Recording for Potential AF Drivers and Patient Specific Atrial Anatomy & Atrial Electrogram Maps (CONFIRM)

This is an interventional diagnostic trial for Atrial Fibrillation focused on measuring atrial fibrillation, cardiac ablation Read More

Inclusion Criteria:

• Patients at VCU Medical Center who are 21 years or older undergoing EPS for ablation of persistent AF (non-rheumatic) whose AF episodes last equal to or greater than 7 days but terminate with DC cardioversion or anti-arrhythmic drugs and do not recur within 24 hours.
• Per current standard of care, AF patients must have failed equal to or greater than 1 anti-arrhythmic drug to qualify for ablation.

Exclusion Criteria:

• Active coronary ischemic in the past year
• Rheumatic valve disease, that leads to distinct AF and increases thromboembolic risk
• Prior ablation or cardiac surgery, that alters atrial electophysiology
• Left atrial clot or dense contrast on TEE, which would increase thromboembolic risk
• Out of range serum electrolytes, including K outside 4.0-5.0 mmol/1
• Left atrial diameter greater than 60 mm, to exclude extreme structural remodeling and failure to maintain sinus rhythm
• Thrombotic disease, venous filters, transient ischemic attack or cerebrovascular accident, to minimize additional risk
• Pregnancy
• Inability or unwillingness to provide informed consent
• Unable to converse in English
• Use of anti-arrhythmic drug less than 5 X half-life Prior ablation or cardiac surgery, that alters atrial electophysiology