Deep Brain Stimulation Effects on Weight Change and Metabolic Rate
Obesity
About this trial
This is an interventional treatment trial for Obesity focused on measuring Obesity, Deep Brain Stimulation, LHA
Eligibility Criteria
Inclusion Criteria:
- Prior placement of LHA DBS in accordance with previous study protocol
Exclusion Criteria:
- Not a participant of the original LHA DBS study
- Prior brain surgery, excluding the placement of LHA DBS
- Taking medications with a recognized adverse event of weight change.
- Diagnosis of a neurological disorder, such as multiple sclerosis or stroke.
- Concurrent use of weight-loss prescription drug therapy or the use of over- the-counter weight loss preparations.
- Unable to participate in scheduled study visits
Sites / Locations
- Allegheny Health Network
Arms of the Study
Arm 1
Experimental
DBS of the Lateral Hypothalamic Area
Single Arm: Deep Brain Stimulation of LHA for maximum RMR On days 1-4, subjects stayed in the inpatient unit to have metabolic weight, temperature, and resting metabolic rate (RMR) measured at different settings. Metabolic testing RMR measurement: A clear plastic hood was placed over the head and chest Oxygen intake and carbon dioxide out-put were measured to determine how many calories were burned during the next 15-30 minutes. Each hour for the next seven hours, DBS settings were changed and the above process was repeated. On Day 4, a DXA scan was performed to assess body composition. Primary endpoint is the determination of optimal settings