Study of Dietary Phosphate and Mineral Homeostasis in Early Chronic Kidney Disease
Kidney Diseases
About this trial
This is an interventional treatment trial for Kidney Diseases focused on measuring Chronic Kidney Disease, CKD, Diet, Dietary Phosphate, Mineral Metabolism, FGF-23
Eligibility Criteria
Inclusion Criteria:
- CKD patients with CKD stage 3 and 4 (eGFR < 60 ml/min and > 15 ml/min per 1.73 m2, not requiring dialysis).
- Normal serum phosphate stable over three months (> 0.87 mmol/L and < 1.70 mmol/L)
- Not yet following a low phosphate diet as reported by the patient or the renal dietitian (<1500mg/d)
- Over 19 years of age
Exclusion Criteria:
- Body mass index <20 kg/m2
- Current use of phosphate binders or active vitamin D or phenytonin (which induces vitamin D catabolism)
- Primary parathyroid defects
- Diagnosed osteoporosis
- Gut absorption defects
- Liver disease
- Pregnancy or lactation
- Patients hospitalised within the last 4 weeks
Sites / Locations
- St. Paul's Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
Active Comparator
1
2
3
High/ Low Phosphate diet I. A five-day low phosphate diet / A five-day low phosphate diet with the addition of a phosphate binder / A five-day high phosphate diet. II. A five-day low phosphate diet / A five-day high phosphate diet / A five-day low phosphate diet with the addition of a phosphate binder III. A five-day high phosphate diet / A five-day low phosphate diet with the addition of a phosphate binder / A five-day low phosphate diet. IV. A five-day high phosphate diet / A five-day low phosphate diet / A five-day low phosphate diet with the addition of a phosphate binder. V. A five-day low phosphate diet with the addition of a phosphate binder / A five-day low phosphate diet / A five-day high phosphate diet. VI. A five-day low phosphate diet with the addition of a phosphate binder / A five-day high phosphate diet / A five-day low phosphate diet.
High/ Low Phosphate diet
High/ Low Phosphate diet