Exercise Versus Niacin in Patients With Coronary Artery Disease (CAD) and Low High-Density Lipoproteins (HDL)
Coronary Disease, Hypolipoproteinemia
About this trial
This is an interventional treatment trial for Coronary Disease
Eligibility Criteria
Inclusion Criteria: Coronary disease Low HDL cholesterol Age limits (see below) Exclusion Criteria: Unstable angina oder MI within 3 months prior to inclusion CAD with indication for bypass surgery Left main disease ( > 25% stenosis diameter) Ejection fraction < 40% Higher degree heart valve disease Higher degree ventricular arrhythmias Type 1 Diabetes Severe disorders of lipoprotein metabolism (Low-density lipoprotein cholesterol (LDL)> 5.0 mmol/L) Severe liver disease Thyroid disease Alcohol or drug abuse Pregnancy Stroke or Transient Ischemic Attack (TIA) within 3 months prior to inclusion Allergy against niacin oder other ingredient of niaspan Participation in other clinical trial within 30 days prior to inclusion Acute gastric ulcer Arterial bleeding Uncontrolled severe arterial hypertension Treatment with lipid-lowering drug other than Hydroxy-Methylglutaryl Coenzyme A (HMG-CoA)-inhibitor within 3 months prior to inclusion
Sites / Locations
- University of Leipzig Heart Center
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Active Comparator
Placebo Comparator
1
2
3
niacin
physical exercise
control