Phase 2 Study of Association Gemcitabine-Cisplatin to Treat Penis Epidermoid Carcinoma

Inclusion Criteria: Age ≥ 18 years OMS ≤ 2 Penis epidermoid carcinoma histologically proved. Tumor with ganglionic loco-regional injury inextirpable and/or metastatic (M1, all T , all N), at initial diagnostic or at relapse after first treatment with curative aim (surgery and / or radiotherapy) Disease measurable with RECIST criteria Absence of all former chemotherapy during 5 years between inclusion. If former radiotherapy, necessity to have appreciated targets outside the irradiation fields. If former radiotherapy, it must have been done more than 4 weeks before inclusion in the study. Biologicals values required : polynuclear neutrophils ≥ 1500/mm3, blood-platelets ≥ 100000/mm3, Hb ≥ 10 g/dl, Transaminases < 3N, TP ≥ 70%, total bilirubin < 1,5 N, creatinine in the blood ≤ 110 micromoles/l. Normal clearance of creatinine, according to Cockroft and Gault's formulae. Calcemia : normal or anomaly without clinical meaning. Well-informed written consent, signed by the patient. Exclusion Criteria: Uncontrolled cerebral known metastasis All former chemotherapy administration during 5 years between inclusion Other cancer (except baso-cellular cancer of skin correctly treated, or cancerous disease considered with good prognosis and on remission until 5 years at least) Uncontrolled cardiac insufficiency or all other severe and uncontrolled pathology. Peripheric neuropathy ≥ grade 2 OMS Anormal audiogram Patient difficult to follow for geographical, psychological or family reasons. Persons protected by law.