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Effects of Exercise-intensity on Physiological Adaptations in Overweight and Obese (TRENO)

Primary Purpose

Overweight, Obesity

Status
Completed
Phase
Not Applicable
Locations
Norway
Study Type
Interventional
Intervention
Long distanse moderate training
Long interval training
Short interval training
Sponsored by
Norwegian University of Science and Technology
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Overweight focused on measuring Exercise, High-intensity, Interval training

Eligibility Criteria

18 Years - 70 Years (Adult, Older Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

  • BMI > 25

Exclusion Criteria:

  • Exclusion criteria will be cardiovascular disease or another disease that is not consistent with high physical activity. Subjects should not have exercised regularly before the study.

Sites / Locations

  • Medical Faculty, Norwegian University of Science and Technology

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

Experimental

Experimental

Arm Label

Long distanse moderate training

Long interval training

Short interval training

Arm Description

40 minutes moderate treadmill running

4x4min interval treadmill running

10x1min interval treadmill running

Outcomes

Primary Outcome Measures

Maximal oxygen uptake
Change in maximal oxygen uptake will be measured after six weeks of various exercise training and related to changes in blood volume, cardiac function, endothelial function and mitochondrial function.

Secondary Outcome Measures

Full Information

First Posted
October 10, 2011
Last Updated
August 1, 2016
Sponsor
Norwegian University of Science and Technology
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1. Study Identification

Unique Protocol Identification Number
NCT01453972
Brief Title
Effects of Exercise-intensity on Physiological Adaptations in Overweight and Obese
Acronym
TRENO
Official Title
Effects of Exercise-intensity on Physiological Adaptations in Overweight and Obese
Study Type
Interventional

2. Study Status

Record Verification Date
August 2016
Overall Recruitment Status
Completed
Study Start Date
October 2011 (undefined)
Primary Completion Date
February 2012 (Actual)
Study Completion Date
December 2012 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Norwegian University of Science and Technology

4. Oversight

Data Monitoring Committee
No

5. Study Description

Brief Summary
The main purpose of our study is to examine the physiological adaptations in oxygen transport chain for high-intensity exercise and moderate exercise in overweight and obese humans. The main goals are: To investigate the most effective short-and long-interval training in terms of VO2max, pulmonary diffusion, cardiac output, endothelial function and mitochondrial function. How these physiological adaptations affect the aerobic endurance and performance, and how this training can reduce the risk of cardiovascular diseases related to overweight and obesity.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Overweight, Obesity
Keywords
Exercise, High-intensity, Interval training

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
Outcomes Assessor
Allocation
Randomized
Enrollment
30 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Long distanse moderate training
Arm Type
Experimental
Arm Description
40 minutes moderate treadmill running
Arm Title
Long interval training
Arm Type
Experimental
Arm Description
4x4min interval treadmill running
Arm Title
Short interval training
Arm Type
Experimental
Arm Description
10x1min interval treadmill running
Intervention Type
Behavioral
Intervention Name(s)
Long distanse moderate training
Intervention Description
Moderate exercise
Intervention Type
Behavioral
Intervention Name(s)
Long interval training
Intervention Description
High-intensity exercise, long duration
Intervention Type
Behavioral
Intervention Name(s)
Short interval training
Intervention Description
High intensity exercise, short duration
Primary Outcome Measure Information:
Title
Maximal oxygen uptake
Description
Change in maximal oxygen uptake will be measured after six weeks of various exercise training and related to changes in blood volume, cardiac function, endothelial function and mitochondrial function.
Time Frame
6 weeks

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
70 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: BMI > 25 Exclusion Criteria: Exclusion criteria will be cardiovascular disease or another disease that is not consistent with high physical activity. Subjects should not have exercised regularly before the study.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Øivind Rognmo, PhD
Organizational Affiliation
Norwegian University of Science and Technology
Official's Role
Principal Investigator
Facility Information:
Facility Name
Medical Faculty, Norwegian University of Science and Technology
City
Trondheim
State/Province
Sør-Trøndelag
ZIP/Postal Code
7491
Country
Norway

12. IPD Sharing Statement

Citations:
PubMed Identifier
26440134
Citation
Baekkerud FH, Solberg F, Leinan IM, Wisloff U, Karlsen T, Rognmo O. Comparison of Three Popular Exercise Modalities on V O2max in Overweight and Obese. Med Sci Sports Exerc. 2016 Mar;48(3):491-8. doi: 10.1249/MSS.0000000000000777.
Results Reference
result

Learn more about this trial

Effects of Exercise-intensity on Physiological Adaptations in Overweight and Obese

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