Stair Descending vs. Stair Ascending Exercise
Primary Purpose
Aging, Heart Failure, Sarcopenia
Status
Completed
Phase
Not Applicable
Locations
Cyprus
Study Type
Interventional
Intervention
Exercise
Sponsored by
About this trial
This is an interventional prevention trial for Aging focused on measuring Eccentric exercise, Aging, Heart failure, Muscle strength loss, Sarcopenia
Eligibility Criteria
Inclusion Criteria:
- chronic heart failure (New York Heart Association class I-II)
- subject provides written informed consent
- personal physician of the participants provides written informed consent
Exclusion Criteria:
- smoker
- consumed any nutritional supplement the last 3 months
- performed intense eccentric exercise the last 6 months
- non Caucasian
Sites / Locations
- European University Cyprus
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Experimental
Arm Label
Stair descending group
Stair ascending group
Arm Description
Stair descending exercise. Participants will carry out six weeks of stair descending training consisting of three exercise sessions per week.
Stair ascending exercise. Participants will carry out six weeks of stair descending training consisting of three exercise sessions per week.
Outcomes
Primary Outcome Measures
Muscle strength (torque)
An isokinetic dynamometer (Cybex, Ronkonkoma, NY) will be used for the measurement of isometric, eccentric and concentric knee extensor peak torque at 90° knee flexion. The average of the three best maximal voluntary contractions with their dominant leg will be recorded. In order to ensure that the subjects provide their maximal effort, the measurements will be repeated if the difference between the lower and the higher torque value exceeded 10%. There will be two minutes rest between isometric efforts.
Secondary Outcome Measures
Pain free range of motion (degrees)
The assessment of pain-free ROM will be performed manually using the the isokinetic dynamometer. The investigator will move the calf at a very low angular velocity from 0 knee extension to the position where the subject will feel any discomfort.
Creatine kinase, CK (activity IU)
CK activity will be measured as a general indicator of muscle damage.It will be measured in a Cobas Integra Plus 400 chemistry analyzer.
Delayed onset muscle soreness, DOMS (scale 1-10)
Each participant will assess delayed onset muscle soreness (DOMS) during squat movement (90o knee flexion) and perceived soreness will be rated on a scale ranging from 1 (normal) to 10 (very sore).
Full Information
NCT ID
NCT01673958
First Posted
August 22, 2012
Last Updated
August 24, 2012
Sponsor
European University Cyprus
Collaborators
University of Thessaly, Aristotle University Of Thessaloniki
1. Study Identification
Unique Protocol Identification Number
NCT01673958
Brief Title
Stair Descending vs. Stair Ascending Exercise
Official Title
The Effect of Stair Descending and Stair Ascending Exercise on Muscle Strength and Performance: the SmartEscalator Device
Study Type
Interventional
2. Study Status
Record Verification Date
August 2012
Overall Recruitment Status
Completed
Study Start Date
February 2012 (undefined)
Primary Completion Date
April 2012 (Actual)
Study Completion Date
April 2012 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
European University Cyprus
Collaborators
University of Thessaly, Aristotle University Of Thessaloniki
4. Oversight
Data Monitoring Committee
No
5. Study Description
Brief Summary
The aim of the present project is to compare the acute and chronic effect of stair descending versus stair ascending exercise on muscle damage and performance in elderly males with chronic heart failure.
Detailed Description
Study design:
Twelve elderly males with chronic heart failure, New York Heart Association class I-II, will participate in this study. Participants will be allocated into two equally-sized groups: a stair descending group (n = 6) and a stair ascending group (n = 6). At the beginning of the study, the volunteers will perform an acute bout of stair descending or stair ascending exercise on an automatic escalator (4 sets of 3 min each, speed will be set at 45 steps∙min-1). Step height will be 20.5 mm. Before and at day 2 post exercise, physiologic measurements will be performed and blood samples will be collected. Then, participants will carry out six weeks of stair descending or ascending training consisting of three exercise sessions per week (the first two weeks the speed will be set at 45 steps∙min-1, the next two weeks at 50 steps∙min-1 and the last two weeks at 55 steps∙min-1 for both groups). Afterward, they will repeat the acute stair descending or ascending protocol, as carried out at the beginning of the study, and the same physiologic measurements will be performed and blood samples will be collected.
Measurements:
Isometric (at 90 knee flexion), concentric and eccentric peak torque at 60o∙s-1of quadriceps femoris, pain-free range of motion, delayed onset muscle soreness and creatine kinase will be measured.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Aging, Heart Failure, Sarcopenia
Keywords
Eccentric exercise, Aging, Heart failure, Muscle strength loss, Sarcopenia
7. Study Design
Primary Purpose
Prevention
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
12 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Stair descending group
Arm Type
Experimental
Arm Description
Stair descending exercise. Participants will carry out six weeks of stair descending training consisting of three exercise sessions per week.
Arm Title
Stair ascending group
Arm Type
Experimental
Arm Description
Stair ascending exercise. Participants will carry out six weeks of stair descending training consisting of three exercise sessions per week.
Intervention Type
Other
Intervention Name(s)
Exercise
Intervention Description
Comparison between stair descending and stair ascending training
Primary Outcome Measure Information:
Title
Muscle strength (torque)
Description
An isokinetic dynamometer (Cybex, Ronkonkoma, NY) will be used for the measurement of isometric, eccentric and concentric knee extensor peak torque at 90° knee flexion. The average of the three best maximal voluntary contractions with their dominant leg will be recorded. In order to ensure that the subjects provide their maximal effort, the measurements will be repeated if the difference between the lower and the higher torque value exceeded 10%. There will be two minutes rest between isometric efforts.
Time Frame
Change from baseline in muscle strength at day 2 post exercise at the first and sixth week of training
Secondary Outcome Measure Information:
Title
Pain free range of motion (degrees)
Description
The assessment of pain-free ROM will be performed manually using the the isokinetic dynamometer. The investigator will move the calf at a very low angular velocity from 0 knee extension to the position where the subject will feel any discomfort.
Time Frame
Before and at day 2 post exercise at the first and sixth week of training
Title
Creatine kinase, CK (activity IU)
Description
CK activity will be measured as a general indicator of muscle damage.It will be measured in a Cobas Integra Plus 400 chemistry analyzer.
Time Frame
Before and at day 2 post exercise at the first and sixth week of training
Title
Delayed onset muscle soreness, DOMS (scale 1-10)
Description
Each participant will assess delayed onset muscle soreness (DOMS) during squat movement (90o knee flexion) and perceived soreness will be rated on a scale ranging from 1 (normal) to 10 (very sore).
Time Frame
Before and at day 2 post exercise at the first and sixth week of training
10. Eligibility
Sex
Male
Minimum Age & Unit of Time
60 Years
Maximum Age & Unit of Time
70 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
chronic heart failure (New York Heart Association class I-II)
subject provides written informed consent
personal physician of the participants provides written informed consent
Exclusion Criteria:
smoker
consumed any nutritional supplement the last 3 months
performed intense eccentric exercise the last 6 months
non Caucasian
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
George Panayiotou, PhD
Organizational Affiliation
Research Centre, European University Cyprus
Official's Role
Study Chair
Facility Information:
Facility Name
European University Cyprus
City
Nicosia
ZIP/Postal Code
1516
Country
Cyprus
12. IPD Sharing Statement
Citations:
PubMed Identifier
20508540
Citation
Paschalis V, Nikolaidis MG, Theodorou AA, Panayiotou G, Fatouros IG, Koutedakis Y, Jamurtas AZ. A weekly bout of eccentric exercise is sufficient to induce health-promoting effects. Med Sci Sports Exerc. 2011 Jan;43(1):64-73. doi: 10.1249/MSS.0b013e3181e91d90.
Results Reference
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Stair Descending vs. Stair Ascending Exercise
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