Study of MDX-010 in Stage IV Breast Cancer

Inclusion Criteria: Provide written informed consent diagnosed with Stage IV adenocarcinoma that has progressed despite previous therapy at least 18 years of age measurable disease defined by RECIST must discontinue any alternative therapy used to treat breast cancer at least 4 weeks prior to enrollment and agree to not use such therapies during the duration of the study (patients may continue to receive tamoxifen, bisphosphate therapy and trastuzumab) prior radiation must be completed at least 4 weeks prior to enrollment ECOG performance status of 0-2 Negative pregnancy test Screening lab values must be met Exclusion Criteria: must be disease free from other cancers for at least 5 years symptomatic or untreated brain metastases active or history of autoimmune disease active HIV, HTLV, HBV or HCV infection concurrent medical condition requiring the use of systemic corticosteroids, must be discontinued at least 4 weeks prior to enrollment prior therapy with anti-CTLA-4 antibody significant organ compromise, uncontrolled heart, liver, lung, or renal disease or other serious illness pregnancy or nursing