Humoral Determinants of Immunity to Pneumococcal Infection
Pneumonia, Pneumococcal Infections, Infections, Streptococcus Pneumoniae
About this trial
This is an interventional prevention trial for Pneumonia focused on measuring Pneumococcus, Pneumococcal pneumonia
Eligibility Criteria
Inclusion Criteria: Diagnosis of pneumococcal pneumonia Age matched controls who have not had pneumococcal pneumonia Patients enrolled must be veterans Exclusion Criteria: Patients who do not have the diagnosis of pneumococcal pneumonia based on a clinical syndrome that is consistent with pneumonia and the finding of pneumococcus in blood or sputum or any other sterile site will be excluded Women of child-bearing age will be excluded Patients who have had a prior reaction to pneumococcal vaccine that they describe as 'severe' will be excluded
Sites / Locations
- Michael E. DeBakey VA Medical Center, Houston, TX
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Experimental
PPV-PCV
PCV-PPV
PCV-PCV
PCV only
Patients receive Pneumovax, and 6 months later Prevnar
Patients receive Prevnar, and 6 months later Pneumovax
Patients receive Prevnar, and 6 months later Prevnar again
Patients receive Prevnar only