Leptin in Human Energy and Neuroendocrine Homeostasis
Obesity, Weight Loss
About this trial
This is an interventional treatment trial for Obesity focused on measuring Leptin, Obesity, Energy, Autonomics, Neuroendocrine
Eligibility Criteria
Inclusion Criteria: Healthy lean or overweight males and females who have sustained their current weight for at least 6 months. Exclusion Criteria: Pregnancy Any illness or chronic medication that affect energy expenditure, neuroendocrine function, autonomic function or that would impair ability to tolerate a prolonged hospital stay including rapid weight reduction and vigorous exercise.
Sites / Locations
- Columbia University
Arms of the Study
Arm 1
Arm 2
Arm 3
No Intervention
Placebo Comparator
Experimental
Weight initial
Weight -10% placebo
Weight -10% leptin
Subjects undergo studies at their usual body weight which is used as a baseline against which to compare subjects following weight loss with or without leptin repletion.
Subjects are studied while at a 10% reduced body weight and receiving placebo injections for 5 weeks.
Subjects are studied while at a 10% reduced body weight and receiving leptin injections for 5 weeks.