Anger and Cardiovascular Risk in Urban Youth
Primary Purpose
Cardiovascular Diseases, Heart Diseases, Hypertension
Status
Completed
Phase
Locations
Study Type
Observational
Intervention
Sponsored by

About this trial
This is an observational trial for Cardiovascular Diseases
Eligibility Criteria
Sites / Locations
Outcomes
Primary Outcome Measures
Secondary Outcome Measures
Full Information
NCT ID
NCT00005383
First Posted
May 25, 2000
Last Updated
February 17, 2016
Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
1. Study Identification
Unique Protocol Identification Number
NCT00005383
Brief Title
Anger and Cardiovascular Risk in Urban Youth
Study Type
Observational
2. Study Status
Record Verification Date
September 2002
Overall Recruitment Status
Completed
Study Start Date
January 1995 (undefined)
Primary Completion Date
undefined (undefined)
Study Completion Date
December 1999 (Actual)
3. Sponsor/Collaborators
Name of the Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
4. Oversight
5. Study Description
Brief Summary
To examine anger and cardiovascular disease risk in urban youth. The project studied patterns of hemodynamic responses to social and nonsocial stressors, ambulatory blood pressure (BP), fasting insulin, fasting glucose, lipid profiles, and central obesity in adolescents from a wide range of socioeconomic status (SES) backgrounds.
Detailed Description
BACKGROUND:
Urban adolescents at high risk for cardiovascular disease (CVD) exhibit a pattern of hemodynamic responses that: (a) is evoked by social encounters that arouse anger, defensiveness, and distrust; (b) appears related to increased insulin resistance; (c) is more pronounced in males and African Americans; and (d) may constitute a pathway via which chronic exposure to stressful social environments increases CVD risk.
DESIGN NARRATIVE:
There were four studies. Study 1 in the first two years measured hemodynamics in 200 subjects to test the hypothesis that hostile distrust was associated with increased total peripheral resistance (TPR) response to social challenge, and that adolescents exhibiting this response pattern had elevated levels of ambulatory BP, fasting insulin, glucose, blood lipids, and central obesity. Study 2 followed 200 subjects for four years to determine if defensive hostility and distrust were related to tracking at higher levels of BP (measured every 6 months), and insulin/ glucose/ cholesterol (measured once per year). Study 3 in years 3 and 4 evaluated the influence of race on the cross-situational consistency of hostile distrust/BP by measuring the latter responses in 200 adolescents during structured encounters with a friend of the same race and sex, an unfamiliar same-race peer, and an unfamiliar other-race peer (black or white). Study 4 evaluated video and audiotape recordings from Studies 1 and 3 to test the hypothesis that distrustful individuals expressed more hostile affect in encounters with others, elicited more negative treatment, were perceived as hostile regardless of observer race or gender, and thus experienced chronic, health-damaging interpersonal stress. Study 4 data were used to examine the possibility that hostile distrust is related to exposure to crime, poverty, and racial discrimination.
The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Cardiovascular Diseases, Heart Diseases, Hypertension, Obesity
7. Study Design
10. Eligibility
Sex
Male
Maximum Age & Unit of Time
100 Years
Accepts Healthy Volunteers
No
12. IPD Sharing Statement
Citations:
PubMed Identifier
9545651
Citation
Ewart CK, Jorgensen RS, Kolodner KB. Sociotropic cognition moderates blood pressure response to interpersonal stress in high-risk adolescent girls. Int J Psychophysiol. 1998 Mar;28(2):131-42. doi: 10.1016/s0167-8760(97)00091-3.
Results Reference
background
PubMed Identifier
12027031
Citation
Ewart CK, Suchday S. Discovering how urban poverty and violence affect health: development and validation of a Neighborhood Stress Index. Health Psychol. 2002 May;21(3):254-62. doi: 10.1037//0278-6133.21.3.254. Erratum In: Health Psychol. 2002 Sep;21(5):458.
Results Reference
background
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Anger and Cardiovascular Risk in Urban Youth
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