Freezing of Gait in Parkinson's Disease (FOG)
Parkinson Disease
About this trial
This is an interventional treatment trial for Parkinson Disease
Eligibility Criteria
Inclusion Criteria:
- Age: greater than 18 years old and without an upper age limit
- diagnosis of idiopathic PD exhibiting at least 2 or 3 cardinal signs (bradykinesia, rigidity, and resting tremor)
- Ambulate independently without an assistive device for at least 60 meters
- Freezing of gait episodes confirmed through the FOG-Q and evaluation by a fellowship trained Movement Disorder neurologist
- Willingness and ability to participate in training and complete training diary
- Documented FOG-Q and Unified Parkinson's Disease Rating Scale (UPDRS) II
- Ability to sign informed consent
- Pregnant females will be included in the study and there are no known risks to the pregnant female or fetus
Exclusion Criteria:
- Inability to complete questionnaires
- Unwillingness to participate in training, complete all questionnaires and training diary
- Subjects with secondary causes of parkinsonism
- Significant dementia (MOCA <20)
- Prior deep brain stimulation (DBS) surgery or pallidotomy
- Subjects cannot participate in any form of Physical Therapy, Occupational Therapy or Speech Therapy during the study period
- Subjects cannot start any new medications during the study period.
Sites / Locations
- Duke University Medical Center
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
Training Group
Non Training Group
There are 2 study visits. Subjects in this group will complete the following: Visit 1 Gait evaluation Neuropsychological testing Questionnaires and assessments Taught how to complete a visual problem-solving task (Tower of Hanoi) Given a diary to record training at home. In-home •For 6 weeks at home, complete the in-home visual problem-solving tasks as instructed at Visit 1 Visit 2 Gait evaluation Neuropsychological testing Questionnaires and assessments
There are 2 study visits. Subjects in this group will complete the following: Visit 1 Gait evaluation Neuropsychological testing Questionnaires and assessments Visit 2 Gait evaluation Neuropsychological testing Questionnaires and assessments