Determining the Responsiveness of Intestinal Lipoprotein Production to an Elevation of Plasma Free Fatty Acids
Insulin Resistance
About this trial
This is an interventional diagnostic trial for Insulin Resistance focused on measuring intestinal lipoprotein, very low density lipoprotein, free fatty acids, Apo B48 and Apo B100, triglycerides, Intestinal lipoprotein production
Eligibility Criteria
Inclusion Criteria: Non-diabetic men and women aged 18-65 years old Written informed consent obtained Body mass index (BMI) < 27 kg/m2 Fasting triglycerides < 2.5 mmol/l Waist circumference < 90 cm Fasting blood glucose < 6 mmol/l Haemoglobin above 130 g/L. Exclusion Criteria: Patient has a history of hepatitis/hepatic disease that has been active within the previous 2 years. Any significant active (over the past 12 months) disease of the gastrointestinal, pulmonary, neurological, renal (creatinine [Cr] > 1.5 mg/dL) genitourinary, or hematological systems; or severe uncontrolled treated or untreated hypertension (sitting diastolic blood pressure [BP] > 100 or systolic > 180); or proliferative retinopathy. Fasting blood glucose > 6 mmol/l or known diabetes. Any history of a myocardial infarction (MI) or clinically significant, active, cardiovascular history including a history of arrhythmias or conduction delays on electrocardiogram (ECG), unstable angina, or decompensated heart failure. Any laboratory values: AST > 2x upper limit of normal (ULN); ALT > 2x ULN; thyroid-stimulating hormone (TSH) > 6 mU/l. Known or suspected allergy to the medication or a history of multiple and/or severe allergies to drugs or foods or a history of severe anaphylactic reactions. Current addiction to alcohol or substances of abuse as determined by the investigator. Mental incapacity, unwillingness or language barrier precluding adequate understanding or cooperation Any lipid lowering or hypoglycemic agents Will not donate blood three months before start or three months after completing study. Thrombocytopenia
Sites / Locations
- University Health Network