Neuropsychiatric Evaluation of Healthy Volunteers and Adults With Schizophrenia

INCLUSION CRITERIA English-speaking adults between ages 21 to 65, in good health and free from significant substance abuse. Children between ages 4 to 20 must not have a history of special education, using psychotropic medication in long-term counseling or with a history of seizures, head injury or CNS infections. Normal controls will be recruited and screened for exclusionary morbidity by interview (e.g., no history of contact with mental health professionals, no history of diagnosable alcohol and/or substance abuse). Normal controls will be recruited from building employees, local universities, from NIMH rosters, and the general public. EXCLUSION CRITERIA Excluded are adults with histories of dementing illness, movement disorder, affective disorders, developmental and/or acquired brain injury. Diagnoses will be made by review of medical records, interview, examination, and in the case of psychiatric diagnoses, a structured interview by SCID. Advertisement will make clear that the subjects will be asked questions about family psychiatric history and their own history or psychiatric disorder, substance abuse, and neurological disease. Only if the subject answers these negatively will he or she participate in this study.