Comparing Efficacy and Safety of Tacrolimus With Steroids or Monoclonal Anti-IL2R Antibody in Hepatitis C Virus (HCV) Positive Liver Transplant Patients (CHASE)

Inclusion Criteria: Patients 18 to 65 years of age who will undergo primary orthotopic liver or split liver allograft transplantation for HCV-cirrhosis are eligible for the study. Patients receiving a cadaveric liver transplant with compatible ABO blood type can be included. Exclusion Criteria: Recipient of multi-organ transplant Recipient of an auxiliary graft Patient is receiving ABO incompatible graft Patients requiring immunosuppressive treatment Patients requiring ongoing corticosteroid therapy. Patient has significant, uncontrolled concomitant infections and/or severe diarrhoea, vomiting, active upper gastro-intestinal tract malabsorption or active peptic ulcer. Patient or donor is known to be HIV positive. Patient is allergic or intolerant to study medication Patient is pregnant or breast-feeding. Patient has been previously enrolled in this study