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A Phase III Study of Apixaban in Patients With Atrial Fibrillation (AVERROES)

Primary Purpose

Atrial Fibrillation

Status

Completed

Phase

Phase 3

Locations

International

Study Type

Interventional

Intervention

Apixaban

Acetylsalicylic acid

About this trial

This is an interventional prevention trial for Atrial Fibrillation

Eligibility Criteria

50 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Key Inclusion Criteria:

Male and female
Age of 50 years or older
Permanent, paroxysmal, or persistent atrial fibrillation (at screening or within 6 months prior to enrollment) documented by 12-lead electrocardiogram)
At least 1 of the following risk factors for stroke:
- Prior stroke or transient ischemic attack
- Age of 75 years or older
- Arterial hypertension on treatment
- Diabetes mellitus
- Heart failure (New York Health Authority Class 2 or greater at time of enrollment)
- Left ventricular ejection fraction of 35% or less, documented within 6 months of enrollment
- Peripheral arterial disease (previous arterial revascularization, limb or foot amputation, or current intermittent claudication with ankle-arm systolic blood pressure ratio <0.9)
Not currently receiving vitamin K antagonist therapy for 1 of the following reasons:
- Previous vitamin K antagonist therapy demonstrated as unsuitable and discontinued
- Vitamin K antagonist therapy not previously used but expected unsuitable

Key Exclusion Criteria:

Women who are pregnant or breast feeding
Women of child bearing potential who are unwilling to meet the study requirements for pregnancy testing or are unwilling or unable to use an acceptable method to avoid pregnancy
Atrial fibrillation due to reversible causes, such as thyrotoxicosis or pericarditis
Valvular disease requiring surgery
Planned ablation procedure for atrial fibrillation to be performed within 3 months
Conditions other than atrial fibrillation that require chronic anticoagulation (such as, prosthetic mechanical heart valve, venous thromboembolism)
Patients with serious bleeding in the last 6 months or at high risk for bleeding, including but not limited to those with:
- Active peptic ulcer disease
- Platelet count <100,000/mm^3 or hemoglobin <10g/dL
- Recent stroke (within 10 days)
- Documented hemorrhagic tendencies or blood dyscrasias
Current alcohol or drug abuse or psychosocial reasons that make study participation impractical
Severe comorbid condition with life expectancy <1 year
Severe renal insufficiency; any patient with a serum creatinine level >2.5 mg/dL or a calculated creatinine clearance <25 mL/min is excluded
Alanine transaminase or aspartate aminotransferase levels >2 times upper limit of normal (ULN) or a total bilirubin level >1.5 times ULN (unless an alternative causative factor [such as Gilbert's syndrome] is identified)
Allergy or adverse reaction to acetylsalicylic acid
Required treatment with a thienopyridine (clopidogrel or ticlopidine)
Prisoners or participants who are compulsory detained (involuntarily incarcerated)
Use of an investigational drug or device within the past 30 days or prior randomization into an apixaban clinical study
Patients who are compulsorily detained for treatment for a psychiatric or physical illness

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Active Comparator

Arm Label

Apixaban

Acetylasalicylic acid

Arm Description

Outcomes

Primary Outcome Measures

Event Rate of Stroke/Systemic Embolism During the Intended-treatment Period

Event rate=percent of participants with an event divided by the total participants in the arm. Intended-treatment period=date of randomization to the efficacy cutoff date, which was to be the date on which at least 226 unrefuted original primary efficacy events occurred (date revised to May 28, 2010 following cessation of study for superior efficacy.)

Secondary Outcome Measures

Event Rate for the Composite of Stroke of Any Type, Systemic Embolism, Myocardial Infarction, or Vascular Death During the Double-blind Treatment Period

Event rate=percent of participants with an event divided by the total participants in the arm.

Event Rate of All-cause Death; Net Clinical Benefit-Composite of Stroke, Systemic Embolism, Myocardial Infarction, Vascular Death, and Major Bleeding; and Vascular Death

Event rate=percent of participants with an event divided by the total participants in the arm.

Event Rates for Major Bleeding, Major or Clinically Relevant Nonmajor (CNRM) Bleeding, and All Bleeding in the Double-blind Period

Event rate=percent of participants with an event divided by the total participants in the arm.

Rate of Unrefuted Bleeding From First Dose of Double-blind Study Drug to First Occurence of Unrefuted Bleeding During the Double-blind Treatment Period

Event rate=percent of participants with an event divided by the total participants in the arm.

Number of Participants With Serious Adverse Events (SAEs), Adverse Events (AEs), Bleeding AEs, Discontinuations Due to AEs, and Death as Outcome

AE=any new unfavorable symptom, sign, or disease or worsening of a preexisting condition that may not have a causal relationship with treatment. SAE=a medical event that at any dose results in death, persistent or significant disability/incapacity, or drug dependency/abuse; is life-threatening, an important medical event, or a congenital anomaly/birth defect; or requires or prolongs hospitalization.

Number of Participants With Laboratory Test Results Meeting the Criteria for Marked Abnormality

BL=baseline, LLN=lower limit of normal, ULN=upper limit of normal. Hemoglobin (g/dL), low: BL>2 or value ≤8; hematocrit(%), low: <0.75*BL; erythrocytes (*10^6 cells/μL), low: <0.75*BL; platelet count (*10^9 cells/L),low: <100*10^9 cells/L; leukocytes (*10^3 cells/μL), low if <0.8*BL and BL<LLN or <LLN and BL >ULN or <0.75*LLN when BL is missing or LLN ≤BL≤ ULN, high if >1.2*BL and BL>ULN or >ULN when BL and BL<LLN or >1.25*ULN when BL is missing or LLN≤BL≤ULN; neutrophils (absolute), low: <1.0*10^3 cells/μL; eosinophils (absolute), high: >0.750*10^3 cells/μL; basophils (absolute), high: >0.4*10^3 cells/μL; monocytes (absolute), high: 2*10^3 cells/μL; lymphocytes (absolute), low if <0.75*10^3 cells/μL, high if >7.50*10^3 cells/μL; ALP (U/L), high: 2*ULN; AST (U/L), high: 3*ULN; AST (U/L), high: 3*ULN; bilirubin, total (mg/dL), high: >2*ULN; bilirubin, direct (mg/dL), high: 1.5*ULN; BUN (mg/dL), high:>2*ULN; creatinine (mg/dL), high: >1.5*ULN.

Number of Participants With Laboratory Test Results Meeting the Criteria for Marked Abnormality (Continued)

LLN=lower limit of normal; ULN=upper limit of normal; BL=baseline. Sodium, serum (mEq/L):low if <0.95*BL and BL<LLN or <LLN and BL>ULN or <0.95*LLN when BL missing or LLN ≤BL≤ULN, high if >1.05*BL and BL>ULN or >ULN and BL<LLN or >1.05*ULN when BL missing or LLN≤BL≤ULN; potassium(mEq/L):low if <0.90*BL and BL<LLN or <LLN and BL>ULN or <0.90*LLN if BL missing or LLN≤BL≤ULN, high if >1.10*BL and BL>ULN or>ULN and BL<LLN or >1.10*ULN when BL missing or LLN≤BL≤ULN; chloride(mEq/L):low if <0.90*BL and BL<LLN or <LLN and BL>ULN or <0.90*LLN if BL missing or LLN≤BL ≤ULN, high if >1.10*BL and BL>ULN or >ULN and BL<LLN or >1.10* ULN if BL missing or LLN≤BL≤ULN; calcium(mg/dL):low if <0.75*BL and BL<LLN or <LLN and BL>ULN or <0.80*LLN if BL missing or LLN≤BL≤ULN, high if >1.25*BL and BL>ULN or >ULN if BL<LLN or >1.20*ULN if BL missing or LLN≤BL≤ULN ; bicarbonate(mEq/L):low if <0.75*BL when BL<LLN or <LLN when BL>ULN or <0.75*LLN if BL missing or LLN≤BL≤ULN, high if >1.25*BL when BL>ULN or >ULN

Number of Participants With Laboratory Test Results Meeting the Criteria for Marked Abnormality (Continued)

ULN=upper limit of normal; LLN=lower limit of normal; BL=baseline. Creatine kinase (U/L), high:>5*ULN; protein, total(g/L):low if <0.90*BL when BL<LLN or <LLN when B >ULN or <0.90*LLN when BL is missing or LLN≤BL≤ULN, high if >1.10*BL if BL>ULN or >ULN when BL<LLN or >1.10*ULN if BL missing or LLN≤BL≤ULN.Protein,total(g/L): low if <0.90*BL if BL<LLN or <LLN if BL>ULN or <0.90*LLN if BL missing or LLN≤BL≤ULN, high if >1.10*BL if BL>ULN or >ULN if BL<LLN or >1.10*ULN if BL or LLN≤BL≤ULN; glucose, serum fasting (mg/dL): low if <0.8*BL if BL<LLN or <LLN when BL>ULN or <0.8*LLN when BL missing or LLN≤BL≤ULN, high if >2*BL when BL>ULN or >ULN when BL<LLN or >1.5*ULN if BL missing or LLN≤BL≤ULN; uric acid (mg/dL), high: >2*BL and BL>ULN or>1.5*ULN when BL missing or BL≤ULN; glucose, urine, high; protein, urine, high; blood, urine, high; leukocyte esterase, urine, high; RBC count, urine (Hpf), high; WBC count, urine (Hpf), high: ≥2 if BL=missing,=0 or =0.5 or if ≥3 if BL=1, or if ≥4 and BL≥2.

Full Information

NCT ID

NCT00496769

First Posted

July 2, 2007

Last Updated

May 16, 2018

Sponsor

Bristol-Myers Squibb

Collaborators

Pfizer

1. Study Identification

Unique Protocol Identification Number

NCT00496769

Brief Title

A Phase III Study of Apixaban in Patients With Atrial Fibrillation

Acronym

AVERROES

Official Title

Apixaban Versus Acetylsalicylic Acid (ASA) to Prevent Stroke in Atrial Fibrillation Patients Who Have Failed or Are Unsuitable for Vitamin K Antagonist Treatment: A Randomized Double-blind Trial

Study Type

Interventional

2. Study Status

Record Verification Date

May 2018

Overall Recruitment Status

Completed

Study Start Date

August 31, 2007 (Actual)

Primary Completion Date

November 30, 2010 (Actual)

Study Completion Date

May 25, 2017 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

Bristol-Myers Squibb

Collaborators

Pfizer

4. Oversight

Data Monitoring Committee

Yes

5. Study Description

Brief Summary

The purpose of this clinical research study is to determine whether apixaban is more effective than acetylsalicylic acid in the prevention of strokes associated with patients with atrial fibrillation. The safety of this treatment will also be studied.

Detailed Description

An optional Long-term Open-label Extension Phase of treatment with apixaban will be provided for qualifying participants following the conclusion of the double-blind phase

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Atrial Fibrillation

7. Study Design

Primary Purpose

Prevention

Study Phase

Phase 3

Interventional Study Model

Parallel Assignment

Masking

ParticipantInvestigator

Allocation

Randomized

Enrollment

6421 (Actual)

8. Arms, Groups, and Interventions

Arm Title

Apixaban

Arm Type

Experimental

Arm Title

Acetylasalicylic acid

Arm Type

Active Comparator

Intervention Type

Drug

Intervention Name(s)

Apixaban

Other Intervention Name(s)

BMS-562247

Intervention Description

Tablets, oral, 5 mg (2.5 mg in patients meeting any 2 of the following criteria: 80 years of age and older, weight of 60 kilograms or less, and a serum creatinine level of 1.5 mg/dL or higher), twice daily, up to 156 weeks

Intervention Type

Drug

Intervention Name(s)

Acetylsalicylic acid

Intervention Description

Tablets, oral, 81-324 mg, once daily, up to 156 weeks

Primary Outcome Measure Information:

Title

Event Rate of Stroke/Systemic Embolism During the Intended-treatment Period

Description

Time Frame

Randomization to efficacy cutoff date of May 28, 2010 (date revised following cessation of study for superior efficacy)

Secondary Outcome Measure Information:

Title

Event Rate for the Composite of Stroke of Any Type, Systemic Embolism, Myocardial Infarction, or Vascular Death During the Double-blind Treatment Period

Description

Event rate=percent of participants with an event divided by the total participants in the arm.

Time Frame

Randomization to efficacy cutoff date of May 28, 2010 (date revised following cessation of study for superior efficacy)

Title

Event Rate of All-cause Death; Net Clinical Benefit-Composite of Stroke, Systemic Embolism, Myocardial Infarction, Vascular Death, and Major Bleeding; and Vascular Death

Description

Event rate=percent of participants with an event divided by the total participants in the arm.

Time Frame

Randomization to efficacy cutoff date of May 28, 2010 (date revised following cessation of study for superior efficacy)

Title

Event Rates for Major Bleeding, Major or Clinically Relevant Nonmajor (CNRM) Bleeding, and All Bleeding in the Double-blind Period

Description

Event rate=percent of participants with an event divided by the total participants in the arm.

Time Frame

First dose of study drug (Day 1) to the earlier of a patient's discontinuation of double-blind study drug or the attainment of at least 226 primary efficacy events up to May 28, 2010

Title

Rate of Unrefuted Bleeding From First Dose of Double-blind Study Drug to First Occurence of Unrefuted Bleeding During the Double-blind Treatment Period

Description

Event rate=percent of participants with an event divided by the total participants in the arm.

Time Frame

Day 1 to first bleeding event up to efficacy cutoff date of May 28, 2010 (date revised following cessation of study for superior efficacy)

Title

Number of Participants With Serious Adverse Events (SAEs), Adverse Events (AEs), Bleeding AEs, Discontinuations Due to AEs, and Death as Outcome

Description

Time Frame

First dose of study drug (Day 1) to 30 days after last dose of blinded study drug

Title

Number of Participants With Laboratory Test Results Meeting the Criteria for Marked Abnormality

Description

Time Frame

First dose of study drug (Day 1) to 30 days after last dose of blinded study drug

Title

Number of Participants With Laboratory Test Results Meeting the Criteria for Marked Abnormality (Continued)

Description

Time Frame

First dose of study drug (Day 1) to 30 days after last dose of blinded study drug

Title

Number of Participants With Laboratory Test Results Meeting the Criteria for Marked Abnormality (Continued)

Description

Time Frame

First dose of study drug (Day 1) to 30 days after last dose of blinded study drug

10. Eligibility

Sex

All

Minimum Age & Unit of Time

50 Years

Accepts Healthy Volunteers

Eligibility Criteria

Key Inclusion Criteria: Male and female Age of 50 years or older Permanent, paroxysmal, or persistent atrial fibrillation (at screening or within 6 months prior to enrollment) documented by 12-lead electrocardiogram) At least 1 of the following risk factors for stroke: Prior stroke or transient ischemic attack Age of 75 years or older Arterial hypertension on treatment Diabetes mellitus Heart failure (New York Health Authority Class 2 or greater at time of enrollment) Left ventricular ejection fraction of 35% or less, documented within 6 months of enrollment Peripheral arterial disease (previous arterial revascularization, limb or foot amputation, or current intermittent claudication with ankle-arm systolic blood pressure ratio <0.9) Not currently receiving vitamin K antagonist therapy for 1 of the following reasons: Previous vitamin K antagonist therapy demonstrated as unsuitable and discontinued Vitamin K antagonist therapy not previously used but expected unsuitable Key Exclusion Criteria: Women who are pregnant or breast feeding Women of child bearing potential who are unwilling to meet the study requirements for pregnancy testing or are unwilling or unable to use an acceptable method to avoid pregnancy Atrial fibrillation due to reversible causes, such as thyrotoxicosis or pericarditis Valvular disease requiring surgery Planned ablation procedure for atrial fibrillation to be performed within 3 months Conditions other than atrial fibrillation that require chronic anticoagulation (such as, prosthetic mechanical heart valve, venous thromboembolism) Patients with serious bleeding in the last 6 months or at high risk for bleeding, including but not limited to those with: Active peptic ulcer disease Platelet count <100,000/mm^3 or hemoglobin <10g/dL Recent stroke (within 10 days) Documented hemorrhagic tendencies or blood dyscrasias Current alcohol or drug abuse or psychosocial reasons that make study participation impractical Severe comorbid condition with life expectancy <1 year Severe renal insufficiency; any patient with a serum creatinine level >2.5 mg/dL or a calculated creatinine clearance <25 mL/min is excluded Alanine transaminase or aspartate aminotransferase levels >2 times upper limit of normal (ULN) or a total bilirubin level >1.5 times ULN (unless an alternative causative factor [such as Gilbert's syndrome] is identified) Allergy or adverse reaction to acetylsalicylic acid Required treatment with a thienopyridine (clopidogrel or ticlopidine) Prisoners or participants who are compulsory detained (involuntarily incarcerated) Use of an investigational drug or device within the past 30 days or prior randomization into an apixaban clinical study Patients who are compulsorily detained for treatment for a psychiatric or physical illness

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Bristol-Myers Squibb

Organizational Affiliation

Bristol-Myers Squibb

Official's Role

Study Director

Facility Information:

Facility Name

Mobile Heart Specialists, Pc

City

Mobile

State/Province

Alabama

ZIP/Postal Code

36608

Country

United States

Facility Name

Southwest Heart

City

Tucson

State/Province

Arizona

ZIP/Postal Code

85710

Country

United States

Facility Name

Cardiology Consultants Of Orange County Med. Group Inc

City

Anaheim

State/Province

California

ZIP/Postal Code

92801

Country

United States

Facility Name

Kaiser Permanente Medical Center, West Los Angeles

City

Los Angeles

State/Province

California

ZIP/Postal Code

90034

Country

United States

Facility Name

Desert Med Grp Inc, Dba Desert Oasis Healthcare Med Group

City

Palm Springs

State/Province

California

ZIP/Postal Code

92262

Country

United States

Facility Name

Yogesh K. Paliwal Md

City

Pomona

State/Province

California

ZIP/Postal Code

91767

Country

United States

Facility Name

San Diego Managed Care Group

City

Poway

State/Province

California

ZIP/Postal Code

92064

Country

United States

Facility Name

University Of California, San Diego

City

San Diego

State/Province

California

ZIP/Postal Code

92103

Country

United States

Facility Name

Santa Rosa Cardiology

City

Santa Rosa

State/Province

California

ZIP/Postal Code

95405

Country

United States

Facility Name

North County Internal Medicine

City

Vista

State/Province

California

ZIP/Postal Code

92083

Country

United States

Facility Name

Cardiology Associates Of New Haven,Pc

City

Guilford

State/Province

Connecticut

ZIP/Postal Code

06437

Country

United States

Facility Name

Stamford Therapeutics Consortium

City

Stamford

State/Province

Connecticut

ZIP/Postal Code

06905

Country

United States

Facility Name

Bay Pines Va Healthcare System

City

Bay Pines

State/Province

Florida

ZIP/Postal Code

33744

Country

United States

Facility Name

Research Alliance, Inc.

City

Clearwater

State/Province

Florida

ZIP/Postal Code

33756

Country

United States

Facility Name

The Heart & Vascular Institute Of Florida

City

Clearwater

State/Province

Florida

ZIP/Postal Code

33756

Country

United States

Facility Name

Kim A. Klancke, Md

City

Daytona Beach

State/Province

Florida

ZIP/Postal Code

32114

Country

United States

Facility Name

The Heart Group Pl

City

Fort Myers

State/Province

Florida

ZIP/Postal Code

33908

Country

United States

Facility Name

Baptist Heart Specialists

City

Jacksonville Beach

State/Province

Florida

ZIP/Postal Code

32250

Country

United States

Facility Name

St. Vincent'S Ambulatory Care, Inc

City

Jacksonville

State/Province

Florida

ZIP/Postal Code

32204

Country

United States

Facility Name

Michael F. Lesser, Md, Facc Osler Medical Inc.

City

Melbourne

State/Province

Florida

ZIP/Postal Code

32901

Country

United States

Facility Name

Cardiovascular Center Of Sarasota

City

Sarasota

State/Province

Florida

ZIP/Postal Code

34239

Country

United States

Facility Name

The Broward Heart Group, Pa

City

Tamarac

State/Province

Florida

ZIP/Postal Code

33321

Country

United States

Facility Name

Southeast Regional Research Group

City

Columbus

State/Province

Georgia

ZIP/Postal Code

31904

Country

United States

Facility Name

Southeast Regional Research Group

City

Savannah

State/Province

Georgia

ZIP/Postal Code

31406

Country

United States

Facility Name

Fox Valley Clinical Research Center, Llc

City

Aurora

State/Province

Illinois

ZIP/Postal Code

60504

Country

United States

Facility Name

North Chicago Va Medical Center

City

North Chicago

State/Province

Illinois

ZIP/Postal Code

60064

Country

United States

Facility Name

Indiana Heart Physicians, Inc.

City

Indianapolis

State/Province

Indiana

ZIP/Postal Code

46237

Country

United States

Facility Name

The Care Group, Llc

City

Indianapolis

State/Province

Indiana

ZIP/Postal Code

46290

Country

United States

Facility Name

Hutchinson Clinic, Pa

City

Hutchinson

State/Province

Kansas

ZIP/Postal Code

67502

Country

United States

Facility Name

Dr. Jeffrey Chen

City

Lafayette

State/Province

Louisiana

ZIP/Postal Code

70506

Country

United States

Facility Name

Peninsula Cardiology Associates, P.A.

City

Salisbury

State/Province

Maryland

ZIP/Postal Code

21804

Country

United States

Facility Name

Pentucket Medical Associates

City

Haverhill

State/Province

Massachusetts

ZIP/Postal Code

01830

Country

United States

Facility Name

Great Lakes Heart Center Of Alpena

City

Alpena

State/Province

Michigan

ZIP/Postal Code

49707

Country

United States

Facility Name

Henry Ford Hospital K-15

City

Detroit

State/Province

Michigan

ZIP/Postal Code

48202

Country

United States

Facility Name

Michigan Heart And Vascular Specialists

City

Petoskey

State/Province

Michigan

ZIP/Postal Code

49770

Country

United States

Facility Name

Academic Cardiology Associates

City

Rochester Hills

State/Province

Michigan

ZIP/Postal Code

48307

Country

United States

Facility Name

Tupelo Neurology Clinic, Pa

City

Tupelo

State/Province

Mississippi

ZIP/Postal Code

38801

Country

United States

Facility Name

Missouri Cardiovascular Specialists

City

Columbia

State/Province

Missouri

ZIP/Postal Code

65201

Country

United States

Facility Name

University Of Missouri

City

Columbia

State/Province

Missouri

ZIP/Postal Code

65212

Country

United States

Facility Name

Glacier View Cardiology, Pc

City

Kalispell

State/Province

Montana

ZIP/Postal Code

59901

Country

United States

Facility Name

Hunterdon Cardiovascular Associates

City

Flemington

State/Province

New Jersey

ZIP/Postal Code

08822

Country

United States

Facility Name

Capital Cardiology Associates

City

Albany

State/Province

New York

ZIP/Postal Code

12211

Country

United States

Facility Name

Nyu Hudson Valley Cardiology

City

Cortlandt Manor

State/Province

New York

ZIP/Postal Code

10567

Country

United States

Facility Name

Long Island Heart Associates

City

Mineola

State/Province

New York

ZIP/Postal Code

11501

Country

United States

Facility Name

Dr William Kufs

City

Saratoga Springs

State/Province

New York

ZIP/Postal Code

12866

Country

United States

Facility Name

Capital Cardiology Associates

City

Troy

State/Province

New York

ZIP/Postal Code

12180

Country

United States

Facility Name

Terry V. Arnold, Md

City

Lexington

State/Province

North Carolina

ZIP/Postal Code

27293

Country

United States

Facility Name

Pinehurst Medical Clinic, Inc

City

Pinehurst

State/Province

North Carolina

ZIP/Postal Code

28374

Country

United States

Facility Name

Sanford Cardiology

City

Sanford

State/Province

North Carolina

ZIP/Postal Code

27330

Country

United States

Facility Name

Ira R. Friedlander, M.D.

City

Canton

State/Province

Ohio

ZIP/Postal Code

44710

Country

United States

Facility Name

Davis Heart & Lung Research Institute

City

Columbus

State/Province

Ohio

ZIP/Postal Code

43210

Country

United States

Facility Name

Integris Cardiovascular Physicians

City

Oklahoma City

State/Province

Oklahoma

ZIP/Postal Code

73112

Country

United States

Facility Name

South Oklahoma Heart Research

City

Oklahoma City

State/Province

Oklahoma

ZIP/Postal Code

73135

Country

United States

Facility Name

Oregon Medical Group - Clinical Research

City

Eugene

State/Province

Oregon

ZIP/Postal Code

97401

Country

United States

Facility Name

Hillsboro Cardiology Pc

City

Hillsboro

State/Province

Oregon

ZIP/Postal Code

97123

Country

United States

Facility Name

The Portland Clinic, Llp

City

Portland

State/Province

Oregon

ZIP/Postal Code

97205

Country

United States

Facility Name

Comprehensive Cardiology Consultants

City

Langhorne

State/Province

Pennsylvania

ZIP/Postal Code

19047

Country

United States

Facility Name

Grand View - Lehigh Valley Health Services

City

Sellersville

State/Province

Pennsylvania

ZIP/Postal Code

18960

Country

United States

Facility Name

West Chester Cardiology

City

West Chester

State/Province

Pennsylvania

ZIP/Postal Code

19380

Country

United States

Facility Name

Cardiology Consultants Of Philadelphia

City

Yardley

State/Province

Pennsylvania

ZIP/Postal Code

19067

Country

United States

Facility Name

Lowcountry Medical Group, Llc

City

Beaufort

State/Province

South Carolina

ZIP/Postal Code

29906

Country

United States

Facility Name

Medical University Of South Carolina

City

Charleston

State/Province

South Carolina

ZIP/Postal Code

29425

Country

United States

Facility Name

Internal Medicine Of Greer

City

Greer

State/Province

South Carolina

ZIP/Postal Code

29650

Country

United States

Facility Name

Knoxville Heart Group

City

Knoxville

State/Province

Tennessee

ZIP/Postal Code

37916

Country

United States

Facility Name

Sentara York Clinical Research

City

Norfolk

State/Province

Virginia

ZIP/Postal Code

23510

Country

United States

Facility Name

Roanoke Heart Institute, Plc

City

Roanoke

State/Province

Virginia

ZIP/Postal Code

24014

Country

United States

Facility Name

Salem Veterans Administration Medical Center

City

Salem

State/Province

Virginia

ZIP/Postal Code

24153

Country

United States

Facility Name

Walla Walla Clinic

City

Walla Walla

State/Province

Washington

ZIP/Postal Code

99362

Country

United States

Facility Name

Marshfield Clinic

City

Marshfield

State/Province

Wisconsin

ZIP/Postal Code

54449

Country

United States

Facility Name

Local Institution

City

Adrogue

State/Province

Buenos Aires

ZIP/Postal Code

1846

Country

Argentina

Facility Name

Local Institution

City

Autonoma Buenos Aires

State/Province

Buenos Aires

ZIP/Postal Code

C1119ACN

Country

Argentina

Facility Name

Local Institution

City

Bahia Blanca

State/Province

Buenos Aires

ZIP/Postal Code

B8000FTD

Country

Argentina

Facility Name

Local Institution

City

Coronel Suarez

State/Province

Buenos Aires

ZIP/Postal Code

B7540GHD

Country

Argentina

Facility Name

Local Institution

City

Haedo

State/Province

Buenos Aires

ZIP/Postal Code

B1706AJU

Country

Argentina

Facility Name

Local Institution

City

La Plata

State/Province

Buenos Aires

ZIP/Postal Code

B1900AXI

Country

Argentina

Facility Name

Local Institution

City

La Plata

State/Province

Buenos Aires

ZIP/Postal Code

B1902COS

Country

Argentina

Facility Name

Local Institution

City

Mar Del Plata

State/Province

Buenos Aires

ZIP/Postal Code

B7600FZN

Country

Argentina

Facility Name

Local Institution

City

Merlo

State/Province

Buenos Aires

ZIP/Postal Code

B1722COV

Country

Argentina

Facility Name

Local Institution

City

Ramos Mejia

State/Province

Buenos Aires

ZIP/Postal Code

B1704ETD

Country

Argentina

Facility Name

Local Institution

City

San Francisco

State/Province

Cordoba

ZIP/Postal Code

X2400MHC

Country

Argentina

Facility Name

Local Institution

City

San Salvador De Jujuy

State/Province

Jujuy

ZIP/Postal Code

Y4600ABF

Country

Argentina

Facility Name

Local Institution

City

Zarate

State/Province

Provincia Buenos Aires

ZIP/Postal Code

B2800DGH

Country

Argentina

Facility Name

Local Institution

City

Rosario

State/Province

Santa FE

ZIP/Postal Code

2000

Country

Argentina

Facility Name

Local Institution

City

Rosario

State/Province

Santa FE

ZIP/Postal Code

S2000CVB

Country

Argentina

Facility Name

Local Institution

City

Rosario

State/Province

Santa FE

ZIP/Postal Code

S2001ODA

Country

Argentina

Facility Name

Local Institution

City

San Miguel De Tucuman

State/Province

Tucuman

ZIP/Postal Code

T4000ICL

Country

Argentina

Facility Name

Local Institution

City

San Miguel De Tucuman

State/Province

Tucuman

ZIP/Postal Code

T4000JCU

Country

Argentina

Facility Name

Local Institution

City

Buenos Aires

ZIP/Postal Code

1221

Country

Argentina

Facility Name

Local Institution

City

Cordoba

ZIP/Postal Code

5000

Country

Argentina

Facility Name

Local Institution

City

Cordoba

ZIP/Postal Code

5016

Country

Argentina

Facility Name

Local Institution

City

Cordoba

ZIP/Postal Code

X5000AAX

Country

Argentina

Facility Name

Local Institution

City

Cordoba

ZIP/Postal Code

X5000EPU

Country

Argentina

Facility Name

Local Institution

City

Cordoba

ZIP/Postal Code

X5000EVQ

Country

Argentina

Facility Name

Local Institution

City

Cordoba

ZIP/Postal Code

X5009BSN

Country

Argentina

Facility Name

Local Institution

City

Corrientes

ZIP/Postal Code

3400

Country

Argentina

Facility Name

Local Institution

City

Salta

ZIP/Postal Code

A4406CLA

Country

Argentina

Facility Name

Local Institution

City

Santa Fe

ZIP/Postal Code

3000

Country

Argentina

Facility Name

Local Institution

City

Coffs Harbour

State/Province

New South Wales

ZIP/Postal Code

2450

Country

Australia

Facility Name

Local Institution

City

Concord

State/Province

New South Wales

ZIP/Postal Code

2139

Country

Australia

Facility Name

Local Institution

City

Gosford

State/Province

New South Wales

ZIP/Postal Code

2250

Country

Australia

Facility Name

Local Institution

City

Kingswood

State/Province

New South Wales

ZIP/Postal Code

2747

Country

Australia

Facility Name

Local Institution

City

Auchenflower

State/Province

Queensland

ZIP/Postal Code

4066

Country

Australia

Facility Name

Local Institution

City

Kippa Ring

State/Province

Queensland

ZIP/Postal Code

4021

Country

Australia

Facility Name

Local Institution

City

Milton

State/Province

Queensland

ZIP/Postal Code

4064

Country

Australia

Facility Name

Local Institution

City

Woolloongabba

State/Province

Queensland

ZIP/Postal Code

4102

Country

Australia

Facility Name

Local Institution

City

Geelong

State/Province

Victoria

ZIP/Postal Code

3220

Country

Australia

Facility Name

Local Institution

City

Joondalup

State/Province

Western Australia

ZIP/Postal Code

6027

Country

Australia

Facility Name

Local Institution

City

Graz

ZIP/Postal Code

8036

Country

Austria

Facility Name

Local Institution

City

Linz

ZIP/Postal Code

4020

Country

Austria

Facility Name

Local Institution

City

Oberpullendorf

ZIP/Postal Code

7350

Country

Austria

Facility Name

Local Institution

City

Salzburg

ZIP/Postal Code

5020

Country

Austria

Facility Name

Local Institution

City

Aalst

ZIP/Postal Code

9300

Country

Belgium

Facility Name

Local Institution

City

Brasschaat

ZIP/Postal Code

2930

Country

Belgium

Facility Name

Local Institution

City

Brussel

ZIP/Postal Code

1090

Country

Belgium

Facility Name

Local Institution

City

Bruxelles

ZIP/Postal Code

1070

Country

Belgium

Facility Name

Local Institution

City

De Pinte

ZIP/Postal Code

9840

Country

Belgium

Facility Name

Local Institution

City

Genk

ZIP/Postal Code

3600

Country

Belgium

Facility Name

Local Institution

City

Huy

ZIP/Postal Code

4500

Country

Belgium

Facility Name

Local Institution

City

Roeselare

ZIP/Postal Code

8800

Country

Belgium

Facility Name

Local Institution

City

Turnhout

ZIP/Postal Code

2300

Country

Belgium

Facility Name

Local Institution

City

Salvador

State/Province

Bahia

ZIP/Postal Code

40144

Country

Brazil

Facility Name

Local Institution

City

Salvador

State/Province

Bahia

ZIP/Postal Code

41810

Country

Brazil

Facility Name

Local Institution

City

Belo Horizonte

State/Province

Minas Gerais

ZIP/Postal Code

30150

Country

Brazil

Facility Name

Local Institution

City

Uberaba

State/Province

Minas Gerais

ZIP/Postal Code

38010

Country

Brazil

Facility Name

Local Institution

City

Uberaba

State/Province

Minas Gerais

ZIP/Postal Code

38025

Country

Brazil

Facility Name

Local Institution

City

Campina Grande Do Sul

State/Province

Parana

ZIP/Postal Code

83430

Country

Brazil

Facility Name

Local Institution

City

Curitiba

State/Province

Parana

ZIP/Postal Code

80010

Country

Brazil

Facility Name

Local Institution

City

Curitiba

State/Province

Parana

ZIP/Postal Code

80730

Country

Brazil

Facility Name

Local Institution

City

Maringa

State/Province

Parana

ZIP/Postal Code

87015

Country

Brazil

Facility Name

Local Institution

City

Belem

State/Province

Para

ZIP/Postal Code

66087

Country

Brazil

Facility Name

Local Institution

City

Natal

State/Province

Rio Grande Do Norte

ZIP/Postal Code

59020

Country

Brazil

Facility Name

Local Institution

City

Porto Alegre

State/Province

Rio Grande Do Sul

ZIP/Postal Code

90020

Country

Brazil

Facility Name

Local Institution

City

Porto Alegre

State/Province

Rio Grande Do Sul

ZIP/Postal Code

90035

Country

Brazil

Facility Name

Local Institution

City

Porto Alegre

State/Province

Rio Grande Do Sul

ZIP/Postal Code

90110

Country

Brazil

Facility Name

Local Institution

City

Porto Alegre

State/Province

Rio Grande Do Sul

ZIP/Postal Code

90610

Country

Brazil

Facility Name

Local Institution

City

Porto Alegre

State/Province

Rio Grande Do Sul

ZIP/Postal Code

90620

Country

Brazil

Facility Name

Local Institution

City

Porto Alegre

State/Province

Rio Grande Do Sul

ZIP/Postal Code

91350

Country

Brazil

Facility Name

Local Institution

City

Blumenau

State/Province

Santa Catarina

ZIP/Postal Code

89010

Country

Brazil

Facility Name

Local Institution

City

Sao Jose

State/Province

Santa Catarina

ZIP/Postal Code

88103

Country

Brazil

Facility Name

Local Institution

City

Botucatu

State/Province

Sao Paulo

ZIP/Postal Code

18600

Country

Brazil

Facility Name

Local Institution

City

Campinas

State/Province

Sao Paulo

ZIP/Postal Code

13059

Country

Brazil

Facility Name

Local Institution

City

Marilia

State/Province

Sao Paulo

ZIP/Postal Code

17515

Country

Brazil

Facility Name

Local Institution

City

Marilia

State/Province

Sao Paulo

ZIP/Postal Code

17519

Country

Brazil

Facility Name

Local Institution

City

San Jose- Do Rio Preto

State/Province

Sao Paulo

ZIP/Postal Code

15015

Country

Brazil

Facility Name

Local Institution

City

Sao Jose Do Rio Preto

State/Province

Sao Paulo

ZIP/Postal Code

15015

Country

Brazil

Facility Name

Local Institution

City

Sao Jose Do Rio Preto

State/Province

Sao Paulo

ZIP/Postal Code

15025

Country

Brazil

Facility Name

Local Institution

City

Sao Jose Do Rio Preto

State/Province

Sao Paulo

ZIP/Postal Code

15090

Country

Brazil

Facility Name

Local Institution

City

Rio De Janeiro

ZIP/Postal Code

20551

Country

Brazil

Facility Name

Local Institution

City

Sao Paulo

ZIP/Postal Code

040112-180

Country

Brazil

Facility Name

Local Institution

City

Sao Paulo

ZIP/Postal Code

04012

Country

Brazil

Facility Name

Local Institution

City

Sao Paulo

ZIP/Postal Code

04038

Country

Brazil

Facility Name

Local Institution

City

Sao Paulo

ZIP/Postal Code

05403

Country

Brazil

Facility Name

Local Institution

City

New Westminster

State/Province

British Columbia

ZIP/Postal Code

V3L 3W4

Country

Canada

Facility Name

Local Institution

City

Winnipeg

State/Province

Manitoba

ZIP/Postal Code

R2V 4W3

Country

Canada

Facility Name

Local Institution

City

Brampton

State/Province

Ontario

ZIP/Postal Code

L6W 2X7

Country

Canada

Facility Name

Local Institution

City

Burlington

State/Province

Ontario

ZIP/Postal Code

L7M 4Y1

Country

Canada

Facility Name

Local Institution

City

Cambridge

State/Province

Ontario

ZIP/Postal Code

N1R 6V6

Country

Canada

Facility Name

Local Institution

City

Cambridge

State/Province

Ontario

ZIP/Postal Code

N1R 7R1

Country

Canada

Facility Name

Local Institution

City

Grimsby

State/Province

Ontario

ZIP/Postal Code

L3M 1P3

Country

Canada

Facility Name

Local Institution

City

Hamilton

State/Province

Ontario

ZIP/Postal Code

L8L 2X2

Country

Canada

Facility Name

Local Institution

City

Hamilton

State/Province

Ontario

ZIP/Postal Code

L8M 1K7

Country

Canada

Facility Name

Local Institution

City

Oshawa,

State/Province

Ontario

ZIP/Postal Code

L1J 2J9

Country

Canada

Facility Name

Local Institution

City

Oshawa

State/Province

Ontario

ZIP/Postal Code

L1H 1B9

Country

Canada

Facility Name

Local Institution

City

Ottawa

State/Province

Ontario

ZIP/Postal Code

K1Y 4W7

Country

Canada

Facility Name

Local Institution

City

Sarnia

State/Province

Ontario

ZIP/Postal Code

N7T 4X3

Country

Canada

Facility Name

Local Institution

City

Sudbury

State/Province

Ontario

ZIP/Postal Code

P3C 5K7

Country

Canada

Facility Name

Local Institution

City

Sudbury

State/Province

Ontario

ZIP/Postal Code

P3E 2N8

Country

Canada

Facility Name

Local Institution

City

Toronto

State/Province

Ontario

ZIP/Postal Code

M4N 3M5

Country

Canada

Facility Name

Local Institution

City

Toronto

State/Province

Ontario

ZIP/Postal Code

M5B 1W8

Country

Canada

Facility Name

Local Institution

City

Weston

State/Province

Ontario

ZIP/Postal Code

M9N 1W4

Country

Canada

Facility Name

Local Institution

City

Greenfield Park

State/Province

Quebec

ZIP/Postal Code

J4V 2G8

Country

Canada

Facility Name

Local Institution

City

Montreal

State/Province

Quebec

ZIP/Postal Code

H1T 1C8

Country

Canada

Facility Name

Local Institution

City

Montreal

State/Province

Quebec

ZIP/Postal Code

H2K 4L5

Country

Canada

Facility Name

Local Institution

City

Montreal

State/Province

Quebec

ZIP/Postal Code

H2W 1T8

Country

Canada

Facility Name

Local Institution

City

Saint Georges Beauce

State/Province

Quebec

ZIP/Postal Code

G5Y 4W1

Country

Canada

Facility Name

Local Institution

City

St. Jerome

State/Province

Quebec

ZIP/Postal Code

J7Z 5T3

Country

Canada

Facility Name

Local Institution

City

St. Lambert

State/Province

Quebec

ZIP/Postal Code

J4P 2H4

Country

Canada

Facility Name

Local Institution

City

Terrebonne

State/Province

Quebec

ZIP/Postal Code

J6V 2H2

Country

Canada

Facility Name

Local Institution

City

Westmount

State/Province

Quebec

ZIP/Postal Code

H3Z 2M6

Country

Canada

Facility Name

Local Institution

City

Saskatoon

State/Province

Saskatchewan

ZIP/Postal Code

S7L OY7

Country

Canada

Facility Name

Local Institution

City

Quebec

ZIP/Postal Code

G1J 1Z6

Country

Canada

Facility Name

Local Institution

City

Temuco

State/Province

Araucania

ZIP/Postal Code

4781173

Country

Chile

Facility Name

Local Institution

City

Victoria

State/Province

Araucania

ZIP/Postal Code

4720000

Country

Chile

Facility Name

Local Institution

City

Osorno

State/Province

LOS Lagos

Country

Chile

Facility Name

Local Institution

City

Valdivia

State/Province

Los Rios

ZIP/Postal Code

5111847

Country

Chile

Facility Name

Local Institution

City

Santiago

State/Province

Metropolitana

ZIP/Postal Code

7500520

Country

Chile

Facility Name

Local Institution

City

Santiago

State/Province

Metropolitana

ZIP/Postal Code

7600448

Country

Chile

Facility Name

Local Institution

City

Santiago

State/Province

Metropolitana

ZIP/Postal Code

8330074

Country

Chile

Facility Name

Local Institution

City

Santiago

State/Province

Metropolitana

ZIP/Postal Code

8360160

Country

Chile

Facility Name

Local Institution

City

Santiago

State/Province

Metropolitana

ZIP/Postal Code

8900085

Country

Chile

Facility Name

Local Institution

City

Vina Del Mar

State/Province

Valparaiso

ZIP/Postal Code

2570017

Country

Chile

Facility Name

Local Institution

City

Beijing

State/Province

Beijing

ZIP/Postal Code

100020

Country

China

Facility Name

Local Institution

City

Beijing

State/Province

Beijing

ZIP/Postal Code

100029

Country

China

Facility Name

Local Institution

City

Beijing

State/Province

Beijing

ZIP/Postal Code

100037

Country

China

Facility Name

Local Institution

City

Beijing

State/Province

Beijing

ZIP/Postal Code

100038

Country

China

Facility Name

Local Institution

City

Beijing

State/Province

Beijing

ZIP/Postal Code

100088

Country

China

Facility Name

Local Institution

City

Beijing

State/Province

Beijing

ZIP/Postal Code

100853

Country

China

Facility Name

Local Institution

City

Guangzhou

State/Province

Guangdong

ZIP/Postal Code

510180

Country

China

Facility Name

Local Institution

City

Shijiazhuang

State/Province

Hebei

ZIP/Postal Code

050082

Country

China

Facility Name

Local Institution

City

Wuhan

State/Province

Hubei

ZIP/Postal Code

430060

Country

China

Facility Name

Local Institution

City

Suzhou

State/Province

Jiangsu

ZIP/Postal Code

215006

Country

China

Facility Name

Local Institution

City

Dalian

State/Province

Liaoning

ZIP/Postal Code

116033

Country

China

Facility Name

Local Institution

City

Shenyang

State/Province

Liaoning

ZIP/Postal Code

110001

Country

China

Facility Name

Local Institution

City

Qingdao

State/Province

Shandong

ZIP/Postal Code

266071

Country

China

Facility Name

Local Institution

City

Shanghai

State/Province

Shanghai

ZIP/Postal Code

200025

Country

China

Facility Name

Local Institution

City

Shanghai

State/Province

Shanghai

ZIP/Postal Code

200433

Country

China

Facility Name

Local Institution

City

Chengdu

State/Province

Sichuan

ZIP/Postal Code

610041

Country

China

Facility Name

Local Institution

City

Medellin

State/Province

Antioquia

Country

Colombia

Facility Name

Local Institution

City

Barranquilla

State/Province

Atlantico

Country

Colombia

Facility Name

Local Institution

City

Bucaramanga

State/Province

Santander

Country

Colombia

Facility Name

Local Institution

City

Cali

State/Province

Valle DEL Cauca

Country

Colombia

Facility Name

Local Institution

City

Bogota

Country

Colombia

Facility Name

Local Institution

City

Brno

ZIP/Postal Code

656 91

Country

Czechia

Facility Name

Local Institution

City

Havirov - Mesto

ZIP/Postal Code

736 01

Country

Czechia

Facility Name

Local Institution

City

Jindrichuv Hradec

ZIP/Postal Code

377 38

Country

Czechia

Facility Name

Local Institution

City

Kladno

ZIP/Postal Code

272 59

Country

Czechia

Facility Name

Local Institution

City

Kromeriz

ZIP/Postal Code

767 55

Country

Czechia

Facility Name

Local Institution

City

Mestec Kralove

ZIP/Postal Code

289 03

Country

Czechia

Facility Name

Local Institution

City

Ostrava

ZIP/Postal Code

702 00

Country

Czechia

Facility Name

Local Institution

City

Pisek

ZIP/Postal Code

397 01

Country

Czechia

Facility Name

Local Institution

City

Praha 1

ZIP/Postal Code

110 00

Country

Czechia

Facility Name

Local Institution

City

Praha 2

ZIP/Postal Code

128 08

Country

Czechia

Facility Name

Local Institution

City

Praha 5

ZIP/Postal Code

150 00

Country

Czechia

Facility Name

Local Institution

City

Prelouc

ZIP/Postal Code

535 01

Country

Czechia

Facility Name

Local Institution

City

Pribram

ZIP/Postal Code

261 26

Country

Czechia

Facility Name

Local Institution

City

Slany

ZIP/Postal Code

274 01

Country

Czechia

Facility Name

Local Institution

City

Usti Nad Orlici

ZIP/Postal Code

562 18

Country

Czechia

Facility Name

Local Institution

City

Arhus C

ZIP/Postal Code

8000

Country

Denmark

Facility Name

Local Institution

City

Esbjerg

ZIP/Postal Code

6700

Country

Denmark

Facility Name

Local Institution

City

Frederiksberg

ZIP/Postal Code

2000

Country

Denmark

Facility Name

Local Institution

City

Espoo

ZIP/Postal Code

02740

Country

Finland

Facility Name

Local Institution

City

Helsinki

ZIP/Postal Code

00029 HUS

Country

Finland

Facility Name

Local Institution

City

Jyvaskyla

ZIP/Postal Code

40100

Country

Finland

Facility Name

Local Institution

City

Kuopio

ZIP/Postal Code

FI-70100

Country

Finland

Facility Name

Local Institution

City

Tampere

ZIP/Postal Code

33900

Country

Finland

Facility Name

Local Institution

City

Abbeville Cedex

ZIP/Postal Code

80142

Country

France

Facility Name

Local Institution

City

Albi Cedex 09

ZIP/Postal Code

81013

Country

France

Facility Name

Local Institution

City

Cholet

ZIP/Postal Code

49325

Country

France

Facility Name

Local Institution

City

Grenoble Cedex 09

ZIP/Postal Code

38043

Country

France

Facility Name

Local Institution

City

Langres Cedex

ZIP/Postal Code

52206

Country

France

Facility Name

Local Institution

City

Paris Cedex 18

ZIP/Postal Code

75018

Country

France

Facility Name

Local Institution

City

Sisteron

ZIP/Postal Code

04203

Country

France

Facility Name

Local Institution

City

Toulon Cedex 09

ZIP/Postal Code

83041

Country

France

Facility Name

Local Institution

City

Berlin

ZIP/Postal Code

10117

Country

Germany

Facility Name

Local Institution

City

Berlin

ZIP/Postal Code

12099

Country

Germany

Facility Name

Local Institution

City

Berlin

ZIP/Postal Code

13353

Country

Germany

Facility Name

Local Institution

City

Bonn

ZIP/Postal Code

53115

Country

Germany

Facility Name

Local Institution

City

Essen

ZIP/Postal Code

45147

Country

Germany

Facility Name

Local Institution

City

Frankfurt Am Main

ZIP/Postal Code

60590

Country

Germany

Facility Name

Local Institution

City

Halle/saale

ZIP/Postal Code

06097

Country

Germany

Facility Name

Local Institution

City

Hamburg

ZIP/Postal Code

22291

Country

Germany

Facility Name

Local Institution

City

Hamburg

ZIP/Postal Code

22299

Country

Germany

Facility Name

Local Institution

City

Hamburg

ZIP/Postal Code

22527

Country

Germany

Facility Name

Local Institution

City

Heidelberg

ZIP/Postal Code

69115

Country

Germany

Facility Name

Local Institution

City

Heidelberg

ZIP/Postal Code

69120

Country

Germany

Facility Name

Local Institution

City

Kassel

ZIP/Postal Code

34121

Country

Germany

Facility Name

Local Institution

City

Koln

ZIP/Postal Code

51067

Country

Germany

Facility Name

Local Institution

City

Leipzig

ZIP/Postal Code

04104

Country

Germany

Facility Name

Local Institution

City

Magdeburg

ZIP/Postal Code

39112

Country

Germany

Facility Name

Local Institution

City

Mainz

ZIP/Postal Code

55116

Country

Germany

Facility Name

Local Institution

City

Mainz

ZIP/Postal Code

55131

Country

Germany

Facility Name

Local Institution

City

Mannheim

ZIP/Postal Code

68167

Country

Germany

Facility Name

Local Institution

City

Papenburg

ZIP/Postal Code

26871

Country

Germany

Facility Name

Local Institution

City

Regensburg

ZIP/Postal Code

93053

Country

Germany

Facility Name

Local Institution

City

Riesa

ZIP/Postal Code

01587

Country

Germany

Facility Name

Local Institution

City

Witten

ZIP/Postal Code

58455

Country

Germany

Facility Name

Local Institution

City

Wolmirstedt

ZIP/Postal Code

39326

Country

Germany

Facility Name

Local Institution

City

Athens

ZIP/Postal Code

151 23

Country

Greece

Facility Name

Local Institution

City

Larissa

ZIP/Postal Code

41 221

Country

Greece

Facility Name

Local Institution

City

Thiva

ZIP/Postal Code

32200

Country

Greece

Facility Name

Local Institution

City

Shatin

State/Province

NEW Territories

Country

Hong Kong

Facility Name

Local Institution

City

Chai Wan

Country

Hong Kong

Facility Name

Local Institution

City

Hong Kong

Country

Hong Kong

Facility Name

Local Institution

City

Hyderabad

State/Province

Andhra Pradesh

ZIP/Postal Code

500001

Country

India

Facility Name

Local Institution

City

Bangalore

State/Province

Karnataka

ZIP/Postal Code

560052

Country

India

Facility Name

Local Institution

City

Banglore

State/Province

Karnataka

ZIP/Postal Code

560054

Country

India

Facility Name

Local Institution

City

Mysore

State/Province

Karnataka

ZIP/Postal Code

570020

Country

India

Facility Name

Local Institution

City

Mumbai

State/Province

Maharashtra

ZIP/Postal Code

400007

Country

India

Facility Name

Local Institution

City

Mumbai

State/Province

Maharashtra

ZIP/Postal Code

400052

Country

India

Facility Name

Local Institution

City

Nagpur,

State/Province

Maharashtra

ZIP/Postal Code

440012

Country

India

Facility Name

Local Institution

City

Nashik

State/Province

Maharashtra

ZIP/Postal Code

422002

Country

India

Facility Name

Local Institution

City

Pune

State/Province

Maharashtra

ZIP/Postal Code

411001

Country

India

Facility Name

Local Institution

City

Dhantoli

State/Province

Nagpur

ZIP/Postal Code

440012

Country

India

Facility Name

Local Institution

City

Chennai

State/Province

Tamil Nadu

ZIP/Postal Code

600081

Country

India

Facility Name

Local Institution

City

Lucknow

State/Province

Uttar Pradesh

ZIP/Postal Code

226003

Country

India

Facility Name

Local Institution

City

Ahmedabad

ZIP/Postal Code

380060

Country

India

Facility Name

Local Institution

City

Bangalore

ZIP/Postal Code

560034

Country

India

Facility Name

Local Institution

City

Bikaner

ZIP/Postal Code

334 003

Country

India

Facility Name

Local Institution

City

Indore

ZIP/Postal Code

452001

Country

India

Facility Name

Local Institution

City

Jaipur

ZIP/Postal Code

302001

Country

India

Facility Name

Local Institution

City

Kottayam

ZIP/Postal Code

686016

Country

India

Facility Name

Local Institution

City

Pune

ZIP/Postal Code

411030

Country

India

Facility Name

Local Institution

City

Malang

State/Province

Jawa-timur

ZIP/Postal Code

65111

Country

Indonesia

Facility Name

Local Institution

City

Bandung

ZIP/Postal Code

40161

Country

Indonesia

Facility Name

Local Institution

City

Denpasar

ZIP/Postal Code

80114

Country

Indonesia

Facility Name

Local Institution

City

Jakarta Timur

ZIP/Postal Code

13750

Country

Indonesia

Facility Name

Local Institution

City

Jakarta

ZIP/Postal Code

10430

Country

Indonesia

Facility Name

Local Institution

City

Jakarta

ZIP/Postal Code

13310

Country

Indonesia

Facility Name

Local Institution

City

Padang

ZIP/Postal Code

25137

Country

Indonesia

Facility Name

Local Institution

City

Palembang

ZIP/Postal Code

30126

Country

Indonesia

Facility Name

Local Institution

City

Surabaya

ZIP/Postal Code

60286

Country

Indonesia

Facility Name

Local Institution

City

Yogyakarta

ZIP/Postal Code

55284

Country

Indonesia

Facility Name

Local Institution

City

Afula

ZIP/Postal Code

18101

Country

Israel

Facility Name

Local Institution

City

Ashkelon

ZIP/Postal Code

78278

Country

Israel

Facility Name

Local Institution

City

Givatayim

ZIP/Postal Code

53583

Country

Israel

Facility Name

Local Institution

City

Hadera

ZIP/Postal Code

38100

Country

Israel

Facility Name

Local Institution

City

Haifa

ZIP/Postal Code

31096

Country

Israel

Facility Name

Local Institution

City

Haifa

ZIP/Postal Code

34362

Country

Israel

Facility Name

Local Institution

City

Holon

ZIP/Postal Code

58100

Country

Israel

Facility Name

Local Institution

City

Nazareth

ZIP/Postal Code

16000

Country

Israel

Facility Name

Local Institution

City

Nazareth

ZIP/Postal Code

16100

Country

Israel

Facility Name

Local Institution

City

Petach-tikva

ZIP/Postal Code

49100

Country

Israel

Facility Name

Local Institution

City

Safed

ZIP/Postal Code

13100

Country

Israel

Facility Name

Local Institution

City

Tel Aviv

ZIP/Postal Code

64239

Country

Israel

Facility Name

Local Institution

City

Ascoli Piceno

ZIP/Postal Code

63100

Country

Italy

Facility Name

Local Institution

City

Chieti

ZIP/Postal Code

66013

Country

Italy

Facility Name

Local Institution

City

Genova

ZIP/Postal Code

16132

Country

Italy

Facility Name

Local Institution

City

Isernia

ZIP/Postal Code

86170

Country

Italy

Facility Name

Local Institution

City

Lido Di Camaiore

ZIP/Postal Code

55043

Country

Italy

Facility Name

Local Institution

City

Palermo

ZIP/Postal Code

90127

Country

Italy

Facility Name

Local Institution

City

Perugia

ZIP/Postal Code

06126

Country

Italy

Facility Name

Local Institution

City

San Daniele De Friuli (ud)

ZIP/Postal Code

33038

Country

Italy

Facility Name

Local Institution

City

Sassari

ZIP/Postal Code

07100

Country

Italy

Facility Name

Local Institution

City

Goyang-si

State/Province

Gyeonggi-do

ZIP/Postal Code

411-773

Country

Korea, Republic of

Facility Name

Local Institution

City

Seongnam-si

State/Province

Gyeonggi-do

ZIP/Postal Code

463-707

Country

Korea, Republic of

Facility Name

Local Institution

City

Kuri-city

State/Province

Kyunggi-do

ZIP/Postal Code

471-701

Country

Korea, Republic of

Facility Name

Local Institution

City

Busan

ZIP/Postal Code

602-702

Country

Korea, Republic of

Facility Name

Local Institution

City

Daegu

ZIP/Postal Code

700-721

Country

Korea, Republic of

Facility Name

Local Institution

City

Daejeon

ZIP/Postal Code

302-718

Country

Korea, Republic of

Facility Name

Local Institution

City

Gwangju

ZIP/Postal Code

501-757

Country

Korea, Republic of

Facility Name

Local Institution

City

Seoul

ZIP/Postal Code

110-744

Country

Korea, Republic of

Facility Name

Local Institution

City

Seoul

ZIP/Postal Code

130-709

Country

Korea, Republic of

Facility Name

Local Institution

City

Seoul

ZIP/Postal Code

143-729

Country

Korea, Republic of

Facility Name

Local Institution

City

Johor Bahru

State/Province

Johor

ZIP/Postal Code

80100

Country

Malaysia

Facility Name

Local Institution

City

Cheras

State/Province

Kuala Lumpur

ZIP/Postal Code

56000

Country

Malaysia

Facility Name

Local Institution

City

Pulau Pinang

State/Province

Pinang

ZIP/Postal Code

10990

Country

Malaysia

Facility Name

Local Institution

City

Kuching

State/Province

Sarawak

ZIP/Postal Code

93586

Country

Malaysia

Facility Name

Local Institution

City

Kuala Lumpur

ZIP/Postal Code

50586

Country

Malaysia

Facility Name

Local Institution

City

Kuala Lumpur

ZIP/Postal Code

59100

Country

Malaysia

Facility Name

Local Institution

City

Mexico

State/Province

Distrito Federal

ZIP/Postal Code

06726

Country

Mexico

Facility Name

Local Institution

City

Mexico

State/Province

Distrito Federal

ZIP/Postal Code

14080

Country

Mexico

Facility Name

Local Institution

City

Atizapan De Zaragoza

State/Province

Estado De Mexico

ZIP/Postal Code

52975

Country

Mexico

Facility Name

Local Institution

City

Acapulco

State/Province

Guerrero

ZIP/Postal Code

39570

Country

Mexico

Facility Name

Local Institution

City

Guadalajara

State/Province

Jalisco

ZIP/Postal Code

44600

Country

Mexico

Facility Name

Local Institution

City

Guadalajara

State/Province

Jalisco

ZIP/Postal Code

44670

Country

Mexico

Facility Name

Local Institution

City

Zapopan

State/Province

Jalisco

ZIP/Postal Code

45200

Country

Mexico

Facility Name

Local Institution

City

Monterrey

State/Province

Nuevo Leon

ZIP/Postal Code

64240

Country

Mexico

Facility Name

Local Institution

City

San Luis Potosi, Slp

State/Province

San Luis Potosi

ZIP/Postal Code

78240

Country

Mexico

Facility Name

Local Institution

City

Culiacan

State/Province

Sinaloa

ZIP/Postal Code

80020

Country

Mexico

Facility Name

Local Institution

City

Hermosillo

State/Province

Sonora

ZIP/Postal Code

83190

Country

Mexico

Facility Name

Local Institution

City

Jalapa

State/Province

Veracruz

ZIP/Postal Code

91020

Country

Mexico

Facility Name

Local Institution

City

Aguascalientes

ZIP/Postal Code

20127

Country

Mexico

Facility Name

Local Institution

City

Aguascalientes

ZIP/Postal Code

20230

Country

Mexico

Facility Name

Local Institution

City

Chihuahua

ZIP/Postal Code

31203

Country

Mexico

Facility Name

Local Institution

City

Durango

ZIP/Postal Code

34080

Country

Mexico

Facility Name

Local Institution

City

Queretaro

ZIP/Postal Code

76000

Country

Mexico

Facility Name

Local Institution

City

San Luis Potosi

ZIP/Postal Code

78200

Country

Mexico

Facility Name

Local Institution

City

Fyllingsdal

ZIP/Postal Code

5145

Country

Norway

Facility Name

Local Institution

City

Kongsberg

ZIP/Postal Code

3602

Country

Norway

Facility Name

Local Institution

City

Oslo

ZIP/Postal Code

0264

Country

Norway

Facility Name

Local Institution

City

Oslo

ZIP/Postal Code

0450

Country

Norway

Facility Name

Local Institution

City

Naga City

State/Province

Camarines SUR

ZIP/Postal Code

4400

Country

Philippines

Facility Name

Local Institution

City

Binan

State/Province

Laguna

ZIP/Postal Code

4024

Country

Philippines

Facility Name

Local Institution

City

Iligan City

State/Province

Lanao DEL Norte

ZIP/Postal Code

9200

Country

Philippines

Facility Name

Local Institution

City

Cagayan De Oro City

ZIP/Postal Code

9000

Country

Philippines

Facility Name

Local Institution

City

Cavite

ZIP/Postal Code

4114

Country

Philippines

Facility Name

Local Institution

City

Laoag City

ZIP/Postal Code

2900

Country

Philippines

Facility Name

Local Institution

City

Manila

ZIP/Postal Code

1000

Country

Philippines

Facility Name

Local Institution

City

Muntinlupa City

ZIP/Postal Code

1780

Country

Philippines

Facility Name

Local Institution

City

Czestochowa

ZIP/Postal Code

42-200

Country

Poland

Facility Name

Local Institution

City

Elblag

ZIP/Postal Code

82-300

Country

Poland

Facility Name

Local Institution

City

Gdynia

ZIP/Postal Code

81-423

Country

Poland

Facility Name

Local Institution

City

Gliwice

ZIP/Postal Code

44-100

Country

Poland

Facility Name

Local Institution

City

Gniewkowo

ZIP/Postal Code

88-140

Country

Poland

Facility Name

Local Institution

City

Grodzisk Mazowiecki

ZIP/Postal Code

05-825

Country

Poland

Facility Name

Local Institution

City

Inowroclaw

ZIP/Postal Code

88-100

Country

Poland

Facility Name

Local Institution

City

Kielce

ZIP/Postal Code

25-736

Country

Poland

Facility Name

Local Institution

City

Krakow

ZIP/Postal Code

30-092

Country

Poland

Facility Name

Local Institution

City

Krakow

ZIP/Postal Code

31-501

Country

Poland

Facility Name

Local Institution

City

Lodz

ZIP/Postal Code

91-302

Country

Poland

Facility Name

Local Institution

City

Piotrkow Trybunalski

ZIP/Postal Code

97-300

Country

Poland

Facility Name

Local Institution

City

Plock

ZIP/Postal Code

09-402

Country

Poland

Facility Name

Local Institution

City

Poznan

ZIP/Postal Code

60-539

Country

Poland

Facility Name

Local Institution

City

Pulawy

ZIP/Postal Code

24-100

Country

Poland

Facility Name

Local Institution

City

Siemianowice Slaskie

ZIP/Postal Code

41-100

Country

Poland

Facility Name

Local Institution

City

Skierniewice

ZIP/Postal Code

96-100

Country

Poland

Facility Name

Local Institution

City

Tarnow

ZIP/Postal Code

33-100

Country

Poland

Facility Name

Local Institution

City

Warsaw

ZIP/Postal Code

00-217

Country

Poland

Facility Name

Local Institution

City

Warszawa

ZIP/Postal Code

03-242

Country

Poland

Facility Name

Local Institution

City

Warszawa

ZIP/Postal Code

04-073

Country

Poland

Facility Name

Local Institution

City

Wegrow

ZIP/Postal Code

07-100

Country

Poland

Facility Name

Local Institution

City

Zabrze

ZIP/Postal Code

41-800

Country

Poland

Facility Name

Local Institution

City

Zarow

ZIP/Postal Code

58-130

Country

Poland

Facility Name

Local Institution

City

Kaluga

State/Province

Anenki

ZIP/Postal Code

248007

Country

Russian Federation

Facility Name

Local Institution

City

Barnaul

ZIP/Postal Code

656055

Country

Russian Federation

Facility Name

Local Institution

City

Chelyabinsk

ZIP/Postal Code

454136

Country

Russian Federation

Facility Name

Local Institution

City

Ekaterinburg

ZIP/Postal Code

620109

Country

Russian Federation

Facility Name

Local Institution

City

Ekaterinburg

ZIP/Postal Code

620144

Country

Russian Federation

Facility Name

Local Institution

City

Kazan

ZIP/Postal Code

420012

Country

Russian Federation

Facility Name

Local Institution

City

Kemerovo

ZIP/Postal Code

650002

Country

Russian Federation

Facility Name

Local Institution

City

Krasnodar

ZIP/Postal Code

350042

Country

Russian Federation

Facility Name

Local Institution

City

Moscow

ZIP/Postal Code

101990

Country

Russian Federation

Facility Name

Local Institution

City

Moscow

ZIP/Postal Code

105066

Country

Russian Federation

Facility Name

Local Institution

City

Moscow

ZIP/Postal Code

109240

Country

Russian Federation

Facility Name

Local Institution

City

Moscow

ZIP/Postal Code

111539

Country

Russian Federation

Facility Name

Local Institution

City

Moscow

ZIP/Postal Code

117485

Country

Russian Federation

Facility Name

Local Institution

City

Moscow

ZIP/Postal Code

119121

Country

Russian Federation

Facility Name

Local Institution

City

Moscow

ZIP/Postal Code

121356

Country

Russian Federation

Facility Name

Local Institution

City

Moscow

ZIP/Postal Code

121552

Country

Russian Federation

Facility Name

Local Institution

City

Moscow

ZIP/Postal Code

125284

Country

Russian Federation

Facility Name

Local Institution

City

Moscow

ZIP/Postal Code

125367

Country

Russian Federation

Facility Name

Local Institution

City

Moscow

ZIP/Postal Code

127644

Country

Russian Federation

Facility Name

Local Institution

City

Moscow

ZIP/Postal Code

129301

Country

Russian Federation

Facility Name

Local Institution

City

Moscow

ZIP/Postal Code

129336

Country

Russian Federation

Facility Name

Local Institution

City

Moscow

ZIP/Postal Code

143000

Country

Russian Federation

Facility Name

Local Institution

City

Nizhniy Novgorod

ZIP/Postal Code

603035

Country

Russian Federation

Facility Name

Local Institution

City

Novosibirsk

ZIP/Postal Code

630047

Country

Russian Federation

Facility Name

Local Institution

City

Perm

ZIP/Postal Code

614097

Country

Russian Federation

Facility Name

Local Institution

City

Perm

ZIP/Postal Code

614107

Country

Russian Federation

Facility Name

Local Institution

City

Ryazan

ZIP/Postal Code

390026

Country

Russian Federation

Facility Name

Local Institution

City

Saint Petersburg

ZIP/Postal Code

193079

Country

Russian Federation

Facility Name

Local Institution

City

Saint-petersburg

ZIP/Postal Code

190000

Country

Russian Federation

Facility Name

Local Institution

City

Saint-petersburg

ZIP/Postal Code

191025

Country

Russian Federation

Facility Name

Local Institution

City

Saint-petersburg

ZIP/Postal Code

193144

Country

Russian Federation

Facility Name

Local Institution

City

Saint-petersburg

ZIP/Postal Code

194156

Country

Russian Federation

Facility Name

Local Institution

City

Saint-petersburg

ZIP/Postal Code

194291

Country

Russian Federation

Facility Name

Local Institution

City

Samara

ZIP/Postal Code

443070

Country

Russian Federation

Facility Name

Local Institution

City

Samara

ZIP/Postal Code

443095

Country

Russian Federation

Facility Name

Local Institution

City

Saratov

ZIP/Postal Code

410028

Country

Russian Federation

Facility Name

Local Institution

City

Saratov

ZIP/Postal Code

410054

Country

Russian Federation

Facility Name

Local Institution

City

St.petersburg

ZIP/Postal Code

195112

Country

Russian Federation

Facility Name

Local Institution

City

St.petersburg

ZIP/Postal Code

197198

Country

Russian Federation

Facility Name

Local Institution

City

Tomsk

ZIP/Postal Code

634012

Country

Russian Federation

Facility Name

Local Institution

City

Tumen

ZIP/Postal Code

625023

Country

Russian Federation

Facility Name

Local Institution

City

Tver

ZIP/Postal Code

170036

Country

Russian Federation

Facility Name

Local Institution

City

Yaroslavl

ZIP/Postal Code

150062

Country

Russian Federation

Facility Name

Local Institution

City

Singapore

ZIP/Postal Code

169609

Country

Singapore

Facility Name

Local Institution

City

Singapore

ZIP/Postal Code

308433

Country

Singapore

Facility Name

Local Institution

City

Singapore

ZIP/Postal Code

529889

Country

Singapore

Facility Name

Local Institution

City

Singapore

ZIP/Postal Code

768828

Country

Singapore

Facility Name

Local Institution

City

Bloemfontein

State/Province

FREE State

ZIP/Postal Code

9300

Country

South Africa

Facility Name

Local Institution

City

Bloemfontein

State/Province

FREE State

ZIP/Postal Code

9301

Country

South Africa

Facility Name

Local Institution

City

Alberton

State/Province

Gauteng

ZIP/Postal Code

1450

Country

South Africa

Facility Name

Local Institution

City

Bellville, Cape Town

State/Province

Western CAPE

ZIP/Postal Code

7530

Country

South Africa

Facility Name

Local Institution

City

Cape Town

State/Province

Western CAPE

ZIP/Postal Code

7925

Country

South Africa

Facility Name

Local Institution

City

Somerset West

State/Province

Western CAPE

ZIP/Postal Code

7130

Country

South Africa

Facility Name

Local Institution

City

Worcester

State/Province

Western CAPE

ZIP/Postal Code

6850

Country

South Africa

Facility Name

Local Institution

City

Pretoria

ZIP/Postal Code

0041

Country

South Africa

Facility Name

Local Institution

City

Torrevieja

State/Province

Alicante

ZIP/Postal Code

03186

Country

Spain

Facility Name

Local Institution

City

Hospitalet De Llobregat

State/Province

Barcelona

ZIP/Postal Code

08907

Country

Spain

Facility Name

Local Institution

City

Lugo

State/Province

Galicia

ZIP/Postal Code

27003

Country

Spain

Facility Name

Local Institution

City

Albacete

ZIP/Postal Code

02006

Country

Spain

Facility Name

Local Institution

City

Madrid

ZIP/Postal Code

28007

Country

Spain

Facility Name

Local Institution

City

Madrid

ZIP/Postal Code

28034

Country

Spain

Facility Name

Local Institution

City

Valencia

ZIP/Postal Code

46017

Country

Spain

Facility Name

Local Institution

City

Goteborg

ZIP/Postal Code

416 85

Country

Sweden

Facility Name

Local Institution

City

Goteborg

ZIP/Postal Code

417 17

Country

Sweden

Facility Name

Local Institution

City

Molndal

ZIP/Postal Code

431 80

Country

Sweden

Facility Name

Local Institution

City

Stockholm

ZIP/Postal Code

111 57

Country

Sweden

Facility Name

Local Institution

City

Stockholm

ZIP/Postal Code

118 83

Country

Sweden

Facility Name

Local Institution

City

Stockholm

ZIP/Postal Code

141 86

Country

Sweden

Facility Name

Local Institution

City

Uppsala

ZIP/Postal Code

751 85

Country

Sweden

Facility Name

Local Institution

City

Kaohsiung

ZIP/Postal Code

807

Country

Taiwan

Facility Name

Local Institution

City

Taichung

ZIP/Postal Code

402

Country

Taiwan

Facility Name

Local Institution

City

Tainan

ZIP/Postal Code

704

Country

Taiwan

Facility Name

Local Institution

City

Taipei

ZIP/Postal Code

10507

Country

Taiwan

Facility Name

Local Institution

City

Taipei

ZIP/Postal Code

111

Country

Taiwan

Facility Name

Local Institution

City

Taipei

ZIP/Postal Code

220

Country

Taiwan

Facility Name

Local Institution

City

Isparta

ZIP/Postal Code

32100

Country

Turkey

Facility Name

Local Institution

City

Istanbul

ZIP/Postal Code

34304

Country

Turkey

Facility Name

Local Institution

City

Istanbul

ZIP/Postal Code

34390

Country

Turkey

Facility Name

Local Institution

City

Kirikkale

ZIP/Postal Code

71100

Country

Turkey

Facility Name

Local Institution

City

Dnipropetrovsk

ZIP/Postal Code

49005

Country

Ukraine

Facility Name

Local Institution

City

Donetsk

ZIP/Postal Code

83114

Country

Ukraine

Facility Name

Local Institution

City

Kharkiv

ZIP/Postal Code

61002

Country

Ukraine

Facility Name

Local Institution

City

Kharkiv

ZIP/Postal Code

61018

Country

Ukraine

Facility Name

Local Institution

City

Kharkiv

ZIP/Postal Code

61029

Country

Ukraine

Facility Name

Local Institution

City

Kharkiv

ZIP/Postal Code

61115

Country

Ukraine

Facility Name

Local Institution

City

Kharkiv

ZIP/Postal Code

61176

Country

Ukraine

Facility Name

Local Institution

City

Kyiv

ZIP/Postal Code

01023

Country

Ukraine

Facility Name

Local Institution

City

Kyiv

ZIP/Postal Code

02091

Country

Ukraine

Facility Name

Local Institution

City

Kyiv

ZIP/Postal Code

02660

Country

Ukraine

Facility Name

Local Institution

City

Kyiv

ZIP/Postal Code

03680

Country

Ukraine

Facility Name

Local Institution

City

Kyiv

ZIP/Postal Code

04107

Country

Ukraine

Facility Name

Local Institution

City

Kyiv

ZIP/Postal Code

04114

Country

Ukraine

Facility Name

Local Institution

City

Aberdeen

State/Province

Aberdeenshire

ZIP/Postal Code

AB25 2ZN

Country

United Kingdom

Facility Name

Local Institution

City

Chesterfield

State/Province

Derbyshire

ZIP/Postal Code

S44 5BL

Country

United Kingdom

Facility Name

Local Institution

City

Basildon

State/Province

Essex

ZIP/Postal Code

SS16 5NL

Country

United Kingdom

Facility Name

Local Institution

City

Romford

State/Province

Essex

ZIP/Postal Code

RM7 0AG

Country

United Kingdom

Facility Name

Local Institution

City

Kirkcaldy

State/Province

Fife

ZIP/Postal Code

KY2 5AH

Country

United Kingdom

Facility Name

Local Institution

City

London

State/Province

Greater London

ZIP/Postal Code

SW17 ORE

Country

United Kingdom

Facility Name

Local Institution

City

Glasgow

State/Province

Lanarkshire

ZIP/Postal Code

G11 6NT

Country

United Kingdom

Facility Name

Local Institution

City

Glasgow

State/Province

Lanarkshire

ZIP/Postal Code

G51 4TF

Country

United Kingdom

Facility Name

Local Institution

City

Blackpool

State/Province

Lancashire

ZIP/Postal Code

FY3 8NR

Country

United Kingdom

Facility Name

Local Institution

City

Northampton

State/Province

Northamptonshire

ZIP/Postal Code

NN1 5BD

Country

United Kingdom

Facility Name

Local Institution

City

Worksop

State/Province

Nottinghamshire

ZIP/Postal Code

S18 0BD

Country

United Kingdom

Facility Name

Local Institution

City

Craigavon

State/Province

Portadown

ZIP/Postal Code

BT63 5QQ

Country

United Kingdom

Facility Name

Local Institution

City

Paisley

State/Province

Renfrewshire

ZIP/Postal Code

PA2 9PN

Country

United Kingdom

Facility Name

Local Institution

City

Barnsley

State/Province

South Yorkshire

ZIP/Postal Code

S75 2EP

Country

United Kingdom

Facility Name

Local Institution

City

Larbert

State/Province

Stirlingshire

ZIP/Postal Code

FK5 4WR

Country

United Kingdom

Facility Name

Local Institution

City

Newcastle Upon

State/Province

Tyne And Wear

ZIP/Postal Code

NE2 4HH

Country

United Kingdom

Facility Name

Local Institution

City

Birmingham

State/Province

West Midlands

ZIP/Postal Code

B18 7QH

Country

United Kingdom

Facility Name

Local Institution

City

Chichester

State/Province

West Sussex

ZIP/Postal Code

PO19 6SE

Country

United Kingdom

12. IPD Sharing Statement

Citations:

PubMed Identifier

35570249

Citation

Jamieson MJ, Byon W, Dettloff RW, Crawford M, Gargalovic PS, Merali SJ, Onorato J, Quintero AJ, Russ C. Apixaban Use in Obese Patients: A Review of the Pharmacokinetic, Interventional, and Observational Study Data. Am J Cardiovasc Drugs. 2022 Nov;22(6):615-631. doi: 10.1007/s40256-022-00524-x. Epub 2022 May 16.

Results Reference

derived

PubMed Identifier

35224730

Citation

Natale P, Palmer SC, Saglimbene VM, Ruospo M, Razavian M, Craig JC, Jardine MJ, Webster AC, Strippoli GF. Antiplatelet agents for chronic kidney disease. Cochrane Database Syst Rev. 2022 Feb 28;2(2):CD008834. doi: 10.1002/14651858.CD008834.pub4.

Results Reference

derived

PubMed Identifier

31249919

Citation

Bhagirath VC, Eikelboom JW, Hirsh J, Coppens M, Ginsberg J, Vanassche T, Yuan F, Chan N, Yusuf S, Connolly SJ. Apixaban-Calibrated Anti-FXa Activity in Relation to Outcome Events and Clinical Characteristics in Patients with Atrial Fibrillation: Results from the AVERROES Trial. TH Open. 2017 Dec 12;1(2):e139-e145. doi: 10.1055/s-0037-1613679. eCollection 2017 Jul.

Results Reference

derived

PubMed Identifier

26590293

Citation

Ng KH, Shestakovska O, Connolly SJ, Eikelboom JW, Avezum A, Diaz R, Lanas F, Yusuf S, Hart RG. Efficacy and safety of apixaban compared with aspirin in the elderly: a subgroup analysis from the AVERROES trial. Age Ageing. 2016 Jan;45(1):77-83. doi: 10.1093/ageing/afv156. Epub 2015 Nov 19.

Results Reference

derived

PubMed Identifier

23892201

Citation

Hohnloser SH, Shestakovska O, Eikelboom J, Franzosi MG, Tan RS, Zhu J, Yusuf S, Connolly SJ. The effects of apixaban on hospitalizations in patients with different types of atrial fibrillation: insights from the AVERROES trial. Eur Heart J. 2013 Sep;34(35):2752-9. doi: 10.1093/eurheartj/eht292. Epub 2013 Jul 25.

Results Reference

derived

PubMed Identifier

23390125

Citation

Lip GY, Connolly S, Yusuf S, Shestakovska O, Flaker G, Hart R, Lanas F, Xavier D, Eikelboom J; ERROES Investigators. Modification of outcomes with aspirin or apixaban in relation to CHADS(2) and CHA(2)DS(2)-VASc scores in patients with atrial fibrillation: a secondary analysis of the AVERROES study. Circ Arrhythm Electrophysiol. 2013 Feb;6(1):31-8. doi: 10.1161/CIRCEP.112.975847. Epub 2013 Feb 6.

Results Reference

derived

PubMed Identifier

23033347

Citation

Flaker GC, Eikelboom JW, Shestakovska O, Connolly SJ, Kaatz S, Budaj A, Husted S, Yusuf S, Lip GY, Hart RG. Bleeding during treatment with aspirin versus apixaban in patients with atrial fibrillation unsuitable for warfarin: the apixaban versus acetylsalicylic acid to prevent stroke in atrial fibrillation patients who have failed or are unsuitable for vitamin K antagonist treatment (AVERROES) trial. Stroke. 2012 Dec;43(12):3291-7. doi: 10.1161/STROKEAHA.112.664144. Epub 2012 Oct 2.

Results Reference

derived

PubMed Identifier

22305462

Citation

Diener HC, Eikelboom J, Connolly SJ, Joyner CD, Hart RG, Lip GY, O'Donnell M, Hohnloser SH, Hankey GJ, Shestakovska O, Yusuf S; AVERROES Steering Committee and Investigators. Apixaban versus aspirin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a predefined subgroup analysis from AVERROES, a randomised trial. Lancet Neurol. 2012 Mar;11(3):225-31. doi: 10.1016/S1474-4422(12)70017-0. Epub 2012 Feb 1.

Results Reference

derived

PubMed Identifier

21309657

Citation

Connolly SJ, Eikelboom J, Joyner C, Diener HC, Hart R, Golitsyn S, Flaker G, Avezum A, Hohnloser SH, Diaz R, Talajic M, Zhu J, Pais P, Budaj A, Parkhomenko A, Jansky P, Commerford P, Tan RS, Sim KH, Lewis BS, Van Mieghem W, Lip GY, Kim JH, Lanas-Zanetti F, Gonzalez-Hermosillo A, Dans AL, Munawar M, O'Donnell M, Lawrence J, Lewis G, Afzal R, Yusuf S; AVERROES Steering Committee and Investigators. Apixaban in patients with atrial fibrillation. N Engl J Med. 2011 Mar 3;364(9):806-17. doi: 10.1056/NEJMoa1007432. Epub 2011 Feb 10.

Results Reference

derived

Links:

URL

http://bms.com/studyconnect/Pages/home.aspx

Description

BMS Clinical Trial Patient Recruiting

Learn more about this trial

A Phase III Study of Apixaban in Patients With Atrial Fibrillation

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A Phase III Study of Apixaban in Patients With Atrial Fibrillation (AVERROES)

Atrial Fibrillation

About this trial

Eligibility Criteria

Sites / Locations

Arms of the Study

Arm 1

Arm 2

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

1. Study Identification

2. Study Status

3. Sponsor/Collaborators

4. Oversight

5. Study Description

6. Conditions and Keywords

7. Study Design

8. Arms, Groups, and Interventions

10. Eligibility

12. IPD Sharing Statement

Learn more about this trial