APAF: Assessment of Cardiac Resynchronization Therapy in Patients With Permanent Atrial Fibrillation
Congestive Heart Failure, Atrial Fibrillation
About this trial
This is an interventional treatment trial for Congestive Heart Failure focused on measuring Heart failure, Atrial fibrillation, Cardiac resynchronization, Cardiac pacing, Catheter ablation, Quality of life, Echocardiography
Eligibility Criteria
Inclusion Criteria: Patients with permanent AF in whom a clinical decision had been made to undertake complete AV junction ablation and ventricular pacing because of drug-refractory, severely symptomatic, uncontrolled high ventricular rate Patients with permanent AF, drug-refractory heart failure, depressed LV function in whom a clinical decision had been made to undertake left ventricular synchronization pacing Exclusion Criteria: New York Heart Association class IV heart failure, or systolic blood pressure ≥80 mmHg Severe concomitant non cardiac disease Need for surgical intervention Myocardial infarction within 3 months Primary hypertrophic cardiomyopathy Arrhythmogenic right ventricular dysplasia Primary valvular heart disease Sustained ventricular tachycardia or ventricular fibrillation Previously implanted pacemaker Inability to obtain reliable RV and LV pacing and persistent AV block
Sites / Locations
- Michele Brignole
- Arcispedale S Maria Nuova
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
1
2
Normal RV pacing
Echo-guided optimization of pacing