Transplantation should recover the encephalopathy. The aim of the study is to investigate the AR during liver transplantation, with the questions if the AR is impaired at the beginning of surgery and if there are changes in AR. For follow up the AR will be measured at the first days after transplantation at the ICU.

Unknown status6 enrollment criteria

Atherosclerosis in Atrial Fibrillation

Atrial FibrillationMetabolic Syndrome4 more

The prevalence of metabolic syndrome in patients suffering from non valvular atrial fibrillation is derived from studies regarding recurrences of atrial fibrillation after catheter ablation. Prospective studies in european countries are lacking. Furthermore, the impact of metabolic syndrome on cardiovascular events in patients with non valvular atrial fibrillation is still unknown.

Unknown status4 enrollment criteria

A French Multi-centric Atrial Fibrillation Catheter Ablation Survey

Observation of Outcome After Catheter Ablation of Atrial Fibrillation

Atrial fibrillation is the most frequent sustained arrhythmia. Catheter ablation is a procedure that is currently used for the treatment of symptomatic atrial fibrillation patients. We have organized a multi-centric national survey of catheter ablation of atrial fibrillation in order to have a feedback on the type of procedures being performed and the overall results (freedom of atrial fibrillation) over an average follow-up of 18 months.

Unknown status2 enrollment criteria

Heart Rate and Initial Presentation of Cardiovascular Diseases (Caliber)

Abdominal Aortic AneurysmCoronary Heart Disease NOS13 more

Study of heterogeneity in associations between heart rate and the initial presentation of 12 cardiovascular diseases.

Unknown status4 enrollment criteria

Screening Cardiovascular Patients for Aortic aNeurysms (SCAN)

Abdominal Aortic AneurysmAAA

The aim of the cohort study SCAN (Screening Cardiovascular patients for Aortic aNeurysms) is to establish a screening programm for patients with a high risk for an AAA. Aortic aneurysms in these patients should be identified at an early stage and thereby AAA-associated mortality be decreased.

Unknown status5 enrollment criteria

Venous Thromboembolic Complications in Ovarian Cancer

Venous ThromboembolismOvarian Neoplasms3 more

Objectives of the study are: To estimate the incidence of venous thromboembolism (VTE) in a cohort of women with suspected ovarian cancer and evaluate changes in the coagulation system in case of benign or malignant disease. The impact of changes in the coagulation system on disease prognosis will be evaluated.

Unknown status5 enrollment criteria
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