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Familial Prostate Cancer

Primary Purpose

Neoplastic Syndromes, Hereditary, Prostatic Neoplasms

Status
Completed
Phase
Locations
United States
Study Type
Observational
Intervention
Sponsored by
National Cancer Institute (NCI)
About
Eligibility
Locations
Outcomes
Full info

About this trial

This is an observational trial for Neoplastic Syndromes, Hereditary focused on measuring Familial, Inherited Prostate Cancer, Linkage, Prostate Cancer

Eligibility Criteria

undefined - undefined (Child, Adult, Older Adult)All SexesDoes not accept healthy volunteers

Families will be identified with two or more first degree relatives affected with prostate cancer or with one male with prostate cancer that developed before age 55. Must have clinical evidence of prostate cancer in the family.

Sites / Locations

  • National Cancer Institute (NCI)

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

First Posted
November 3, 1999
Last Updated
March 3, 2008
Sponsor
National Cancer Institute (NCI)
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1. Study Identification

Unique Protocol Identification Number
NCT00001377
Brief Title
Familial Prostate Cancer
Official Title
Familial Prostate Cancer
Study Type
Observational

2. Study Status

Record Verification Date
December 1999
Overall Recruitment Status
Completed
Study Start Date
December 1993 (undefined)
Primary Completion Date
undefined (undefined)
Study Completion Date
December 2000 (undefined)

3. Sponsor/Collaborators

Name of the Sponsor
National Cancer Institute (NCI)

4. Oversight

5. Study Description

Brief Summary
The purpose of this study is to identify affected individuals in families with prostate cancer and to use this information to identify genetic markers closely-linked to the disease gene.
Detailed Description
The purpose of this study is to identify affected individuals in families with prostate cancer and to use this information to identify genetic markers closely-linked to the disease gene.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Neoplastic Syndromes, Hereditary, Prostatic Neoplasms
Keywords
Familial, Inherited Prostate Cancer, Linkage, Prostate Cancer

7. Study Design

Enrollment
200 (false)

10. Eligibility

Sex
All
Accepts Healthy Volunteers
No
Eligibility Criteria
Families will be identified with two or more first degree relatives affected with prostate cancer or with one male with prostate cancer that developed before age 55. Must have clinical evidence of prostate cancer in the family.
Facility Information:
Facility Name
National Cancer Institute (NCI)
City
Bethesda
State/Province
Maryland
ZIP/Postal Code
20892
Country
United States

12. IPD Sharing Statement

Citations:
PubMed Identifier
8625320
Citation
Vocke CD, Pozzatti RO, Bostwick DG, Florence CD, Jennings SB, Strup SE, Duray PH, Liotta LA, Emmert-Buck MR, Linehan WM. Analysis of 99 microdissected prostate carcinomas reveals a high frequency of allelic loss on chromosome 8p12-21. Cancer Res. 1996 May 15;56(10):2411-6.
Results Reference
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PubMed Identifier
9041206
Citation
Bright RK, Vocke CD, Emmert-Buck MR, Duray PH, Solomon D, Fetsch P, Rhim JS, Linehan WM, Topalian SL. Generation and genetic characterization of immortal human prostate epithelial cell lines derived from primary cancer specimens. Cancer Res. 1997 Mar 1;57(5):995-1002.
Results Reference
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PubMed Identifier
7606709
Citation
Emmert-Buck MR, Vocke CD, Pozzatti RO, Duray PH, Jennings SB, Florence CD, Zhuang Z, Bostwick DG, Liotta LA, Linehan WM. Allelic loss on chromosome 8p12-21 in microdissected prostatic intraepithelial neoplasia. Cancer Res. 1995 Jul 15;55(14):2959-62.
Results Reference
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Familial Prostate Cancer

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