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Effects of Monosodium Glutamate on Energy Balance and Eating Behavior

Primary Purpose

Obesity, Weight Gain, Food Preferences

Status
Completed
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
Broth
Broth
Sponsored by
USDA, Western Human Nutrition Research Center
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional basic science trial for Obesity focused on measuring Obesity, Food preferences, Eating Behavior

Eligibility Criteria

19 Years - 50 Years (Adult)FemaleAccepts Healthy Volunteers

Inclusion Criteria:

  • Women
  • Age 19-45
  • BMI 27-35
  • Blood pressure <140/90
  • Non-smoking

Exclusion Criteria:

  • Anemic: hgb < 11.5 mg/dL
  • Sensitivity to MSG (self reported)
  • Pregnant or planning to get pregnant
  • Taking medication for hypertension, depression, or weight loss
  • Diabetic
  • Vegetarian
  • MRI Contraindications: internal metal, braces on teeth, history of metal in the eye, claustrophobia
  • blindness or heavily corrected vision
  • not fluent in English

Sites / Locations

  • Western Human Nutrition Center, University of California Davis

Arms of the Study

Arm 1

Arm 2

Arm Type

Placebo Comparator

Active Comparator

Arm Label

Broth- NaCl

Broth- MSG

Arm Description

Sodium chloride containing broth matched for sodium content to the MSG broth

MSG containing broth with the same sodium content as the placebo comparator.

Outcomes

Primary Outcome Measures

Change in body weight
Subjects will have their body weight measured to determine the effect of MSG on body weight regain following weight loss.

Secondary Outcome Measures

Change in body fat
Volunteers will have their body fat measured by DEXA (Dual X-ray Absorptiometry) to determine the effect of MSG on body fat regain following weight loss.
Change in eating behavior
The effect of MSG on eating behavior will be measured using questionnaires, sensory evaluation testing, stress responsivity, and liking and wanting tests, and appetite assessments.
Change in resting energy expenditure
The effect of MSG on resting energy expenditure will be measured using respiratory gas exchange using a metabolic cart system.

Full Information

First Posted
August 3, 2011
Last Updated
May 19, 2015
Sponsor
USDA, Western Human Nutrition Research Center
Collaborators
Ajinomoto USA, INC.
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1. Study Identification

Unique Protocol Identification Number
NCT01410838
Brief Title
Effects of Monosodium Glutamate on Energy Balance and Eating Behavior
Official Title
Effects of Ingesting Monosodium Glutamate (MSG) on Energy Balance and Eating Behavior Following Moderate Energy Restriction and Weight Loss in Overweight Women
Study Type
Interventional

2. Study Status

Record Verification Date
August 2014
Overall Recruitment Status
Completed
Study Start Date
August 2011 (undefined)
Primary Completion Date
August 2014 (Actual)
Study Completion Date
August 2014 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
USDA, Western Human Nutrition Research Center
Collaborators
Ajinomoto USA, INC.

4. Oversight

Data Monitoring Committee
No

5. Study Description

Brief Summary
This study will test whether regular consumption of Monosodium Glutamate (MSG) immediately prior to each of the three major meals (breakfast, lunch, dinner) inhibits body weight and fat regain following a period of moderate, yet clinically significant weight loss.
Detailed Description
The proposed study enables us to assess the long term effects of consuming MSG on body weight regain following weight loss.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Obesity, Weight Gain, Food Preferences
Keywords
Obesity, Food preferences, Eating Behavior

7. Study Design

Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
ParticipantInvestigator
Allocation
Randomized
Enrollment
44 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Broth- NaCl
Arm Type
Placebo Comparator
Arm Description
Sodium chloride containing broth matched for sodium content to the MSG broth
Arm Title
Broth- MSG
Arm Type
Active Comparator
Arm Description
MSG containing broth with the same sodium content as the placebo comparator.
Intervention Type
Other
Intervention Name(s)
Broth
Intervention Description
200 mL of sodium chloride containing broth, consumed three times per day
Intervention Type
Other
Intervention Name(s)
Broth
Intervention Description
200 mL of MSG containing broth consumed three times per day
Primary Outcome Measure Information:
Title
Change in body weight
Description
Subjects will have their body weight measured to determine the effect of MSG on body weight regain following weight loss.
Time Frame
weeks 11, 12, and 25
Secondary Outcome Measure Information:
Title
Change in body fat
Description
Volunteers will have their body fat measured by DEXA (Dual X-ray Absorptiometry) to determine the effect of MSG on body fat regain following weight loss.
Time Frame
weeks 11 and 25
Title
Change in eating behavior
Description
The effect of MSG on eating behavior will be measured using questionnaires, sensory evaluation testing, stress responsivity, and liking and wanting tests, and appetite assessments.
Time Frame
weeks 11, 12 and 25
Title
Change in resting energy expenditure
Description
The effect of MSG on resting energy expenditure will be measured using respiratory gas exchange using a metabolic cart system.
Time Frame
weeks 11, 12, and 25

10. Eligibility

Sex
Female
Minimum Age & Unit of Time
19 Years
Maximum Age & Unit of Time
50 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: Women Age 19-45 BMI 27-35 Blood pressure <140/90 Non-smoking Exclusion Criteria: Anemic: hgb < 11.5 mg/dL Sensitivity to MSG (self reported) Pregnant or planning to get pregnant Taking medication for hypertension, depression, or weight loss Diabetic Vegetarian MRI Contraindications: internal metal, braces on teeth, history of metal in the eye, claustrophobia blindness or heavily corrected vision not fluent in English
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Kevin Laugero, PhD
Organizational Affiliation
WHNRC, ARS, University of California Davis
Official's Role
Principal Investigator
Facility Information:
Facility Name
Western Human Nutrition Center, University of California Davis
City
Davis
State/Province
California
ZIP/Postal Code
95616
Country
United States

12. IPD Sharing Statement

Links:
URL
http://www.ars.usda.gov/Main/docs.htm?docid=11240
Description
USDA Western Human Nutrition Research Center

Learn more about this trial

Effects of Monosodium Glutamate on Energy Balance and Eating Behavior

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