Telmisartan-Induced Reduction in Intra-Myocellular Lipids Trial

Inclusion Criteria: Written informed consent Between 30 and 70 years of age Abdominal obesity defined as increased waist circumference (Men >102cm (>40in), Women >88cm (>35in)), with or without any of the following additional criteria of the metabolic syndrome: Triglycerides >=1.7mmol/L (>=150 mg/dL and/or on prescribed lipid lowering medication for > 3 months) HDL cholesterol Men <1.0 mmol/L (<40 mg/dL) Women <1.3 mmol/L (<50 mg/dL) Blood pressure >=130 and/or >=85 mmHg and/or on anti-hypertensive therapy (except ACE-I or ARB) Fasting glucose >=6.1 mmol/L (>=110 mg/dL) Ability and willingness to complete dietary and activity diaries and questionnaires. Exclusion Criteria: Participant has taken ACE inhibitor or ARB in the last 3 months, or in the opinion of the study physician currently has indication for either of these medications Concurrent antidiabetic medication Use of systemic glucocorticosteroids (topical and inhaled are acceptable) On lipid-lowering medication and NOT on stable dose for the last three months If the participant has any one or more of the following medical disorders: diabetes mellitus and/or FBG >=7.0 mmol/L on two separate occasions within the screening period uncontrolled hypertension (SBP >=160 mmHg and/or DBP >=100 mmHg) or known participants with secondary causes of hypertension biliary obstruction hepatic dysfunction as defined by SGPT (ALT) > 3 times the upper limit of normal range renal dysfunction as defined by serum creatinine > 130umol/L AND/OR proteinuria 1+ or greater (dipstick) serum triglycerides >10 mmol/L history of hypertrophic obstructive cardiomyopathy, hemodynamically relevant stenosis of the aortic or mitral valve sodium depletion or hyperkalemia. uncorrected volume depletion endocrine disorder (e.g. hyperthyroidism, Cushing's syndrome, acromegaly, etc.) Participants on thyroid-replacement therapy and TSH < 5.0 mU/L may be enrolled in the study. contraindications to study diet any major surgery that is, at the time of screening, planned to take place during the study period. previously angioedema with ACE Inhibitor or ARB or known hypersensitivity to any component of the study drug formulations (e.g. hereditary fructose intolerance) history of drug or alcohol dependency within six months prior to signing the informed consent form. history of active malignancy, chronic inflammatory disorder, or chronic infections which would interfere with protocol completion. any other medical, social or geographic condition, which, in the opinion of the investigator would not allow safe completion of the protocol and/or safe administration of trial medication If the participant has any contraindications to MRI Pre-menopausal women (last menstruation >=1 year prior to consent) who: are not surgically sterile or are nursing, or pregnant, or are of child-bearing potential and are NOT practicing acceptable methods of birth control, or do NOT plan to continue practicing an acceptable method throughout the study, AND do not agree to periodic pregnancy testing during participation in the study. Intention to go on weight - reducing medications or weight-loss diets during the study period Significant fluctuations in weight over past 3 months(e.g. >10%) Household member currently in study Any investigational drug therapy within one month of signing the informed consent form. Participant has knowledge that he/she will be unable to consume study foods for >2 weeks during treatment phase of study <70% compliant during run-in Unable to reduce total fat consumption to <40% and/or reduce saturated fat consumption to <15% during run-in