Back to resultsA Study to Evaluate the Effect of Long-term Treatment With BELVIQ (Lorcaserin HCl) on the Incidence of Major Adverse Cardiovascular Events and Conversion to Type 2 Diabetes Mellitus in Obese and Overweight Subjects With Cardiovascular Disease or Multiple Cardiovascular Risk Factors (CAMELLIA-TIMI)
Primary Purpose
Cardiovascular Disease, High Cardiovascular Risk, Obesity
Status
Completed
Phase
Phase 4
Locations
International
Study Type
Interventional
Intervention
Lorcaserin hydrochloride
Placebo
Sponsored by
About this trial
This is an interventional treatment trial for Cardiovascular Disease focused on measuring Diabetes, Cardiovascular Disease, Multiple Cardiovascular Risk Factors, Obesity, Overweight, MACE, Conversion to Diabetes
Eligibility Criteria
Inclusion Criteria
- BMI greater than or equal (>=) to 27 kilogram per meter square (kg/m^2)
- Subjects able and willing to comply with a reduced-calorie diet and an increased physical activity program
Age >= to 40 years with established CV disease as defined by one of the following:
- History of documented MI or ischemic stroke
- History of peripheral artery disease
- History of revascularization (coronary, carotid, or peripheral artery)
- Significant unrevascularized coronary arterial stenosis
OR
Age >= to 55 years for women or >= to 50 years for men who have type 2 diabetes mellitus (T2DM) without established CV disease plus at least one of the following CV risk factors:
- Hypertension, or currently receiving therapy for documented hypertension
- Dyslipidemia, or currently taking prescription lipid-lowering therapy for documented dyslipidemia
- Estimated glomerular filtration rate >= to 30 to less than equal (<=) to 60 mililitre per minute per 1.73 meter square (mL/min/1.73 m^) per the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation
- High high sensitivity C-reactive protein (hsCRP)
- Urinary albumin-to-creatinine ratio (ACR) >= 30 ug/mg
Subjects with T2DM may have a pre-existing or new diagnosis of T2DM. A new diagnosis of T2DM (ie, discovered at Screening) should be based on the 2013 American Diabetes Association (ADA) guidelines.
All T2DM subjects must have an HbA[1c] less (<) than 10% at Screening. If subjects are being treated, or upon diagnosis need to be treated with antidiabetic agents, the T2DM treatment regimen must be stable for at least 3 months prior to randomization.
Exclusion Criteria
- Moderate or greater symptoms of congestive cardiac failure (New York Heart Association [NYHA] class III or IV)
- Known left ventricular (LV) ejection fraction < than 20%
- Moderate or greater symptoms of pulmonary hypertension (PH)
- Known severe valvular disease
- Moderate renal impairment, severe renal impairment (estimated glomerular filtration rate < 30 mL/min/1.73 m^ per the CKD-EPI equation based on ideal body weight), or end stage renal disease (ESRD)
- Severe hepatic impairment
- Use of other products intended for weight loss including prescription drugs, over-the-counter (OTC) drugs, and herbal preparations
- Use of more than one other serotonergic drug
- Use of drugs known to increase the risk for cardiac valvulopathy within 6 months prior to Screening including, but not limited to: pergolide, ergotamine, methysergide, cabergoline
- History or evidence of clinically significant disease (e.g., malignancy, cardiac, respiratory, gastrointestinal, renal or psychiatric disease)
- Use of lorcaserin HCl prior to Screening or hypersensitivity to lorcaserin HCl or any of the excipients
- Planned bariatric surgery
- Females must not be breastfeeding or pregnant
Sites / Locations
- Advanced Cardiovascular, LLC
- North Alabama Research Center, LLC
- UAB Medical Center
- Coastal Clinical Research, Inc.
- Mobile Heart Specialists, PC
- Alaska Heart Institute
- Connect Clinical Research Center, LCC
- Arrowhead Health Centers
- Phoenix Heart, PLLC
- Eclipse Clinical Research
- NEA Baptist Clinic
- Arkansas Cardiology Clinic
- Central Arkansas Veterans Healthcare System
- Preferred Research Partners
- Clinical Research Alliance
- Central Cardiology
- Cardiovascular Research Foundation of Southern Cal
- Capitol Interventional Cardiology
- San Diego Costal Endocrinology Group AMC
- John Muir Physician Network Clinical Research Cent
- Medical Group of Encino
- Marin Endocrine Care & Research, Inc.
- California Heart Specialists
- Del Rosario Medical Clinic, Inc.
- Diabetes and Endocrine Associates
- La Mesa Cardiac Center
- Alliance Research Centers
- Torrance Clinical Research Institute, Inc.
- Long Beach Center for Clinical Research
- Metabolic Clinic and Research Center
- Beverly Hills Cardiology
- VA Greater Los Angeles Health Care System
- Clinical Interventions Research Institute
- Brigid Freyne MD Inc
- Valley Clinical Trials Inc
- Carr Cardiology
- Northern California Clinical Research Center
- Sharp Rees-Stealy Medical Group, Inc.
- University of California San Diego
- Ritchken and First MD's
- West Coast Research LLC
- Coastal Multi-Specialty Research
- Westlake Medical Research
- Harbor - UCLA Medical Center
- Ronald Chochinov, MD
- Ventura Cardiology Consultants
- Infosphere Clinical Research
- UCH-MHS Cardiac Research
- Creekside Endocrine Associates PC
- New West Physicians, PC
- University of Colorado Health
- Connecticut Clinical Research, LLC
- Bridgeport Hospital
- Clinical Research Works, Bristol
- Cardiology Associates of Fairfield County, Norwalk
- Cardiology Associates of Fairfield County, P.C.
- Stamford Therapeutics Consortium
- Cardiology Associates of Fairfield County, P.C.
- Connecticut Heart and Vascular Center
- Chase Medical Research, LLC
- Red Clay Research
- Alfieri Cardiology
- Aventura Heart Center
- Zasa Clinical Research
- Meridien Research
- NOVA Southeastern University
- Bay Area Cardiology
- Meridien Research, Brooksville
- Clearwater Cardiovascular and Interventional Cons.
- Clinical Research of South Florida
- Holy Cross Medical Group
- Cardiology Research Associates
- International Medical Research
- Asclepius Medical Research
- Fleming Island Center for Clinical Research
- Integrative Research Associates, Inc.
- M & O Clinical Research, LLC
- Primary Care Associates
- Florida Research Network, LLC
- George E. Platt, M.D.
- Eastern Research, Inc.
- Larry K. Levinson, D.O., P.A.
- Research Physicians Network Alliance
- Pasco Cardiology Center
- Nature Coast Clinical Research
- University of Florida- Jacksonville
- Jacksonville Center for Clinical Research
- Westside Center for Clinical Research
- Meridien Research
- Pharmax Research Clinic, Inc
- Life Spring Research Foundation
- United Clinical Research Corp.
- Cardiovascular Research Center of South Florida
- South Florida Research Group LLC
- South Florida Research Solutions
- Southwest Florida Research
- Ocala Research Institute, Inc
- Oviedo Medical Research
- Cardiology Partners Clinical Research Institute
- Palm Beach Gardens Research Center
- Research Physicians Network Alliance, Pembrok
- South Florida Research Solutions
- Cardiology Consultants
- Clinical Research of Central Florida
- Columbia Primary Care, LLC d/b/a Heart and Health Institute
- St Johns Center for Clinical Research
- Charlotte Heart Group Research Center
- Progressive Medical Research
- Brevard Cardiovascular Research Associates Inc
- Clearwater Cardiovascular and Interventional Cons.
- Bayfront Health St. Petersburg, Research
- Meridien Research - St. Petersburg
- Professional Health Care of Pinellas, INC
- Intercoastal Medical Group
- Springfield Medical Center
- Advanced Clinical Research Group
- Meridien Research - Tampa
- Stedman Clinical Trials
- Healthpoint Medical Group, Inc
- Interventional Cardiac Consultants
- Lovelace Scientific Research
- Indian River Medical Center-Cardiology
- Cardiology Partners Clinical Research Institute
- Cleveland Clinic Foundation
- Metabolic Research Institute
- Clinical Research of Central Florida
- Atlanta Diabetes Associates, Endocrinology
- Rockdale Medical-Research Associates
- Atlanta Heart Specialists
- Urban Family Practice Associates/Clinical Research Advantage
- Endocrine Research Solutions, Inc.
- Herman Clinical Research LLC
- Atlanta Heart Specialists
- Northwest Heart Clinical Research, LLC
- Cedar-Crosse Research Center
- Northwestern University Feinberg School of Medicine
- University of Chicago
- Consultants in Cardiovascular Medicine
- Clinical Investigation Specialists, Inc. in Gurnee
- Advanced CardioVascular Consultants, SC
- Community Clinical Research Center
- American Health Network of IN, LLC, Avon
- Premier Healthcare, LLC
- Deaconess Clinic, Inc.
- American Health Network of IN, LLC, Franklin
- American Health Network of IN, LLC, Greenfield
- American Health Network - Thomas Moretto, MD
- Medical Consultants PC
- American Health Network of IN, LLC
- Cardiology Associates of Northwest Indiana, P.C
- The University of Iowa, College of Public Health
- Professional Research Network of Kansas, LLC
- Norton Heart Specialists
- Norton Heart Specialists
- L-MARC Research Center
- Research Integrity LLC
- Central Maine Medical Center
- Acadia Clinical Research, LLC
- Eastern Maine Medical Center Northeast Cardiology Associates
- Southern Maine Health Care/Maine Medical Center Research Ins
- InterMed, PA
- Medstar Cardiology Associates
- Chesapeake Cardiovascular Associates, GBMC
- Clinical Research, Inc
- Medstar Union Memorial Heart Specialists
- Medstar Union Memorial Hospital
- Spectrum Clinical Research
- Overlea Personal Physicians
- Shahid Saeed MD, PC
- Maryland Heart Associates, LLC
- Klein & Associates, MD, PA
- MedStar Health Research Institute
- Lutherville Personal Physicians
- MD Medical Research
- Endocrine & Metabolic Consultants
- Lutherville Personal Physicians
- Overlea Personal Physicians
- Tufts Medical Center
- MGH Weight Center
- Brigham and Women's Hospital
- New England Center for Clinical Research, IMCA
- Pentucket Medical Associates
- ActivMed Practices
- Partners Community Physicians Organization
- Partners Community Physicians Organization
- Endeavor Medical Research PLC
- Cadillac Clinical Research, LLC
- Westside Family Medical Center, PC
- Cardiology Consultants of East Michigan
- Marquette General Heart and Vascular Institute
- MidMichigan Medical Center
- Nisus Research at McLaren Northern Michigan Hospital
- Saint Joseph Mercy Oakland Hospital
- Remedica LLC
- Michigan CardioVascular Institute
- American Center for Clinical Trials
- Medical Research Associates, Inc.
- Michigan Heart
- Minneapolis Heart Institute Foundation
- Essentia Institute of Rural Health
- MNCOME Clinic
- Radiant Research, Inc.
- Minneapolis Heart Institute
- Regions Hospital
- Coast Cardiovascular Consultants PLLC
- Cardiology Associates Research, LLC
- Diabetes & Endocrinology Specialists, Inc.
- BodyAesthetic Research Center
- Billings Clinic Research Center
- Montana Health Research Institute, Inc.
- Glacier View Cardiology PC
- Internal Medical Associates of Grand Island, PC
- Clinical Research Advantage / Rita Chuang, M.D.
- Clinical Research Advantage, Inc.
- Clinical Research of South Nevada
- Medicor Cardiology, PA
- Advanced Heart Care
- UmiMed Center LLC
- Cardiovascular Associates of the Delaware Valley
- Advocare Heights Primary Care
- Cardiovascular Associates of the Delaware Valley P
- NJ Heart
- Rutgers New Jersey Medical School
- Cardiovascular Associates Delaware Valley Sewell
- Cardio Metabolic Institute
- New Mexico Heart Institute, PA
- Albany College of Medicine, Division of Endocrinology
- Capital Cardiology Associates
- United Medical Associates, PC
- James J. Peters VA Medical Center, Bronx, NY
- Buffalo Heart Group
- Regional Clinical Research, Inc.
- Long Island Gastrointestinal Research Group LLP
- Long Island Heart Associates
- North Shore Diabetes and Endocrine Associates
- Weill Cornell Medical College
- DiGiovanna Institute for Medical Education
- Hudson Valley Heart Center
- Rochester Clinical Research, Inc.
- Northwell Health Physician Partners Cardiology
- Capital Cardiology Associates
- Great Lakes Medical Research
- Kernodle Clinic
- Clinical Trials of America Inc.
- Metrolina Internal Medicine
- PMG Research of Charlotte, LLC
- Bland Clinic, PA
- Clinical Trials of America Inc. Hickory
- Clinical Trials of America, Inc.
- Peters Medical Research
- Clinical Trials of America, Inc.
- Diabetes & Endocrinology Consultants
- Burke Primary Care
- Pinehurst Medical Clinic, Inc.
- Wake Research Associates, LLC
- PMG Research of Rocky Mount
- PMG Research of Salisbury
- Sanford Cardiology
- Piedmont Healthcare
- PMG Research of Wilmington
- PMG Research of Winston-Salem, LLC
- Lillestol Research LLC
- Aultman Hospital
- The Lindner Research Center
- Sentral Clinical Research
- Delaware Research Group, LLC
- Awasty Research Network, LLC
- Community Health Care
- Apex Medical Research Inc.
- Integris Cardiovascular Physicians LLC
- Memorial Clinical Research
- South Oklahoma Heart Research, LLC
- Oklahoma Heart Institute
- Vital Prospects Clinical Research Institute PC
- Blair Medical Associates
- Clinical Research Associates of Central PA, LLC
- Capital Area Research, LLC
- Geisinger Health Clinic
- Geisinger Health System
- Doylestown Health Cardiology a Division of Doylestown Health
- Altoona Center for Clinical Research
- Liberty Family Practice
- Endocrine Clinical Research LLC
- Joseph Lamantia, DO
- The Clinical Trial Center, LLC
- Lycoming Internal Medicine, Inc.
- Berkley Hills Clinicals
- Ilumina Clinical Associates, Johnstown
- Joseph Lamantia, DO
- Comprehensive Cardiology Consultants
- Detweiler Family Medicine and Associates PC
- Green & Seidner Family Practice Associates
- Capital Area Research LLC
- Endocrine Metabolic Associates
- Pottstown Medical Specialists, Inc. (PMSI)
- Geisinger Clinic
- Partners in Clinical Research
- Radiant Research, Inc.
- Mountain View Clinical Research
- Palmetto Research Center, LLC
- Brown Clinic, PLLP
- PMG Research of Bristol, LLC
- Chattanooga Research and Medicine (CHARM)
- WR-ClinSearch, LLC
- Wellmont CVA Heart Institute
- Research Associates of Jackson
- Kore Cardiovascular Research
- The Jackson Clinic, PA
- Wellmont CVA Heart Institute
- Holston Medical Group
- Wellmont CVA Heart Institute
- The Endocrine Clinic
- Cardiology Wellness Center
- Central Texas Clinical Research, LLC
- Texas Diabetes & Endocrinology
- Texas Health Physicians Group
- Adriana Pop-Moody MD Clinic, PA
- Baylor Research Institute
- Texas Health Physicians Group
- Texas Health Physicians Group, Dallas
- Research Institute of Dallas
- Odilon Alvarado, M.D.
- Texas Health Physicians Group Fort Worth
- Tand R Clinic, PA
- San Gabriel Clinical Research, LLC
- Angiocardiac Care of Texas PA
- Oxford Clinical Research, LLC
- West Houston Area Clinical Trial Consultants, LLC
- Endocrine and Psychiatry Center
- Texas Health Physicians Group
- Texas Cardiology Associates of Houston
- Jalil Aziz Khan M.D., P.A.
- Midland Clinical Research Center
- Permian Research Foundation
- Medical Clinic of North Texas
- Clinical Investigations of Texas, LLC
- Texas Diabetes
- Physician PrimeCare Research Institute, PLLC
- Cardiology Clinic of San Antonio
- Radiant Research San Antonio
- Martin Diagnostic Clinic
- Cardiovascular Associates of East Texas
- Bay Area Total Health Medical Group
- Advanced Research Institute
- Jean Brown Research
- Alexandria Clinical Research, LLC
- Washington Center for Weight Management and Resear
- Burke Internal Medicine and Research
- Cardiology Consultants of Danville, Inc.
- Danville Internal Medicine, Inc
- Virginia Heart
- Seven Corners Medical Research Center
- INOVA Health Care Services
- Burke Internal Medicine and Research
- Manassas Clinical Research Center
- Health Research of Hampton Roads - Norfolk, Inc.
- Clinical Research Associates of Tidewater
- Clinical Research Partners
- Virginia Cardiovascular Specialists
- National Clinical Research-Richmond, Inc
- Selma Medical Associates
- Larry D. Stonesifer, MD, Inc PS
- Seattle Women's
- Rowan Research Inc.
- MultiCare Research Institute
- Universal Research Group
- Wenatchee Valley Hospital & Clinics
- Cardiology Associates of Bellin Health
- Prevea Clinic, Inc
- Clinical Investigation Specialists, Inc.
- Meriter hospital Inc., DBA: UnityPoint Health-Meriter Heart
- Marshfield Clinic
- Aspirus Research Institute
- Coffs Harbour Health Campus
- Gosford Hospital, Cardiology Clinical Trials
- Liverpool Hospital
- Illawarra Shoalhaven Local Health District, Clinical Trial and Research Unit
- Wollongong Hospital
- Core Research Group
- Princess Alexandra Hospital, Cardiology Research Department
- Royal Brisbane and Women's Hospital, Endocrinology Department
- HeartCare Partners Clinical Research Unit
- AusTrials Pty Ltd
- Gold Coast Hospital, Cardiovascular Research Centre
- New Royal Adelaide Hospital, Cardiology Department
- Adelaide Medical Research
- Lyell McEwin Hospital, Department of Cardiology
- Heart and Vascular Institute
- The Queen Elizabeth Hospital
- Ballarat Health Services
- Geelong Cardiology Research Unit, Barwon Health
- Austin Health - Heidelberg Repatriation Hospital, Department of Medicine, Boronia Centre
- Avenue Cardiovascular Centre
- Joondalup Cardiovascular Trials Foundation Inc
- Fiona Stanley Hospital, Cardiology Research Department,CDO11
- South Australian Medical Research Inst, Centre for Clinical Research
- The Partners Clinical Research Centre
- LMC Clinical Research Inc. (Calgary)
- Gordon and Leslie Diamond Health Care Centre
- Nova Scotia Health Authority /QEII Health Sciences Centre
- LMC Diabetes & Endocrinology - Brampton
- McMaster University
- JBN Medical Diagnostic Services Inc.
- Aviva Clinical Trial Group In.
- Cambridge Cardiac Care Centre
- Joanne F. Liutkus Medicine Professional Corp.
- Saul Vizel Professional Medicine Corporation, Vizel Cardiac Research
- LMC Diabetes & Endocrinology (Etobicoke)
- Wharton Medical Clinic Clinical Trials Group Inc.
- Saint Josephs Health Care London
- LMC Diabetes & Endocrinoly
- New Market Cardiology Research Group
- Dr. Michael Heffernan
- LMC Clinical Research Inc. (Oakville)
- Dr. Cha
- University of Ottawa Heart Institute
- Kawartha Cardiology Clinical Trials
- Dr. Dinkar Shukla Professional Medicine Corporation
- Dr Roger Labonte Professional Medicine Corp
- LMC Diabetes & Endocrinology (Thornhill)
- JJ DIG Research Ltd.
- Keele Medical Place
- LMC Clinical Research Inc. (Bayview)
- St Michael's Hospital Health Centre
- ViaCar Recherche Clinique
- Q&T Research Outaouais Inc.
- ViaCar Recherche Clinique Inc.
- Manna Research Inc
- Clinique Sante Cardio MC
- Universitaire de Cardiologie et de Pneumologie de Quebec
- Centre hospitalier régional de Lanaudière
- Recherche Clinique London
- CardioVasc HR, Inc.
- ViaCar Recherche Clinique Inc.
- LMC Clinical Research Inc. (Montreal)
- Biomedica Research Group
- Sociedad Medica Cardiologica El Llano
- Hospital Regional Concepcion
- Cardiocob
- Servicios Medicos Godoy Ltda.
- Ccbr Cecim
- Centro Investigacion Clinica del Sur
- CECMI Ltda.
- ICLE
- Private Medical Practice
- IMED Clin Trials
- Cardiolink ClinTrials S.C.
- Centro de Estudios Clinicos y Especialidades Medicas S.C.
- Hospital de Angeles Xalapa
- Fundacion Cardiovascular de Aguascalientes
- Hospital Cardiologica Aguascalientes
- Mentrials S.A.de C.V.
- North Shore Hospital-Cardiology Research
- Middlemore Hospital
- North Shore Hospital - Diabetes Clinic
- Christchurch Hospital, Lipids
- Christchurch Hospital, Cardiology Research
- Dunedin Hospital
- Taranaki Base Hospital
- Hutt Hospital, Cardiology Dept
- Auckland City Hospital
- Hawkes Bay Regional Hospital
- Nelson Hospital, Cardiology Department
- Lakeland Clinical Trials, Rotorua
- Tauranga Hospital
- Indywidualna Specjalistyczna Praktyka Lekarska
- NZOZ "Eskulap"
- Podlaski Osrodek Kardiologii Janusz Korecki
- Centrum Medyczne KERmed
- 10 Wojskowy Szpital Kliniczny z Poliklinika SPZOZ
- Nzoz "Mada-Med"
- DIABET Centrum Medyczne s. c.
- ISPL w Dziedzinie Kardiologii lek.med. Krzysztof Cymerman
- NZOZ SCBK ProCordis
- Gabinet Kardiologiczno-Internistyczny
- Praktyka Lekarska dr n. med. Marek Bronisz
- Piotr Mader Diabetic Clinic NZOZ PD-I
- NZOZ Eskulap SC
- Ewa Mirek-Bryniarska Specjalistyczna Praktyka Lekarska
- LANDA' Specjalistyczne Gabinety Lekarskie
- Medyczne Centrum Diabetologiczno Endokrynologiczno
- Nzoz Cardiamed
- "CenterMed Lublin" Sp. z o.o.
- Indywidualna Praktyka Lekarska
- Zechowicz MEDEUSZ-PLUS
- Praktyka Lekarska Ewa Krzyzagorska
- NZOZ NEURO-KARD "Ilkowski i Partnerzy"
- Specjalistyczna Przychodnia Lekarska MEDIKARD (SPL Medikard)
- Specjalistyczny Gabinet Lekarski
- Lecznice Citomed Sp. z o.o.
- Praktyka Lekarska Pawlowicz Lidia
- Centrum Medyczne AMED
- Centrum Badawcze Wspolczesnej Terapii
- SNZOZ Fundacji PROCLINICA
- Centrum Zdrowia Wierzchoslawice
- Regionalna Poradnia Diabetologiczna
- Specjalistyczne Gabinety Lekarskie "Medicor PLUS"
- NZOZ ALL-MED Centrum Medyczne
- SP ZOZ w Lecznej
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Placebo Comparator
Arm Label
Lorcaserin hydrochloride (HCL)10 mg
Placebo
Arm Description
APD356 10 mg twice daily
Placebo twice daily
Outcomes
Primary Outcome Measures
Time From Randomization to First Occurrence of Major Adverse Cardiovascular Events (MACE) at Interim Analysis
The MACE events involved myocardial infarction (MI), stroke, or cardiovascular (CV) death. The outcome data was assessed using Kaplan-Meier estimate and Greenwood Formula.
Time From Randomization to First Occurrence of MACE+
The MACE+ events involved MI, stroke, or CV death or hospitalization for unstable angina or heart failure (HF), or any coronary revascularization. The outcome data was assessed using Kaplan-Meier estimate and Greenwood Formula.
Secondary Outcome Measures
Time From Randomization to Conversion to Type 2 Diabetes Mellitus (T2DM) for Participants With Prediabetes at Baseline
Time from randomization to conversion to T2DM was defined as first occurrence of any component of the 2013 American Diabetes Association (ADA) Diagnostic Criteria (ADA, 2013) in participants with prediabetes at baseline. The diagnostic criteria were met if a participant had unequivocal hyperglycemia (random plasma glucose greater than or equal to (>=) 200 milligram per deciliter (mg/dL) (11.1 millimole per liter [mmol/L]) with classic symptoms of hyperglycemia or hyperglycemic crisis) or any of the following criteria were observed and subsequently confirmed on repeat laboratory testing such as: glycosylated hemoglobin (HbA1c) >=to 6.5%; fasting plasma glucose (FPG) >=126 mg/dL (7.0 mmol/L); 2-hour plasma glucose >=200 mg/dL (11.1 mmol/L) by an oral glucose tolerance test (OGTT). The outcome data was assessed using Kaplan-Meier estimate and Greenwood Formula.
Time From Randomization to First Occurrence of the Individual Components of MACE+
The MACE+ events involved MI, stroke, or CV death or hospitalization for unstable angina or HF, or any coronary revascularization. The outcome data was assessed using Kaplan-Meier estimate and Greenwood Formula.
Time From Randomization to Event of All-cause Mortality
The outcome data was assessed using Kaplan-Meier estimate and Greenwood Formula.
Time From Randomization to Conversion to Normal Glucose Homeostasis in Participants With Prediabetes at Baseline
Normal glucose homeostasis was defined as HbA1c less than or equal to (<=) 5.6% and FPG < 100 mg/dL without any antidiabetic treatment. The outcome data was assessed using Kaplan-Meier estimate and Greenwood Formula.
Time From Randomization to Conversion to T2DM for Participants Without Any Type of Diabetes at Baseline
The outcome data was assessed using Kaplan-Meier estimate and Greenwood Formula.
Change From Baseline in HbA1c at Month 6 in Participants With T2DM at Baseline
Time From Randomization to Event of New Onset Renal Impairment or Worsening Existing Renal Impairment in All Participants
New onset/worsening of existing renal impairment was first occurrence of any events: microalbuminuria and macroalbuminuria (albumin-to-creatinine ratio [ACR] >=30mcg/mg and ACR>=300 mcg/mg in spot urine), worsening albuminuria (microalbuminuria at Baseline developed macroalbuminuria, ACR increased >=30% from Baseline during treatment), newly developed chronic kidney disease (CKD) (eGFR >=90 milliliter per minute per 1.73 [mL/min/1.73]body surface area (BSA) and without kidney damage at Baseline changed to CKD Stage 1/higher as per National Kidney Foundation [NKF] Guidelines [2002]) or worsening of CKD (CKD Stage 1/higher as per NKF Guidelines [2002] worsened to higher CKD stages during treatment), or doubling of serum creatinine (creatinine value at least 2 times Baseline value and >=1.5 mg/dL during treatment.), or any of the following: end-stage renal disease, renal transplant, renal death. The outcome data was assessed using Kaplan-Meier estimate and Greenwood Formula.
Time From Randomization to Event of New Onset Renal Impairment or Worsening Existing Renal Impairment in Participants With Prediabetes at Baseline
New onset/worsening of existing renal impairment was first occurrence of any events: microalbuminuria and macroalbuminuria (ACR >=30mcg/mg and ACR >=300 mcg/mg in spot urine), worsening albuminuria (microalbuminuria at baseline developed macroalbuminuria, ACR increased >=30% from baseline during treatment), CKD (eGFR >=90 mL/min/1.73 BSA and without kidney damage at baseline changed to CKD Stage 1/higher as per NKF Guidelines [2002]) or worsening of CKD (CKD Stage 1/higher as per NKF Guidelines [2002] worsened to higher CKD stages during treatment), or doubling of serum creatinine (creatinine value at least 2 times baseline value and >=1.5 mg/dL during treatment.), or any of the following: end-stage renal disease, renal transplant, renal death. The outcome data was assessed using Kaplan-Meier estimate and Greenwood Formula.
Time From Randomization to Event of New Onset Renal Impairment or Worsening Existing Renal Impairment in Participants With T2DM at Baseline
New onset/worsening of existing renal impairment was first occurrence of any events: microalbuminuria and macroalbuminuria (ACR >=30 mcg/mg and ACR >=300 mcg/mg in spot urine), worsening albuminuria (microalbuminuria at baseline developed macroalbuminuria, ACR increased >=30% from baseline during treatment), CKD (eGFR >=90 mL/min/1.73 BSA and without kidney damage at baseline changed to CKD Stage 1/higher as per NKF Guidelines [2002]) or worsening of CKD (CKD Stage 1/higher as per NKF Guidelines [2002] worsened to higher CKD stages during treatment), or doubling of serum creatinine (creatinine value at least 2 times baseline value and >=1.5 mg/dL during treatment.), or any of the following: end-stage renal disease, renal transplant, renal death. The outcome data was assessed using Kaplan-Meier estimate and Greenwood Formula.
Time From Randomization to Event of Improvement in Renal Function in Participants With T2DM at Baseline
Improvement in renal function was defined as first occurrence of regression of albuminuria or regression of CKD. Regression of albuminuria was defined as when participants with macroalbuminuria at baseline developed microalbuminuria or nonalbuminuria (ACR <30 mcg/mg in spot urine), or participants with microalbuminuria at baseline became nonalbuminuric, and ACR value decreased >= 30% from previous assessment during treatment. Regression of CKD defined as when participants with CKD Stage 1 or higher at baseline improved to normal or lower stages by NKF guidelines (eGFR >=90 with albuminuria at baseline improved to eGFR >=90 without albuminuria, or eGFR 60 to 89 at baseline became eGFR >=90 with or without albuminuria, or eGFR between 30 to 59 at baseline improved to >60 mL/min/1.73 BSA) during treatment. The outcome data was assessed using Kaplan-Meier estimate and Greenwood Formula.
Percentage of Participants Who Met FDA-Defined Valvulopathy in Echocardiographically Determined Heart Valve Changes
Percentage of Participants With FDA-Defined Valvulopathy at Baseline Who Demonstrated Worsened FDA-Defined Valvulopathy
Change From Baseline in Echocardiographically-Determined Pulmonary Arterial Systolic Pressure
Full Information
NCT ID
NCT02019264
First Posted
December 18, 2013
Last Updated
June 27, 2019
Sponsor
Eisai Inc.
Collaborators
Thrombolysis In Myocardial Infarction (TIMI) Academic Research Organization
1. Study Identification
Unique Protocol Identification Number
NCT02019264
Brief Title
A Study to Evaluate the Effect of Long-term Treatment With BELVIQ (Lorcaserin HCl) on the Incidence of Major Adverse Cardiovascular Events and Conversion to Type 2 Diabetes Mellitus in Obese and Overweight Subjects With Cardiovascular Disease or Multiple Cardiovascular Risk Factors
Acronym
CAMELLIA-TIMI
Official Title
A Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Effect of Long-term Treatment With BELVIQ (Lorcaserin HCl) on the Incidence of Major Adverse Cardiovascular Events and Conversion to Type 2 Diabetes Mellitus in Obese and Overweight Subjects With Cardiovascular Disease or Multiple Cardiovascular Risk Factors
Study Type
Interventional
2. Study Status
Record Verification Date
November 2017
Overall Recruitment Status
Completed
Study Start Date
January 24, 2014 (Actual)
Primary Completion Date
May 14, 2018 (Actual)
Study Completion Date
May 14, 2018 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Eisai Inc.
Collaborators
Thrombolysis In Myocardial Infarction (TIMI) Academic Research Organization
4. Oversight
Studies a U.S. FDA-regulated Drug Product
Yes
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group study in overweight and obese subjects with cardiovascular (CV) disease and/or multiple CV risk factors.
Detailed Description
Approximately 12,000 subjects will be randomized to two treatment groups in a ratio of 1:1, stratified by the presence of established CV disease (approximately 80%) or CV risk factors without established CV disease (approximately 20%). Subjects will receive lorcaserin HCl 10 mg BID or placebo BID. The study will consist of 2 phases: Prerandomization and Randomization. The Prerandomization Phase will last up to 30 days and consist of one visit during which subjects will be screened for eligibility. The Randomization Phase will consist of two periods: Treatment and Follow-up. The Treatment Period will last for approximately 5 years with approximately 18 visits and Follow-up period is 30 (+ or - 10 days) from the end of treatment visit.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Cardiovascular Disease, High Cardiovascular Risk, Obesity, Overweight, Type 2 Diabetes
Keywords
Diabetes, Cardiovascular Disease, Multiple Cardiovascular Risk Factors, Obesity, Overweight, MACE, Conversion to Diabetes
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 4
Interventional Study Model
Parallel Assignment
Masking
ParticipantInvestigator
Allocation
Randomized
Enrollment
14673 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Lorcaserin hydrochloride (HCL)10 mg
Arm Type
Experimental
Arm Description
APD356 10 mg twice daily
Arm Title
Placebo
Arm Type
Placebo Comparator
Arm Description
Placebo twice daily
Intervention Type
Drug
Intervention Name(s)
Lorcaserin hydrochloride
Other Intervention Name(s)
APD356, BELVIQ
Intervention Description
APD356 10 mg twice daily
Intervention Type
Drug
Intervention Name(s)
Placebo
Intervention Description
Placebo twice daily
Primary Outcome Measure Information:
Title
Time From Randomization to First Occurrence of Major Adverse Cardiovascular Events (MACE) at Interim Analysis
Description
The MACE events involved myocardial infarction (MI), stroke, or cardiovascular (CV) death. The outcome data was assessed using Kaplan-Meier estimate and Greenwood Formula.
Time Frame
Baseline up to Month 42
Title
Time From Randomization to First Occurrence of MACE+
Description
The MACE+ events involved MI, stroke, or CV death or hospitalization for unstable angina or heart failure (HF), or any coronary revascularization. The outcome data was assessed using Kaplan-Meier estimate and Greenwood Formula.
Time Frame
Baseline up to end of study (Month 56)
Secondary Outcome Measure Information:
Title
Time From Randomization to Conversion to Type 2 Diabetes Mellitus (T2DM) for Participants With Prediabetes at Baseline
Description
Time from randomization to conversion to T2DM was defined as first occurrence of any component of the 2013 American Diabetes Association (ADA) Diagnostic Criteria (ADA, 2013) in participants with prediabetes at baseline. The diagnostic criteria were met if a participant had unequivocal hyperglycemia (random plasma glucose greater than or equal to (>=) 200 milligram per deciliter (mg/dL) (11.1 millimole per liter [mmol/L]) with classic symptoms of hyperglycemia or hyperglycemic crisis) or any of the following criteria were observed and subsequently confirmed on repeat laboratory testing such as: glycosylated hemoglobin (HbA1c) >=to 6.5%; fasting plasma glucose (FPG) >=126 mg/dL (7.0 mmol/L); 2-hour plasma glucose >=200 mg/dL (11.1 mmol/L) by an oral glucose tolerance test (OGTT). The outcome data was assessed using Kaplan-Meier estimate and Greenwood Formula.
Time Frame
Baseline up to end of study (Month 56)
Title
Time From Randomization to First Occurrence of the Individual Components of MACE+
Description
The MACE+ events involved MI, stroke, or CV death or hospitalization for unstable angina or HF, or any coronary revascularization. The outcome data was assessed using Kaplan-Meier estimate and Greenwood Formula.
Time Frame
Baseline up to end of study (Month 56)
Title
Time From Randomization to Event of All-cause Mortality
Description
The outcome data was assessed using Kaplan-Meier estimate and Greenwood Formula.
Time Frame
Baseline up to end of study (Month 56)
Title
Time From Randomization to Conversion to Normal Glucose Homeostasis in Participants With Prediabetes at Baseline
Description
Normal glucose homeostasis was defined as HbA1c less than or equal to (<=) 5.6% and FPG < 100 mg/dL without any antidiabetic treatment. The outcome data was assessed using Kaplan-Meier estimate and Greenwood Formula.
Time Frame
Baseline up to end of study (Month 56)
Title
Time From Randomization to Conversion to T2DM for Participants Without Any Type of Diabetes at Baseline
Description
The outcome data was assessed using Kaplan-Meier estimate and Greenwood Formula.
Time Frame
Baseline up to end of study (Month 56)
Title
Change From Baseline in HbA1c at Month 6 in Participants With T2DM at Baseline
Time Frame
Baseline, and Month 6
Title
Time From Randomization to Event of New Onset Renal Impairment or Worsening Existing Renal Impairment in All Participants
Description
New onset/worsening of existing renal impairment was first occurrence of any events: microalbuminuria and macroalbuminuria (albumin-to-creatinine ratio [ACR] >=30mcg/mg and ACR>=300 mcg/mg in spot urine), worsening albuminuria (microalbuminuria at Baseline developed macroalbuminuria, ACR increased >=30% from Baseline during treatment), newly developed chronic kidney disease (CKD) (eGFR >=90 milliliter per minute per 1.73 [mL/min/1.73]body surface area (BSA) and without kidney damage at Baseline changed to CKD Stage 1/higher as per National Kidney Foundation [NKF] Guidelines [2002]) or worsening of CKD (CKD Stage 1/higher as per NKF Guidelines [2002] worsened to higher CKD stages during treatment), or doubling of serum creatinine (creatinine value at least 2 times Baseline value and >=1.5 mg/dL during treatment.), or any of the following: end-stage renal disease, renal transplant, renal death. The outcome data was assessed using Kaplan-Meier estimate and Greenwood Formula.
Time Frame
Baseline up to end of study (Month 56)
Title
Time From Randomization to Event of New Onset Renal Impairment or Worsening Existing Renal Impairment in Participants With Prediabetes at Baseline
Description
New onset/worsening of existing renal impairment was first occurrence of any events: microalbuminuria and macroalbuminuria (ACR >=30mcg/mg and ACR >=300 mcg/mg in spot urine), worsening albuminuria (microalbuminuria at baseline developed macroalbuminuria, ACR increased >=30% from baseline during treatment), CKD (eGFR >=90 mL/min/1.73 BSA and without kidney damage at baseline changed to CKD Stage 1/higher as per NKF Guidelines [2002]) or worsening of CKD (CKD Stage 1/higher as per NKF Guidelines [2002] worsened to higher CKD stages during treatment), or doubling of serum creatinine (creatinine value at least 2 times baseline value and >=1.5 mg/dL during treatment.), or any of the following: end-stage renal disease, renal transplant, renal death. The outcome data was assessed using Kaplan-Meier estimate and Greenwood Formula.
Time Frame
Baseline up to end of study (Month 56)
Title
Time From Randomization to Event of New Onset Renal Impairment or Worsening Existing Renal Impairment in Participants With T2DM at Baseline
Description
New onset/worsening of existing renal impairment was first occurrence of any events: microalbuminuria and macroalbuminuria (ACR >=30 mcg/mg and ACR >=300 mcg/mg in spot urine), worsening albuminuria (microalbuminuria at baseline developed macroalbuminuria, ACR increased >=30% from baseline during treatment), CKD (eGFR >=90 mL/min/1.73 BSA and without kidney damage at baseline changed to CKD Stage 1/higher as per NKF Guidelines [2002]) or worsening of CKD (CKD Stage 1/higher as per NKF Guidelines [2002] worsened to higher CKD stages during treatment), or doubling of serum creatinine (creatinine value at least 2 times baseline value and >=1.5 mg/dL during treatment.), or any of the following: end-stage renal disease, renal transplant, renal death. The outcome data was assessed using Kaplan-Meier estimate and Greenwood Formula.
Time Frame
Baseline up to end of study (Month 56)
Title
Time From Randomization to Event of Improvement in Renal Function in Participants With T2DM at Baseline
Description
Improvement in renal function was defined as first occurrence of regression of albuminuria or regression of CKD. Regression of albuminuria was defined as when participants with macroalbuminuria at baseline developed microalbuminuria or nonalbuminuria (ACR <30 mcg/mg in spot urine), or participants with microalbuminuria at baseline became nonalbuminuric, and ACR value decreased >= 30% from previous assessment during treatment. Regression of CKD defined as when participants with CKD Stage 1 or higher at baseline improved to normal or lower stages by NKF guidelines (eGFR >=90 with albuminuria at baseline improved to eGFR >=90 without albuminuria, or eGFR 60 to 89 at baseline became eGFR >=90 with or without albuminuria, or eGFR between 30 to 59 at baseline improved to >60 mL/min/1.73 BSA) during treatment. The outcome data was assessed using Kaplan-Meier estimate and Greenwood Formula.
Time Frame
Baseline up to end of study (Month 56)
Title
Percentage of Participants Who Met FDA-Defined Valvulopathy in Echocardiographically Determined Heart Valve Changes
Time Frame
Months 6 and 12
Title
Percentage of Participants With FDA-Defined Valvulopathy at Baseline Who Demonstrated Worsened FDA-Defined Valvulopathy
Time Frame
Months 6 and 12
Title
Change From Baseline in Echocardiographically-Determined Pulmonary Arterial Systolic Pressure
Time Frame
Baseline, Month 12
10. Eligibility
Sex
All
Minimum Age & Unit of Time
40 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria
BMI greater than or equal (>=) to 27 kilogram per meter square (kg/m^2)
Subjects able and willing to comply with a reduced-calorie diet and an increased physical activity program
Age >= to 40 years with established CV disease as defined by one of the following:
History of documented MI or ischemic stroke
History of peripheral artery disease
History of revascularization (coronary, carotid, or peripheral artery)
Significant unrevascularized coronary arterial stenosis
OR
Age >= to 55 years for women or >= to 50 years for men who have type 2 diabetes mellitus (T2DM) without established CV disease plus at least one of the following CV risk factors:
Hypertension, or currently receiving therapy for documented hypertension
Dyslipidemia, or currently taking prescription lipid-lowering therapy for documented dyslipidemia
Estimated glomerular filtration rate >= to 30 to less than equal (<=) to 60 mililitre per minute per 1.73 meter square (mL/min/1.73 m^) per the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation
High high sensitivity C-reactive protein (hsCRP)
Urinary albumin-to-creatinine ratio (ACR) >= 30 ug/mg
Subjects with T2DM may have a pre-existing or new diagnosis of T2DM. A new diagnosis of T2DM (ie, discovered at Screening) should be based on the 2013 American Diabetes Association (ADA) guidelines.
All T2DM subjects must have an HbA[1c] less (<) than 10% at Screening. If subjects are being treated, or upon diagnosis need to be treated with antidiabetic agents, the T2DM treatment regimen must be stable for at least 3 months prior to randomization.
Exclusion Criteria
Moderate or greater symptoms of congestive cardiac failure (New York Heart Association [NYHA] class III or IV)
Known left ventricular (LV) ejection fraction < than 20%
Moderate or greater symptoms of pulmonary hypertension (PH)
Known severe valvular disease
Moderate renal impairment, severe renal impairment (estimated glomerular filtration rate < 30 mL/min/1.73 m^ per the CKD-EPI equation based on ideal body weight), or end stage renal disease (ESRD)
Severe hepatic impairment
Use of other products intended for weight loss including prescription drugs, over-the-counter (OTC) drugs, and herbal preparations
Use of more than one other serotonergic drug
Use of drugs known to increase the risk for cardiac valvulopathy within 6 months prior to Screening including, but not limited to: pergolide, ergotamine, methysergide, cabergoline
History or evidence of clinically significant disease (e.g., malignancy, cardiac, respiratory, gastrointestinal, renal or psychiatric disease)
Use of lorcaserin HCl prior to Screening or hypersensitivity to lorcaserin HCl or any of the excipients
Planned bariatric surgery
Females must not be breastfeeding or pregnant
Facility Information:
Facility Name
Advanced Cardiovascular, LLC
City
Alexander City
State/Province
Alabama
ZIP/Postal Code
35010
Country
United States
Facility Name
North Alabama Research Center, LLC
City
Athens
State/Province
Alabama
ZIP/Postal Code
35611
Country
United States
Facility Name
UAB Medical Center
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35294
Country
United States
Facility Name
Coastal Clinical Research, Inc.
City
Mobile
State/Province
Alabama
ZIP/Postal Code
36608
Country
United States
Facility Name
Mobile Heart Specialists, PC
City
Mobile
State/Province
Alabama
ZIP/Postal Code
36608
Country
United States
Facility Name
Alaska Heart Institute
City
Anchorage
State/Province
Alaska
ZIP/Postal Code
99508
Country
United States
Facility Name
Connect Clinical Research Center, LCC
City
Chandler
State/Province
Arizona
ZIP/Postal Code
85224
Country
United States
Facility Name
Arrowhead Health Centers
City
Glendale
State/Province
Arizona
ZIP/Postal Code
85306
Country
United States
Facility Name
Phoenix Heart, PLLC
City
Glendale
State/Province
Arizona
ZIP/Postal Code
85306
Country
United States
Facility Name
Eclipse Clinical Research
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85745
Country
United States
Facility Name
NEA Baptist Clinic
City
Jonesboro
State/Province
Arkansas
ZIP/Postal Code
72401
Country
United States
Facility Name
Arkansas Cardiology Clinic
City
Little Rock
State/Province
Arkansas
ZIP/Postal Code
72205
Country
United States
Facility Name
Central Arkansas Veterans Healthcare System
City
Little Rock
State/Province
Arkansas
ZIP/Postal Code
72205
Country
United States
Facility Name
Preferred Research Partners
City
Little Rock
State/Province
Arkansas
ZIP/Postal Code
72211
Country
United States
Facility Name
Clinical Research Alliance
City
Alhambra
State/Province
California
ZIP/Postal Code
91801
Country
United States
Facility Name
Central Cardiology
City
Bakersfield
State/Province
California
ZIP/Postal Code
93308
Country
United States
Facility Name
Cardiovascular Research Foundation of Southern Cal
City
Beverly Hills
State/Province
California
ZIP/Postal Code
90210
Country
United States
Facility Name
Capitol Interventional Cardiology
City
Carmichael
State/Province
California
ZIP/Postal Code
95608
Country
United States
Facility Name
San Diego Costal Endocrinology Group AMC
City
Chula Vista
State/Province
California
ZIP/Postal Code
91911 3813
Country
United States
Facility Name
John Muir Physician Network Clinical Research Cent
City
Concord
State/Province
California
ZIP/Postal Code
94520
Country
United States
Facility Name
Medical Group of Encino
City
Encino
State/Province
California
ZIP/Postal Code
91436
Country
United States
Facility Name
Marin Endocrine Care & Research, Inc.
City
Greenbrae
State/Province
California
ZIP/Postal Code
94904
Country
United States
Facility Name
California Heart Specialists
City
Huntington Beach
State/Province
California
ZIP/Postal Code
92648
Country
United States
Facility Name
Del Rosario Medical Clinic, Inc.
City
Huntington Park
State/Province
California
ZIP/Postal Code
90255
Country
United States
Facility Name
Diabetes and Endocrine Associates
City
La Mesa
State/Province
California
ZIP/Postal Code
91942
Country
United States
Facility Name
La Mesa Cardiac Center
City
La Mesa
State/Province
California
ZIP/Postal Code
91942
Country
United States
Facility Name
Alliance Research Centers
City
Laguna Hills
State/Province
California
ZIP/Postal Code
92653
Country
United States
Facility Name
Torrance Clinical Research Institute, Inc.
City
Lomita
State/Province
California
ZIP/Postal Code
90717
Country
United States
Facility Name
Long Beach Center for Clinical Research
City
Long Beach
State/Province
California
ZIP/Postal Code
90807
Country
United States
Facility Name
Metabolic Clinic and Research Center
City
Los Angeles
State/Province
California
ZIP/Postal Code
90033
Country
United States
Facility Name
Beverly Hills Cardiology
City
Los Angeles
State/Province
California
ZIP/Postal Code
90067
Country
United States
Facility Name
VA Greater Los Angeles Health Care System
City
Los Angeles
State/Province
California
ZIP/Postal Code
90073
Country
United States
Facility Name
Clinical Interventions Research Institute
City
Mission Viejo
State/Province
California
ZIP/Postal Code
92692
Country
United States
Facility Name
Brigid Freyne MD Inc
City
Murrieta
State/Province
California
ZIP/Postal Code
92563
Country
United States
Facility Name
Valley Clinical Trials Inc
City
Northridge
State/Province
California
ZIP/Postal Code
91325
Country
United States
Facility Name
Carr Cardiology
City
Oceanside
State/Province
California
ZIP/Postal Code
92056
Country
United States
Facility Name
Northern California Clinical Research Center
City
Redding
State/Province
California
ZIP/Postal Code
96001
Country
United States
Facility Name
Sharp Rees-Stealy Medical Group, Inc.
City
San Diego
State/Province
California
ZIP/Postal Code
92101
Country
United States
Facility Name
University of California San Diego
City
San Diego
State/Province
California
ZIP/Postal Code
92103
Country
United States
Facility Name
Ritchken and First MD's
City
San Diego
State/Province
California
ZIP/Postal Code
92117
Country
United States
Facility Name
West Coast Research LLC
City
San Ramon
State/Province
California
ZIP/Postal Code
94582
Country
United States
Facility Name
Coastal Multi-Specialty Research
City
Santa Ana
State/Province
California
ZIP/Postal Code
92704
Country
United States
Facility Name
Westlake Medical Research
City
Thousand Oaks
State/Province
California
ZIP/Postal Code
91360
Country
United States
Facility Name
Harbor - UCLA Medical Center
City
Torrance
State/Province
California
ZIP/Postal Code
90509
Country
United States
Facility Name
Ronald Chochinov, MD
City
Ventura
State/Province
California
ZIP/Postal Code
93003
Country
United States
Facility Name
Ventura Cardiology Consultants
City
Ventura
State/Province
California
ZIP/Postal Code
93003
Country
United States
Facility Name
Infosphere Clinical Research
City
West Hills
State/Province
California
ZIP/Postal Code
91307
Country
United States
Facility Name
UCH-MHS Cardiac Research
City
Colorado Springs
State/Province
Colorado
ZIP/Postal Code
80909
Country
United States
Facility Name
Creekside Endocrine Associates PC
City
Denver
State/Province
Colorado
ZIP/Postal Code
80209
Country
United States
Facility Name
New West Physicians, PC
City
Golden
State/Province
Colorado
ZIP/Postal Code
80401
Country
United States
Facility Name
University of Colorado Health
City
Loveland
State/Province
Colorado
ZIP/Postal Code
80538
Country
United States
Facility Name
Connecticut Clinical Research, LLC
City
Bridgeport
State/Province
Connecticut
ZIP/Postal Code
06606
Country
United States
Facility Name
Bridgeport Hospital
City
Bridgeport
State/Province
Connecticut
ZIP/Postal Code
06610
Country
United States
Facility Name
Clinical Research Works, Bristol
City
Bristol
State/Province
Connecticut
ZIP/Postal Code
06010-5103
Country
United States
Facility Name
Cardiology Associates of Fairfield County, Norwalk
City
Norwalk
State/Province
Connecticut
ZIP/Postal Code
06851
Country
United States
Facility Name
Cardiology Associates of Fairfield County, P.C.
City
Stamford
State/Province
Connecticut
ZIP/Postal Code
06905
Country
United States
Facility Name
Stamford Therapeutics Consortium
City
Stamford
State/Province
Connecticut
ZIP/Postal Code
06905
Country
United States
Facility Name
Cardiology Associates of Fairfield County, P.C.
City
Trumbull
State/Province
Connecticut
ZIP/Postal Code
06611
Country
United States
Facility Name
Connecticut Heart and Vascular Center
City
Trumbull
State/Province
Connecticut
ZIP/Postal Code
06611
Country
United States
Facility Name
Chase Medical Research, LLC
City
Waterbury
State/Province
Connecticut
ZIP/Postal Code
06708
Country
United States
Facility Name
Red Clay Research
City
Newark
State/Province
Delaware
ZIP/Postal Code
19713
Country
United States
Facility Name
Alfieri Cardiology
City
Wilmington
State/Province
Delaware
ZIP/Postal Code
19803-3733
Country
United States
Facility Name
Aventura Heart Center
City
Aventura
State/Province
Florida
ZIP/Postal Code
33180
Country
United States
Facility Name
Zasa Clinical Research
City
Boynton Beach
State/Province
Florida
ZIP/Postal Code
33427
Country
United States
Facility Name
Meridien Research
City
Bradenton
State/Province
Florida
ZIP/Postal Code
34201
Country
United States
Facility Name
NOVA Southeastern University
City
Bradenton
State/Province
Florida
ZIP/Postal Code
34209
Country
United States
Facility Name
Bay Area Cardiology
City
Brandon
State/Province
Florida
ZIP/Postal Code
33511
Country
United States
Facility Name
Meridien Research, Brooksville
City
Brooksville
State/Province
Florida
ZIP/Postal Code
34601
Country
United States
Facility Name
Clearwater Cardiovascular and Interventional Cons.
City
Clearwater
State/Province
Florida
ZIP/Postal Code
33756
Country
United States
Facility Name
Clinical Research of South Florida
City
Coral Gables
State/Province
Florida
ZIP/Postal Code
33143
Country
United States
Facility Name
Holy Cross Medical Group
City
Coral Springs
State/Province
Florida
ZIP/Postal Code
33065
Country
United States
Facility Name
Cardiology Research Associates
City
Daytona Beach
State/Province
Florida
ZIP/Postal Code
32117
Country
United States
Facility Name
International Medical Research
City
Daytona Beach
State/Province
Florida
ZIP/Postal Code
32117
Country
United States
Facility Name
Asclepius Medical Research
City
Doral
State/Province
Florida
ZIP/Postal Code
33166
Country
United States
Facility Name
Fleming Island Center for Clinical Research
City
Fleming Island
State/Province
Florida
ZIP/Postal Code
32003
Country
United States
Facility Name
Integrative Research Associates, Inc.
City
Fort Lauderdale
State/Province
Florida
ZIP/Postal Code
33312
Country
United States
Facility Name
M & O Clinical Research, LLC
City
Fort Lauderdale
State/Province
Florida
ZIP/Postal Code
33316
Country
United States
Facility Name
Primary Care Associates
City
Fort Myers
State/Province
Florida
ZIP/Postal Code
33907
Country
United States
Facility Name
Florida Research Network, LLC
City
Gainesville
State/Province
Florida
ZIP/Postal Code
32605
Country
United States
Facility Name
George E. Platt, M.D.
City
Green Cove Springs
State/Province
Florida
ZIP/Postal Code
32043
Country
United States
Facility Name
Eastern Research, Inc.
City
Hialeah
State/Province
Florida
ZIP/Postal Code
33013
Country
United States
Facility Name
Larry K. Levinson, D.O., P.A.
City
Hollywood
State/Province
Florida
ZIP/Postal Code
33021
Country
United States
Facility Name
Research Physicians Network Alliance
City
Hollywood
State/Province
Florida
ZIP/Postal Code
33021
Country
United States
Facility Name
Pasco Cardiology Center
City
Hudson
State/Province
Florida
ZIP/Postal Code
34667
Country
United States
Facility Name
Nature Coast Clinical Research
City
Inverness
State/Province
Florida
ZIP/Postal Code
34452
Country
United States
Facility Name
University of Florida- Jacksonville
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32209
Country
United States
Facility Name
Jacksonville Center for Clinical Research
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32216
Country
United States
Facility Name
Westside Center for Clinical Research
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32216
Country
United States
Facility Name
Meridien Research
City
Lakeland
State/Province
Florida
ZIP/Postal Code
33805
Country
United States
Facility Name
Pharmax Research Clinic, Inc
City
Miami
State/Province
Florida
ZIP/Postal Code
33126-2956
Country
United States
Facility Name
Life Spring Research Foundation
City
Miami
State/Province
Florida
ZIP/Postal Code
33134
Country
United States
Facility Name
United Clinical Research Corp.
City
Miami
State/Province
Florida
ZIP/Postal Code
33155
Country
United States
Facility Name
Cardiovascular Research Center of South Florida
City
Miami
State/Province
Florida
ZIP/Postal Code
33173
Country
United States
Facility Name
South Florida Research Group LLC
City
Miami
State/Province
Florida
ZIP/Postal Code
33176
Country
United States
Facility Name
South Florida Research Solutions
City
Miramar
State/Province
Florida
ZIP/Postal Code
33025
Country
United States
Facility Name
Southwest Florida Research
City
Naples
State/Province
Florida
ZIP/Postal Code
34102
Country
United States
Facility Name
Ocala Research Institute, Inc
City
Ocala
State/Province
Florida
ZIP/Postal Code
34471
Country
United States
Facility Name
Oviedo Medical Research
City
Oviedo
State/Province
Florida
ZIP/Postal Code
32765
Country
United States
Facility Name
Cardiology Partners Clinical Research Institute
City
Palm Beach Gardens
State/Province
Florida
ZIP/Postal Code
33410-4304
Country
United States
Facility Name
Palm Beach Gardens Research Center
City
Palm Beach Gardens
State/Province
Florida
ZIP/Postal Code
33410
Country
United States
Facility Name
Research Physicians Network Alliance, Pembrok
City
Pembroke Pines
State/Province
Florida
ZIP/Postal Code
33025
Country
United States
Facility Name
South Florida Research Solutions
City
Pembroke Pines
State/Province
Florida
ZIP/Postal Code
33028
Country
United States
Facility Name
Cardiology Consultants
City
Pensacola
State/Province
Florida
ZIP/Postal Code
32501 6335
Country
United States
Facility Name
Clinical Research of Central Florida
City
Plant City
State/Province
Florida
ZIP/Postal Code
33563
Country
United States
Facility Name
Columbia Primary Care, LLC d/b/a Heart and Health Institute
City
Plantation
State/Province
Florida
ZIP/Postal Code
33324
Country
United States
Facility Name
St Johns Center for Clinical Research
City
Ponte Vedra
State/Province
Florida
ZIP/Postal Code
32081
Country
United States
Facility Name
Charlotte Heart Group Research Center
City
Port Charlotte
State/Province
Florida
ZIP/Postal Code
33952
Country
United States
Facility Name
Progressive Medical Research
City
Port Orange
State/Province
Florida
ZIP/Postal Code
32127
Country
United States
Facility Name
Brevard Cardiovascular Research Associates Inc
City
Rockledge
State/Province
Florida
ZIP/Postal Code
32955
Country
United States
Facility Name
Clearwater Cardiovascular and Interventional Cons.
City
Safety Harbor
State/Province
Florida
ZIP/Postal Code
34695
Country
United States
Facility Name
Bayfront Health St. Petersburg, Research
City
Saint Petersburg
State/Province
Florida
ZIP/Postal Code
33701
Country
United States
Facility Name
Meridien Research - St. Petersburg
City
Saint Petersburg
State/Province
Florida
ZIP/Postal Code
33709
Country
United States
Facility Name
Professional Health Care of Pinellas, INC
City
Saint Petersburg
State/Province
Florida
ZIP/Postal Code
33713
Country
United States
Facility Name
Intercoastal Medical Group
City
Sarasota
State/Province
Florida
ZIP/Postal Code
34239
Country
United States
Facility Name
Springfield Medical Center
City
Springfield
State/Province
Florida
ZIP/Postal Code
32401
Country
United States
Facility Name
Advanced Clinical Research Group
City
Stuart
State/Province
Florida
ZIP/Postal Code
34996
Country
United States
Facility Name
Meridien Research - Tampa
City
Tampa
State/Province
Florida
ZIP/Postal Code
33606
Country
United States
Facility Name
Stedman Clinical Trials
City
Tampa
State/Province
Florida
ZIP/Postal Code
33613
Country
United States
Facility Name
Healthpoint Medical Group, Inc
City
Tampa
State/Province
Florida
ZIP/Postal Code
33614
Country
United States
Facility Name
Interventional Cardiac Consultants
City
Trinity
State/Province
Florida
ZIP/Postal Code
34655
Country
United States
Facility Name
Lovelace Scientific Research
City
Venice
State/Province
Florida
ZIP/Postal Code
34292
Country
United States
Facility Name
Indian River Medical Center-Cardiology
City
Vero Beach
State/Province
Florida
ZIP/Postal Code
32960-3296
Country
United States
Facility Name
Cardiology Partners Clinical Research Institute
City
Wellington
State/Province
Florida
ZIP/Postal Code
33449
Country
United States
Facility Name
Cleveland Clinic Foundation
City
West Palm Beach
State/Province
Florida
ZIP/Postal Code
33401
Country
United States
Facility Name
Metabolic Research Institute
City
West Palm Beach
State/Province
Florida
ZIP/Postal Code
33401
Country
United States
Facility Name
Clinical Research of Central Florida
City
Winter Haven
State/Province
Florida
ZIP/Postal Code
33880
Country
United States
Facility Name
Atlanta Diabetes Associates, Endocrinology
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30318
Country
United States
Facility Name
Rockdale Medical-Research Associates
City
Conyers
State/Province
Georgia
ZIP/Postal Code
30094
Country
United States
Facility Name
Atlanta Heart Specialists
City
Cumming
State/Province
Georgia
ZIP/Postal Code
30041
Country
United States
Facility Name
Urban Family Practice Associates/Clinical Research Advantage
City
Marietta
State/Province
Georgia
ZIP/Postal Code
30067
Country
United States
Facility Name
Endocrine Research Solutions, Inc.
City
Roswell
State/Province
Georgia
ZIP/Postal Code
30076
Country
United States
Facility Name
Herman Clinical Research LLC
City
Suwanee
State/Province
Georgia
ZIP/Postal Code
30024
Country
United States
Facility Name
Atlanta Heart Specialists
City
Tucker
State/Province
Georgia
ZIP/Postal Code
30084
Country
United States
Facility Name
Northwest Heart Clinical Research, LLC
City
Arlington Heights
State/Province
Illinois
ZIP/Postal Code
60005
Country
United States
Facility Name
Cedar-Crosse Research Center
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60607
Country
United States
Facility Name
Northwestern University Feinberg School of Medicine
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60611
Country
United States
Facility Name
University of Chicago
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60637
Country
United States
Facility Name
Consultants in Cardiovascular Medicine
City
Elmhurst
State/Province
Illinois
ZIP/Postal Code
60126
Country
United States
Facility Name
Clinical Investigation Specialists, Inc. in Gurnee
City
Gurnee
State/Province
Illinois
ZIP/Postal Code
60031
Country
United States
Facility Name
Advanced CardioVascular Consultants, SC
City
Rock Island
State/Province
Illinois
ZIP/Postal Code
61201
Country
United States
Facility Name
Community Clinical Research Center
City
Anderson
State/Province
Indiana
ZIP/Postal Code
46011
Country
United States
Facility Name
American Health Network of IN, LLC, Avon
City
Avon
State/Province
Indiana
ZIP/Postal Code
46123
Country
United States
Facility Name
Premier Healthcare, LLC
City
Bloomington
State/Province
Indiana
ZIP/Postal Code
47403 3239
Country
United States
Facility Name
Deaconess Clinic, Inc.
City
Evansville
State/Province
Indiana
ZIP/Postal Code
47713
Country
United States
Facility Name
American Health Network of IN, LLC, Franklin
City
Franklin
State/Province
Indiana
ZIP/Postal Code
46131
Country
United States
Facility Name
American Health Network of IN, LLC, Greenfield
City
Greenfield
State/Province
Indiana
ZIP/Postal Code
46140
Country
United States
Facility Name
American Health Network - Thomas Moretto, MD
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46254-5471
Country
United States
Facility Name
Medical Consultants PC
City
Muncie
State/Province
Indiana
ZIP/Postal Code
47303
Country
United States
Facility Name
American Health Network of IN, LLC
City
Muncie
State/Province
Indiana
ZIP/Postal Code
47304
Country
United States
Facility Name
Cardiology Associates of Northwest Indiana, P.C
City
Munster
State/Province
Indiana
ZIP/Postal Code
46321
Country
United States
Facility Name
The University of Iowa, College of Public Health
City
Iowa City
State/Province
Iowa
ZIP/Postal Code
52242
Country
United States
Facility Name
Professional Research Network of Kansas, LLC
City
Wichita
State/Province
Kansas
ZIP/Postal Code
67203
Country
United States
Facility Name
Norton Heart Specialists
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40205 3338
Country
United States
Facility Name
Norton Heart Specialists
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40205-3338
Country
United States
Facility Name
L-MARC Research Center
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40213
Country
United States
Facility Name
Research Integrity LLC
City
Owensboro
State/Province
Kentucky
ZIP/Postal Code
42303
Country
United States
Facility Name
Central Maine Medical Center
City
Auburn
State/Province
Maine
ZIP/Postal Code
04210
Country
United States
Facility Name
Acadia Clinical Research, LLC
City
Bangor
State/Province
Maine
ZIP/Postal Code
04401
Country
United States
Facility Name
Eastern Maine Medical Center Northeast Cardiology Associates
City
Bangor
State/Province
Maine
ZIP/Postal Code
04401
Country
United States
Facility Name
Southern Maine Health Care/Maine Medical Center Research Ins
City
Biddeford
State/Province
Maine
ZIP/Postal Code
04005
Country
United States
Facility Name
InterMed, PA
City
Portland
State/Province
Maine
ZIP/Postal Code
04101
Country
United States
Facility Name
Medstar Cardiology Associates
City
Annapolis
State/Province
Maryland
ZIP/Postal Code
21401
Country
United States
Facility Name
Chesapeake Cardiovascular Associates, GBMC
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21204
Country
United States
Facility Name
Clinical Research, Inc
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21204
Country
United States
Facility Name
Medstar Union Memorial Heart Specialists
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21218
Country
United States
Facility Name
Medstar Union Memorial Hospital
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21218
Country
United States
Facility Name
Spectrum Clinical Research
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21229
Country
United States
Facility Name
Overlea Personal Physicians
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21236
Country
United States
Facility Name
Shahid Saeed MD, PC
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21237
Country
United States
Facility Name
Maryland Heart Associates, LLC
City
Glen Burnie
State/Province
Maryland
ZIP/Postal Code
21061
Country
United States
Facility Name
Klein & Associates, MD, PA
City
Hagerstown
State/Province
Maryland
ZIP/Postal Code
21740
Country
United States
Facility Name
MedStar Health Research Institute
City
Hyattsville
State/Province
Maryland
ZIP/Postal Code
20782
Country
United States
Facility Name
Lutherville Personal Physicians
City
Lutherville
State/Province
Maryland
ZIP/Postal Code
21093
Country
United States
Facility Name
MD Medical Research
City
Oxon Hill
State/Province
Maryland
ZIP/Postal Code
20745
Country
United States
Facility Name
Endocrine & Metabolic Consultants
City
Rockville
State/Province
Maryland
ZIP/Postal Code
20852
Country
United States
Facility Name
Lutherville Personal Physicians
City
Towson
State/Province
Maryland
ZIP/Postal Code
21204
Country
United States
Facility Name
Overlea Personal Physicians
City
Towson
State/Province
Maryland
ZIP/Postal Code
21204
Country
United States
Facility Name
Tufts Medical Center
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02111
Country
United States
Facility Name
MGH Weight Center
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02114
Country
United States
Facility Name
Brigham and Women's Hospital
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02115
Country
United States
Facility Name
New England Center for Clinical Research, IMCA
City
Fall River
State/Province
Massachusetts
ZIP/Postal Code
02720
Country
United States
Facility Name
Pentucket Medical Associates
City
Haverhill
State/Province
Massachusetts
ZIP/Postal Code
01830
Country
United States
Facility Name
ActivMed Practices
City
Methuen
State/Province
Massachusetts
ZIP/Postal Code
01844
Country
United States
Facility Name
Partners Community Physicians Organization
City
Natick
State/Province
Massachusetts
ZIP/Postal Code
01760
Country
United States
Facility Name
Partners Community Physicians Organization
City
Needham
State/Province
Massachusetts
ZIP/Postal Code
02494
Country
United States
Facility Name
Endeavor Medical Research PLC
City
Alpena
State/Province
Michigan
ZIP/Postal Code
49707
Country
United States
Facility Name
Cadillac Clinical Research, LLC
City
Cadillac
State/Province
Michigan
ZIP/Postal Code
49601
Country
United States
Facility Name
Westside Family Medical Center, PC
City
Kalamazoo
State/Province
Michigan
ZIP/Postal Code
49009
Country
United States
Facility Name
Cardiology Consultants of East Michigan
City
Lapeer
State/Province
Michigan
ZIP/Postal Code
48446
Country
United States
Facility Name
Marquette General Heart and Vascular Institute
City
Marquette
State/Province
Michigan
ZIP/Postal Code
49855
Country
United States
Facility Name
MidMichigan Medical Center
City
Midland
State/Province
Michigan
ZIP/Postal Code
48670
Country
United States
Facility Name
Nisus Research at McLaren Northern Michigan Hospital
City
Petoskey
State/Province
Michigan
ZIP/Postal Code
49770
Country
United States
Facility Name
Saint Joseph Mercy Oakland Hospital
City
Pontiac
State/Province
Michigan
ZIP/Postal Code
48341-2985
Country
United States
Facility Name
Remedica LLC
City
Rochester
State/Province
Michigan
ZIP/Postal Code
48307
Country
United States
Facility Name
Michigan CardioVascular Institute
City
Saginaw
State/Province
Michigan
ZIP/Postal Code
48601 1423
Country
United States
Facility Name
American Center for Clinical Trials
City
Southfield
State/Province
Michigan
ZIP/Postal Code
48034
Country
United States
Facility Name
Medical Research Associates, Inc.
City
Traverse City
State/Province
Michigan
ZIP/Postal Code
49684-2386
Country
United States
Facility Name
Michigan Heart
City
Ypsilanti
State/Province
Michigan
ZIP/Postal Code
48197
Country
United States
Facility Name
Minneapolis Heart Institute Foundation
City
Baxter
State/Province
Minnesota
ZIP/Postal Code
56425
Country
United States
Facility Name
Essentia Institute of Rural Health
City
Duluth
State/Province
Minnesota
ZIP/Postal Code
55805
Country
United States
Facility Name
MNCOME Clinic
City
Eagan
State/Province
Minnesota
ZIP/Postal Code
55123
Country
United States
Facility Name
Radiant Research, Inc.
City
Edina
State/Province
Minnesota
ZIP/Postal Code
55435
Country
United States
Facility Name
Minneapolis Heart Institute
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55407
Country
United States
Facility Name
Regions Hospital
City
Saint Paul
State/Province
Minnesota
ZIP/Postal Code
55101
Country
United States
Facility Name
Coast Cardiovascular Consultants PLLC
City
Gulfport
State/Province
Mississippi
ZIP/Postal Code
39501
Country
United States
Facility Name
Cardiology Associates Research, LLC
City
Tupelo
State/Province
Mississippi
ZIP/Postal Code
38801
Country
United States
Facility Name
Diabetes & Endocrinology Specialists, Inc.
City
Chesterfield
State/Province
Missouri
ZIP/Postal Code
63017
Country
United States
Facility Name
BodyAesthetic Research Center
City
Washington
State/Province
Missouri
ZIP/Postal Code
63090
Country
United States
Facility Name
Billings Clinic Research Center
City
Billings
State/Province
Montana
ZIP/Postal Code
59101
Country
United States
Facility Name
Montana Health Research Institute, Inc.
City
Billings
State/Province
Montana
ZIP/Postal Code
59102
Country
United States
Facility Name
Glacier View Cardiology PC
City
Kalispell
State/Province
Montana
ZIP/Postal Code
59901
Country
United States
Facility Name
Internal Medical Associates of Grand Island, PC
City
Grand Island
State/Province
Nebraska
ZIP/Postal Code
68803
Country
United States
Facility Name
Clinical Research Advantage / Rita Chuang, M.D.
City
Henderson
State/Province
Nevada
ZIP/Postal Code
89052
Country
United States
Facility Name
Clinical Research Advantage, Inc.
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89117
Country
United States
Facility Name
Clinical Research of South Nevada
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89121
Country
United States
Facility Name
Medicor Cardiology, PA
City
Bridgewater
State/Province
New Jersey
ZIP/Postal Code
08807-3060
Country
United States
Facility Name
Advanced Heart Care
City
Bridgewater
State/Province
New Jersey
ZIP/Postal Code
08807
Country
United States
Facility Name
UmiMed Center LLC
City
East Brunswick
State/Province
New Jersey
ZIP/Postal Code
08816
Country
United States
Facility Name
Cardiovascular Associates of the Delaware Valley
City
Elmer
State/Province
New Jersey
ZIP/Postal Code
08318-1715
Country
United States
Facility Name
Advocare Heights Primary Care
City
Haddon Heights
State/Province
New Jersey
ZIP/Postal Code
08035
Country
United States
Facility Name
Cardiovascular Associates of the Delaware Valley P
City
Haddon Heights
State/Province
New Jersey
ZIP/Postal Code
08035
Country
United States
Facility Name
NJ Heart
City
Linden
State/Province
New Jersey
ZIP/Postal Code
07036
Country
United States
Facility Name
Rutgers New Jersey Medical School
City
Mine Hill
State/Province
New Jersey
ZIP/Postal Code
07103
Country
United States
Facility Name
Cardiovascular Associates Delaware Valley Sewell
City
Sewell
State/Province
New Jersey
ZIP/Postal Code
08080-1715
Country
United States
Facility Name
Cardio Metabolic Institute
City
Somerset
State/Province
New Jersey
ZIP/Postal Code
08873
Country
United States
Facility Name
New Mexico Heart Institute, PA
City
Albuquerque
State/Province
New Mexico
ZIP/Postal Code
87102
Country
United States
Facility Name
Albany College of Medicine, Division of Endocrinology
City
Albany
State/Province
New York
ZIP/Postal Code
12206
Country
United States
Facility Name
Capital Cardiology Associates
City
Albany
State/Province
New York
ZIP/Postal Code
12211
Country
United States
Facility Name
United Medical Associates, PC
City
Binghamton
State/Province
New York
ZIP/Postal Code
13901
Country
United States
Facility Name
James J. Peters VA Medical Center, Bronx, NY
City
Bronx
State/Province
New York
ZIP/Postal Code
10468
Country
United States
Facility Name
Buffalo Heart Group
City
Buffalo
State/Province
New York
ZIP/Postal Code
14215
Country
United States
Facility Name
Regional Clinical Research, Inc.
City
Endwell
State/Province
New York
ZIP/Postal Code
13760
Country
United States
Facility Name
Long Island Gastrointestinal Research Group LLP
City
Great Neck
State/Province
New York
ZIP/Postal Code
11023
Country
United States
Facility Name
Long Island Heart Associates
City
Mineola
State/Province
New York
ZIP/Postal Code
11501
Country
United States
Facility Name
North Shore Diabetes and Endocrine Associates
City
New Hyde Park
State/Province
New York
ZIP/Postal Code
11042
Country
United States
Facility Name
Weill Cornell Medical College
City
New York
State/Province
New York
ZIP/Postal Code
10065
Country
United States
Facility Name
DiGiovanna Institute for Medical Education
City
North Massapequa
State/Province
New York
ZIP/Postal Code
11758
Country
United States
Facility Name
Hudson Valley Heart Center
City
Poughkeepsie
State/Province
New York
ZIP/Postal Code
12601
Country
United States
Facility Name
Rochester Clinical Research, Inc.
City
Rochester
State/Province
New York
ZIP/Postal Code
14609
Country
United States
Facility Name
Northwell Health Physician Partners Cardiology
City
Southampton
State/Province
New York
ZIP/Postal Code
11968
Country
United States
Facility Name
Capital Cardiology Associates
City
Troy
State/Province
New York
ZIP/Postal Code
12180
Country
United States
Facility Name
Great Lakes Medical Research
City
Westfield
State/Province
New York
ZIP/Postal Code
14787
Country
United States
Facility Name
Kernodle Clinic
City
Burlington
State/Province
North Carolina
ZIP/Postal Code
27215
Country
United States
Facility Name
Clinical Trials of America Inc.
City
Cary
State/Province
North Carolina
ZIP/Postal Code
27518
Country
United States
Facility Name
Metrolina Internal Medicine
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28204
Country
United States
Facility Name
PMG Research of Charlotte, LLC
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28209
Country
United States
Facility Name
Bland Clinic, PA
City
Greensboro
State/Province
North Carolina
ZIP/Postal Code
27401
Country
United States
Facility Name
Clinical Trials of America Inc. Hickory
City
Hickory
State/Province
North Carolina
ZIP/Postal Code
28601
Country
United States
Facility Name
Clinical Trials of America, Inc.
City
Hickory
State/Province
North Carolina
ZIP/Postal Code
28601
Country
United States
Facility Name
Peters Medical Research
City
High Point
State/Province
North Carolina
ZIP/Postal Code
27262
Country
United States
Facility Name
Clinical Trials of America, Inc.
City
Lenoir
State/Province
North Carolina
ZIP/Postal Code
28645
Country
United States
Facility Name
Diabetes & Endocrinology Consultants
City
Morehead City
State/Province
North Carolina
ZIP/Postal Code
28557
Country
United States
Facility Name
Burke Primary Care
City
Morganton
State/Province
North Carolina
ZIP/Postal Code
28655
Country
United States
Facility Name
Pinehurst Medical Clinic, Inc.
City
Pinehurst
State/Province
North Carolina
ZIP/Postal Code
28374-8798
Country
United States
Facility Name
Wake Research Associates, LLC
City
Raleigh
State/Province
North Carolina
ZIP/Postal Code
27612
Country
United States
Facility Name
PMG Research of Rocky Mount
City
Rocky Mount
State/Province
North Carolina
ZIP/Postal Code
27804
Country
United States
Facility Name
PMG Research of Salisbury
City
Salisbury
State/Province
North Carolina
ZIP/Postal Code
28144
Country
United States
Facility Name
Sanford Cardiology
City
Sanford
State/Province
North Carolina
ZIP/Postal Code
27330
Country
United States
Facility Name
Piedmont Healthcare
City
Statesville
State/Province
North Carolina
ZIP/Postal Code
28625
Country
United States
Facility Name
PMG Research of Wilmington
City
Wilmington
State/Province
North Carolina
ZIP/Postal Code
28401
Country
United States
Facility Name
PMG Research of Winston-Salem, LLC
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27103
Country
United States
Facility Name
Lillestol Research LLC
City
Fargo
State/Province
North Dakota
ZIP/Postal Code
58103
Country
United States
Facility Name
Aultman Hospital
City
Canton
State/Province
Ohio
ZIP/Postal Code
44710
Country
United States
Facility Name
The Lindner Research Center
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45219
Country
United States
Facility Name
Sentral Clinical Research
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45236
Country
United States
Facility Name
Delaware Research Group, LLC
City
Delaware
State/Province
Ohio
ZIP/Postal Code
43015
Country
United States
Facility Name
Awasty Research Network, LLC
City
Marion
State/Province
Ohio
ZIP/Postal Code
43302
Country
United States
Facility Name
Community Health Care
City
Massillon
State/Province
Ohio
ZIP/Postal Code
44646
Country
United States
Facility Name
Apex Medical Research Inc.
City
Springfield
State/Province
Ohio
ZIP/Postal Code
45505
Country
United States
Facility Name
Integris Cardiovascular Physicians LLC
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73112
Country
United States
Facility Name
Memorial Clinical Research
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73120
Country
United States
Facility Name
South Oklahoma Heart Research, LLC
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73135
Country
United States
Facility Name
Oklahoma Heart Institute
City
Tulsa
State/Province
Oklahoma
ZIP/Postal Code
74104
Country
United States
Facility Name
Vital Prospects Clinical Research Institute PC
City
Tulsa
State/Province
Oklahoma
ZIP/Postal Code
74136 7028
Country
United States
Facility Name
Blair Medical Associates
City
Altoona
State/Province
Pennsylvania
ZIP/Postal Code
16602
Country
United States
Facility Name
Clinical Research Associates of Central PA, LLC
City
Altoona
State/Province
Pennsylvania
ZIP/Postal Code
16602
Country
United States
Facility Name
Capital Area Research, LLC
City
Camp Hill
State/Province
Pennsylvania
ZIP/Postal Code
17011
Country
United States
Facility Name
Geisinger Health Clinic
City
Danville
State/Province
Pennsylvania
ZIP/Postal Code
17822
Country
United States
Facility Name
Geisinger Health System
City
Danville
State/Province
Pennsylvania
ZIP/Postal Code
17822
Country
United States
Facility Name
Doylestown Health Cardiology a Division of Doylestown Health
City
Doylestown
State/Province
Pennsylvania
ZIP/Postal Code
18901
Country
United States
Facility Name
Altoona Center for Clinical Research
City
Duncansville
State/Province
Pennsylvania
ZIP/Postal Code
16635
Country
United States
Facility Name
Liberty Family Practice
City
Erie
State/Province
Pennsylvania
ZIP/Postal Code
16508
Country
United States
Facility Name
Endocrine Clinical Research LLC
City
Feasterville
State/Province
Pennsylvania
ZIP/Postal Code
19053
Country
United States
Facility Name
Joseph Lamantia, DO
City
Indiana
State/Province
Pennsylvania
ZIP/Postal Code
15701
Country
United States
Facility Name
The Clinical Trial Center, LLC
City
Jenkintown
State/Province
Pennsylvania
ZIP/Postal Code
19046
Country
United States
Facility Name
Lycoming Internal Medicine, Inc.
City
Jersey Shore
State/Province
Pennsylvania
ZIP/Postal Code
17740
Country
United States
Facility Name
Berkley Hills Clinicals
City
Johnstown
State/Province
Pennsylvania
ZIP/Postal Code
15905-3443
Country
United States
Facility Name
Ilumina Clinical Associates, Johnstown
City
Johnstown
State/Province
Pennsylvania
ZIP/Postal Code
15905
Country
United States
Facility Name
Joseph Lamantia, DO
City
Johnstown
State/Province
Pennsylvania
ZIP/Postal Code
15905
Country
United States
Facility Name
Comprehensive Cardiology Consultants
City
Langhorne
State/Province
Pennsylvania
ZIP/Postal Code
19047
Country
United States
Facility Name
Detweiler Family Medicine and Associates PC
City
Lansdale
State/Province
Pennsylvania
ZIP/Postal Code
19446
Country
United States
Facility Name
Green & Seidner Family Practice Associates
City
Lansdale
State/Province
Pennsylvania
ZIP/Postal Code
19446
Country
United States
Facility Name
Capital Area Research LLC
City
Newport
State/Province
Pennsylvania
ZIP/Postal Code
17074
Country
United States
Facility Name
Endocrine Metabolic Associates
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19114
Country
United States
Facility Name
Pottstown Medical Specialists, Inc. (PMSI)
City
Pottstown
State/Province
Pennsylvania
ZIP/Postal Code
19464
Country
United States
Facility Name
Geisinger Clinic
City
Scranton
State/Province
Pennsylvania
ZIP/Postal Code
18508
Country
United States
Facility Name
Partners in Clinical Research
City
Cumberland
State/Province
Rhode Island
ZIP/Postal Code
02864
Country
United States
Facility Name
Radiant Research, Inc.
City
Greer
State/Province
South Carolina
ZIP/Postal Code
29650
Country
United States
Facility Name
Mountain View Clinical Research
City
Greer
State/Province
South Carolina
ZIP/Postal Code
29651
Country
United States
Facility Name
Palmetto Research Center, LLC
City
Spartanburg
State/Province
South Carolina
ZIP/Postal Code
29302
Country
United States
Facility Name
Brown Clinic, PLLP
City
Watertown
State/Province
South Dakota
ZIP/Postal Code
57201
Country
United States
Facility Name
PMG Research of Bristol, LLC
City
Bristol
State/Province
Tennessee
ZIP/Postal Code
37620
Country
United States
Facility Name
Chattanooga Research and Medicine (CHARM)
City
Chattanooga
State/Province
Tennessee
ZIP/Postal Code
37404
Country
United States
Facility Name
WR-ClinSearch, LLC
City
Chattanooga
State/Province
Tennessee
ZIP/Postal Code
37421
Country
United States
Facility Name
Wellmont CVA Heart Institute
City
Greeneville
State/Province
Tennessee
ZIP/Postal Code
37745-5810
Country
United States
Facility Name
Research Associates of Jackson
City
Jackson
State/Province
Tennessee
ZIP/Postal Code
38301-3930
Country
United States
Facility Name
Kore Cardiovascular Research
City
Jackson
State/Province
Tennessee
ZIP/Postal Code
38305
Country
United States
Facility Name
The Jackson Clinic, PA
City
Jackson
State/Province
Tennessee
ZIP/Postal Code
38305
Country
United States
Facility Name
Wellmont CVA Heart Institute
City
Johnson City
State/Province
Tennessee
ZIP/Postal Code
37604
Country
United States
Facility Name
Holston Medical Group
City
Kingsport
State/Province
Tennessee
ZIP/Postal Code
37660
Country
United States
Facility Name
Wellmont CVA Heart Institute
City
Kingsport
State/Province
Tennessee
ZIP/Postal Code
37660
Country
United States
Facility Name
The Endocrine Clinic
City
Memphis
State/Province
Tennessee
ZIP/Postal Code
38119
Country
United States
Facility Name
Cardiology Wellness Center
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37203
Country
United States
Facility Name
Central Texas Clinical Research, LLC
City
Austin
State/Province
Texas
ZIP/Postal Code
78705
Country
United States
Facility Name
Texas Diabetes & Endocrinology
City
Austin
State/Province
Texas
ZIP/Postal Code
78731
Country
United States
Facility Name
Texas Health Physicians Group
City
Carrollton
State/Province
Texas
ZIP/Postal Code
75007
Country
United States
Facility Name
Adriana Pop-Moody MD Clinic, PA
City
Corpus Christi
State/Province
Texas
ZIP/Postal Code
78404
Country
United States
Facility Name
Baylor Research Institute
City
Dallas
State/Province
Texas
ZIP/Postal Code
75024
Country
United States
Facility Name
Texas Health Physicians Group
City
Dallas
State/Province
Texas
ZIP/Postal Code
75218
Country
United States
Facility Name
Texas Health Physicians Group, Dallas
City
Dallas
State/Province
Texas
ZIP/Postal Code
75220
Country
United States
Facility Name
Research Institute of Dallas
City
Dallas
State/Province
Texas
ZIP/Postal Code
75231
Country
United States
Facility Name
Odilon Alvarado, M.D.
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76104
Country
United States
Facility Name
Texas Health Physicians Group Fort Worth
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76107
Country
United States
Facility Name
Tand R Clinic, PA
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76117
Country
United States
Facility Name
San Gabriel Clinical Research, LLC
City
Georgetown
State/Province
Texas
ZIP/Postal Code
78626
Country
United States
Facility Name
Angiocardiac Care of Texas PA
City
Houston
State/Province
Texas
ZIP/Postal Code
77025 5253
Country
United States
Facility Name
Oxford Clinical Research, LLC
City
Houston
State/Province
Texas
ZIP/Postal Code
77074
Country
United States
Facility Name
West Houston Area Clinical Trial Consultants, LLC
City
Houston
State/Province
Texas
ZIP/Postal Code
77094
Country
United States
Facility Name
Endocrine and Psychiatry Center
City
Houston
State/Province
Texas
ZIP/Postal Code
77095
Country
United States
Facility Name
Texas Health Physicians Group
City
Irving
State/Province
Texas
ZIP/Postal Code
75039
Country
United States
Facility Name
Texas Cardiology Associates of Houston
City
Kingwood
State/Province
Texas
ZIP/Postal Code
77339
Country
United States
Facility Name
Jalil Aziz Khan M.D., P.A.
City
Lewisville
State/Province
Texas
ZIP/Postal Code
75067
Country
United States
Facility Name
Midland Clinical Research Center
City
Midland
State/Province
Texas
ZIP/Postal Code
79707
Country
United States
Facility Name
Permian Research Foundation
City
Odessa
State/Province
Texas
ZIP/Postal Code
79761
Country
United States
Facility Name
Medical Clinic of North Texas
City
Plano
State/Province
Texas
ZIP/Postal Code
75023
Country
United States
Facility Name
Clinical Investigations of Texas, LLC
City
Plano
State/Province
Texas
ZIP/Postal Code
75075
Country
United States
Facility Name
Texas Diabetes
City
Round Rock
State/Province
Texas
ZIP/Postal Code
78681
Country
United States
Facility Name
Physician PrimeCare Research Institute, PLLC
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78228
Country
United States
Facility Name
Cardiology Clinic of San Antonio
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229
Country
United States
Facility Name
Radiant Research San Antonio
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229
Country
United States
Facility Name
Martin Diagnostic Clinic
City
Tomball
State/Province
Texas
ZIP/Postal Code
77375
Country
United States
Facility Name
Cardiovascular Associates of East Texas
City
Tyler
State/Province
Texas
ZIP/Postal Code
75701
Country
United States
Facility Name
Bay Area Total Health Medical Group
City
Webster
State/Province
Texas
ZIP/Postal Code
77598
Country
United States
Facility Name
Advanced Research Institute
City
Ogden
State/Province
Utah
ZIP/Postal Code
84405
Country
United States
Facility Name
Jean Brown Research
City
Salt Lake City
State/Province
Utah
ZIP/Postal Code
84124
Country
United States
Facility Name
Alexandria Clinical Research, LLC
City
Alexandria
State/Province
Virginia
ZIP/Postal Code
22304
Country
United States
Facility Name
Washington Center for Weight Management and Resear
City
Arlington
State/Province
Virginia
ZIP/Postal Code
22201
Country
United States
Facility Name
Burke Internal Medicine and Research
City
Burke
State/Province
Virginia
ZIP/Postal Code
22015
Country
United States
Facility Name
Cardiology Consultants of Danville, Inc.
City
Danville
State/Province
Virginia
ZIP/Postal Code
24541
Country
United States
Facility Name
Danville Internal Medicine, Inc
City
Danville
State/Province
Virginia
ZIP/Postal Code
24541
Country
United States
Facility Name
Virginia Heart
City
Falls Church
State/Province
Virginia
ZIP/Postal Code
22042-1262
Country
United States
Facility Name
Seven Corners Medical Research Center
City
Falls Church
State/Province
Virginia
ZIP/Postal Code
22044
Country
United States
Facility Name
INOVA Health Care Services
City
Manassas
State/Province
Virginia
ZIP/Postal Code
20109
Country
United States
Facility Name
Burke Internal Medicine and Research
City
Manassas
State/Province
Virginia
ZIP/Postal Code
20110
Country
United States
Facility Name
Manassas Clinical Research Center
City
Manassas
State/Province
Virginia
ZIP/Postal Code
20110
Country
United States
Facility Name
Health Research of Hampton Roads - Norfolk, Inc.
City
Norfolk
State/Province
Virginia
ZIP/Postal Code
23502
Country
United States
Facility Name
Clinical Research Associates of Tidewater
City
Norfolk
State/Province
Virginia
ZIP/Postal Code
23507
Country
United States
Facility Name
Clinical Research Partners
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23220
Country
United States
Facility Name
Virginia Cardiovascular Specialists
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23229
Country
United States
Facility Name
National Clinical Research-Richmond, Inc
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23294
Country
United States
Facility Name
Selma Medical Associates
City
Winchester
State/Province
Virginia
ZIP/Postal Code
22601
Country
United States
Facility Name
Larry D. Stonesifer, MD, Inc PS
City
Federal Way
State/Province
Washington
ZIP/Postal Code
98003
Country
United States
Facility Name
Seattle Women's
City
Seattle
State/Province
Washington
ZIP/Postal Code
98105
Country
United States
Facility Name
Rowan Research Inc.
City
Spokane
State/Province
Washington
ZIP/Postal Code
99218
Country
United States
Facility Name
MultiCare Research Institute
City
Tacoma
State/Province
Washington
ZIP/Postal Code
98405
Country
United States
Facility Name
Universal Research Group
City
Tacoma
State/Province
Washington
ZIP/Postal Code
98405
Country
United States
Facility Name
Wenatchee Valley Hospital & Clinics
City
Wenatchee
State/Province
Washington
ZIP/Postal Code
98801
Country
United States
Facility Name
Cardiology Associates of Bellin Health
City
Green Bay
State/Province
Wisconsin
ZIP/Postal Code
54301
Country
United States
Facility Name
Prevea Clinic, Inc
City
Green Bay
State/Province
Wisconsin
ZIP/Postal Code
54303
Country
United States
Facility Name
Clinical Investigation Specialists, Inc.
City
Kenosha
State/Province
Wisconsin
ZIP/Postal Code
53142
Country
United States
Facility Name
Meriter hospital Inc., DBA: UnityPoint Health-Meriter Heart
City
Madison
State/Province
Wisconsin
ZIP/Postal Code
53713
Country
United States
Facility Name
Marshfield Clinic
City
Marshfield
State/Province
Wisconsin
ZIP/Postal Code
54449
Country
United States
Facility Name
Aspirus Research Institute
City
Wausau
State/Province
Wisconsin
ZIP/Postal Code
54401
Country
United States
Facility Name
Coffs Harbour Health Campus
City
Coffs Harbour
State/Province
New South Wales
ZIP/Postal Code
2450
Country
Australia
Facility Name
Gosford Hospital, Cardiology Clinical Trials
City
Gosford
State/Province
New South Wales
ZIP/Postal Code
2250
Country
Australia
Facility Name
Liverpool Hospital
City
Liverpool
State/Province
New South Wales
ZIP/Postal Code
2170
Country
Australia
Facility Name
Illawarra Shoalhaven Local Health District, Clinical Trial and Research Unit
City
Wollongong
State/Province
New South Wales
ZIP/Postal Code
2500
Country
Australia
Facility Name
Wollongong Hospital
City
Wollongong
State/Province
New South Wales
ZIP/Postal Code
2500
Country
Australia
Facility Name
Core Research Group
City
Brisbane
State/Province
Queensland
ZIP/Postal Code
4064
Country
Australia
Facility Name
Princess Alexandra Hospital, Cardiology Research Department
City
Brisbane
State/Province
Queensland
ZIP/Postal Code
4102
Country
Australia
Facility Name
Royal Brisbane and Women's Hospital, Endocrinology Department
City
Herston
State/Province
Queensland
ZIP/Postal Code
4029
Country
Australia
Facility Name
HeartCare Partners Clinical Research Unit
City
Milton
State/Province
Queensland
ZIP/Postal Code
4064
Country
Australia
Facility Name
AusTrials Pty Ltd
City
Sherwood
State/Province
Queensland
ZIP/Postal Code
4075
Country
Australia
Facility Name
Gold Coast Hospital, Cardiovascular Research Centre
City
Southport
State/Province
Queensland
ZIP/Postal Code
4215
Country
Australia
Facility Name
New Royal Adelaide Hospital, Cardiology Department
City
Adelaide
State/Province
South Australia
ZIP/Postal Code
5000
Country
Australia
Facility Name
Adelaide Medical Research
City
Ashford
State/Province
South Australia
ZIP/Postal Code
5035
Country
Australia
Facility Name
Lyell McEwin Hospital, Department of Cardiology
City
Elizabeth Vale
State/Province
South Australia
ZIP/Postal Code
5112
Country
Australia
Facility Name
Heart and Vascular Institute
City
Fullarton
State/Province
South Australia
ZIP/Postal Code
SA 5063
Country
Australia
Facility Name
The Queen Elizabeth Hospital
City
Woodville South
State/Province
South Australia
ZIP/Postal Code
5011
Country
Australia
Facility Name
Ballarat Health Services
City
Ballarat
State/Province
Victoria
ZIP/Postal Code
3353
Country
Australia
Facility Name
Geelong Cardiology Research Unit, Barwon Health
City
Geelong
State/Province
Victoria
ZIP/Postal Code
3220
Country
Australia
Facility Name
Austin Health - Heidelberg Repatriation Hospital, Department of Medicine, Boronia Centre
City
Heidelberg Heights
State/Province
Victoria
ZIP/Postal Code
3081
Country
Australia
Facility Name
Avenue Cardiovascular Centre
City
Saint Kilda East
State/Province
Victoria
ZIP/Postal Code
3183
Country
Australia
Facility Name
Joondalup Cardiovascular Trials Foundation Inc
City
Joondalup
State/Province
Western Australia
ZIP/Postal Code
6027
Country
Australia
Facility Name
Fiona Stanley Hospital, Cardiology Research Department,CDO11
City
Murdoch
State/Province
Western Australia
ZIP/Postal Code
6150
Country
Australia
Facility Name
South Australian Medical Research Inst, Centre for Clinical Research
City
Adelaide
ZIP/Postal Code
5000
Country
Australia
Facility Name
The Partners Clinical Research Centre
City
Nassau
Country
Bahamas
Facility Name
LMC Clinical Research Inc. (Calgary)
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T2H 2G4
Country
Canada
Facility Name
Gordon and Leslie Diamond Health Care Centre
City
Vancouver
State/Province
British Columbia
ZIP/Postal Code
V5Z 1M9
Country
Canada
Facility Name
Nova Scotia Health Authority /QEII Health Sciences Centre
City
Halifax
State/Province
Nova Scotia
ZIP/Postal Code
B3H 3A7
Country
Canada
Facility Name
LMC Diabetes & Endocrinology - Brampton
City
Brampton
State/Province
Ontario
ZIP/Postal Code
L6S0C9
Country
Canada
Facility Name
McMaster University
City
Brampton
State/Province
Ontario
ZIP/Postal Code
L6Z 4N5
Country
Canada
Facility Name
JBN Medical Diagnostic Services Inc.
City
Burlington
State/Province
Ontario
ZIP/Postal Code
L7M 4Y1
Country
Canada
Facility Name
Aviva Clinical Trial Group In.
City
Burlington
State/Province
Ontario
ZIP/Postal Code
L7R 1E2
Country
Canada
Facility Name
Cambridge Cardiac Care Centre
City
Cambridge
State/Province
Ontario
ZIP/Postal Code
N1R 6V6
Country
Canada
Facility Name
Joanne F. Liutkus Medicine Professional Corp.
City
Cambridge
State/Province
Ontario
ZIP/Postal Code
N1R 7L6
Country
Canada
Facility Name
Saul Vizel Professional Medicine Corporation, Vizel Cardiac Research
City
Cambridge
State/Province
Ontario
ZIP/Postal Code
N1R 7R1
Country
Canada
Facility Name
LMC Diabetes & Endocrinology (Etobicoke)
City
Etobicoke
State/Province
Ontario
ZIP/Postal Code
M9R4E1
Country
Canada
Facility Name
Wharton Medical Clinic Clinical Trials Group Inc.
City
Hamilton
State/Province
Ontario
ZIP/Postal Code
L8L 5G8
Country
Canada
Facility Name
Saint Josephs Health Care London
City
London
State/Province
Ontario
ZIP/Postal Code
N6A 4V2
Country
Canada
Facility Name
LMC Diabetes & Endocrinoly
City
Markham
State/Province
Ontario
ZIP/Postal Code
L6B0P9
Country
Canada
Facility Name
New Market Cardiology Research Group
City
Newmarket
State/Province
Ontario
ZIP/Postal Code
L3Y 8C3
Country
Canada
Facility Name
Dr. Michael Heffernan
City
Oakville
State/Province
Ontario
ZIP/Postal Code
L6K 3W7
Country
Canada
Facility Name
LMC Clinical Research Inc. (Oakville)
City
Oakville
State/Province
Ontario
ZIP/Postal Code
L6M 4H8
Country
Canada
Facility Name
Dr. Cha
City
Oshawa
State/Province
Ontario
ZIP/Postal Code
L1J 2K1
Country
Canada
Facility Name
University of Ottawa Heart Institute
City
Ottawa
State/Province
Ontario
ZIP/Postal Code
K1Y 4W7
Country
Canada
Facility Name
Kawartha Cardiology Clinical Trials
City
Peterborough
State/Province
Ontario
ZIP/Postal Code
K9J 0B2
Country
Canada
Facility Name
Dr. Dinkar Shukla Professional Medicine Corporation
City
Sudbury
State/Province
Ontario
ZIP/Postal Code
P3E 6C3
Country
Canada
Facility Name
Dr Roger Labonte Professional Medicine Corp
City
Sudbury
State/Province
Ontario
ZIP/Postal Code
P3E3B8
Country
Canada
Facility Name
LMC Diabetes & Endocrinology (Thornhill)
City
Thornhill
State/Province
Ontario
ZIP/Postal Code
L4J8L7
Country
Canada
Facility Name
JJ DIG Research Ltd.
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M3J 1N2
Country
Canada
Facility Name
Keele Medical Place
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M3M 3E5
Country
Canada
Facility Name
LMC Clinical Research Inc. (Bayview)
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M4G 3E8
Country
Canada
Facility Name
St Michael's Hospital Health Centre
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5C 2T2
Country
Canada
Facility Name
ViaCar Recherche Clinique
City
Brossard
State/Province
Quebec
ZIP/Postal Code
J4X 1S4
Country
Canada
Facility Name
Q&T Research Outaouais Inc.
City
Gatineau
State/Province
Quebec
ZIP/Postal Code
J8Y 6S8
Country
Canada
Facility Name
ViaCar Recherche Clinique Inc.
City
Greenfield Park
State/Province
Quebec
ZIP/Postal Code
J4V 2G8
Country
Canada
Facility Name
Manna Research Inc
City
Levis
State/Province
Quebec
ZIP/Postal Code
G6W 0M6
Country
Canada
Facility Name
Clinique Sante Cardio MC
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H1T 3Y7
Country
Canada
Facility Name
Universitaire de Cardiologie et de Pneumologie de Quebec
City
Quebec City
State/Province
Quebec
ZIP/Postal Code
G1V 4G5
Country
Canada
Facility Name
Centre hospitalier régional de Lanaudière
City
Saint-Charles-Borromee
State/Province
Quebec
ZIP/Postal Code
J6E 6J2
Country
Canada
Facility Name
Recherche Clinique London
City
Sherbrooke
State/Province
Quebec
ZIP/Postal Code
J1J 2E3
Country
Canada
Facility Name
CardioVasc HR, Inc.
City
St Jean sur Richelieu
State/Province
Quebec
ZIP/Postal Code
J3A1C3
Country
Canada
Facility Name
ViaCar Recherche Clinique Inc.
City
St-Lambert
State/Province
Quebec
ZIP/Postal Code
J4P 2H4
Country
Canada
Facility Name
LMC Clinical Research Inc. (Montreal)
City
Ville Saint-Laurent
State/Province
Quebec
ZIP/Postal Code
H4T 1Z9
Country
Canada
Facility Name
Biomedica Research Group
City
Providencia
State/Province
Santiago
ZIP/Postal Code
7500710
Country
Chile
Facility Name
Sociedad Medica Cardiologica El Llano
City
San Miguel
State/Province
Santiago
ZIP/Postal Code
8910259
Country
Chile
Facility Name
Hospital Regional Concepcion
City
Concepcion
ZIP/Postal Code
4070038
Country
Chile
Facility Name
Cardiocob
City
Santiago
ZIP/Postal Code
7500520
Country
Chile
Facility Name
Servicios Medicos Godoy Ltda.
City
Santiago
ZIP/Postal Code
7500710
Country
Chile
Facility Name
Ccbr Cecim
City
Santiago
ZIP/Postal Code
8331143
Country
Chile
Facility Name
Centro Investigacion Clinica del Sur
City
Temuco
ZIP/Postal Code
4781156
Country
Chile
Facility Name
CECMI Ltda.
City
Temuco
ZIP/Postal Code
4813299
Country
Chile
Facility Name
ICLE
City
Guadalajara
State/Province
Jalisco
ZIP/Postal Code
44600
Country
Mexico
Facility Name
Private Medical Practice
City
Guadalajara
State/Province
Jalisco
ZIP/Postal Code
44657
Country
Mexico
Facility Name
IMED Clin Trials
City
Monterrey
State/Province
Nuevo Leon
ZIP/Postal Code
64020
Country
Mexico
Facility Name
Cardiolink ClinTrials S.C.
City
Monterrey
State/Province
Nuevo Leon
ZIP/Postal Code
64060
Country
Mexico
Facility Name
Centro de Estudios Clinicos y Especialidades Medicas S.C.
City
Monterrey
State/Province
Nuevo Leon
ZIP/Postal Code
64620
Country
Mexico
Facility Name
Hospital de Angeles Xalapa
City
Xalapa
State/Province
Veracruz
ZIP/Postal Code
91193
Country
Mexico
Facility Name
Fundacion Cardiovascular de Aguascalientes
City
Aguascalientes
ZIP/Postal Code
20230
Country
Mexico
Facility Name
Hospital Cardiologica Aguascalientes
City
Aguascalientes
ZIP/Postal Code
20230
Country
Mexico
Facility Name
Mentrials S.A.de C.V.
City
Distrito Federal
ZIP/Postal Code
06700
Country
Mexico
Facility Name
North Shore Hospital-Cardiology Research
City
Milford
State/Province
Auckland
ZIP/Postal Code
0622
Country
New Zealand
Facility Name
Middlemore Hospital
City
Papatoetoe
State/Province
Auckland
ZIP/Postal Code
2025
Country
New Zealand
Facility Name
North Shore Hospital - Diabetes Clinic
City
Takapuna
State/Province
Auckland
ZIP/Postal Code
0740
Country
New Zealand
Facility Name
Christchurch Hospital, Lipids
City
Christchurch
State/Province
Canterbury
ZIP/Postal Code
8011
Country
New Zealand
Facility Name
Christchurch Hospital, Cardiology Research
City
Christchurch
State/Province
Canterbury
ZIP/Postal Code
8811
Country
New Zealand
Facility Name
Dunedin Hospital
City
Dunedin
State/Province
Otago
ZIP/Postal Code
9016
Country
New Zealand
Facility Name
Taranaki Base Hospital
City
New Plymouth
State/Province
Taranaki
ZIP/Postal Code
4310
Country
New Zealand
Facility Name
Hutt Hospital, Cardiology Dept
City
Lower Hutt
State/Province
Wellington
ZIP/Postal Code
5010
Country
New Zealand
Facility Name
Auckland City Hospital
City
Auckland
ZIP/Postal Code
1148
Country
New Zealand
Facility Name
Hawkes Bay Regional Hospital
City
Hastings
ZIP/Postal Code
4120
Country
New Zealand
Facility Name
Nelson Hospital, Cardiology Department
City
Nelson
ZIP/Postal Code
7010
Country
New Zealand
Facility Name
Lakeland Clinical Trials, Rotorua
City
Rotorua
ZIP/Postal Code
3010
Country
New Zealand
Facility Name
Tauranga Hospital
City
Tauranga
ZIP/Postal Code
3112
Country
New Zealand
Facility Name
Indywidualna Specjalistyczna Praktyka Lekarska
City
Bezrzecze
ZIP/Postal Code
72-003
Country
Poland
Facility Name
NZOZ "Eskulap"
City
Biala Rawska
ZIP/Postal Code
96-230
Country
Poland
Facility Name
Podlaski Osrodek Kardiologii Janusz Korecki
City
Białystok
ZIP/Postal Code
15-875
Country
Poland
Facility Name
Centrum Medyczne KERmed
City
Bydgoszcz
ZIP/Postal Code
85-231
Country
Poland
Facility Name
10 Wojskowy Szpital Kliniczny z Poliklinika SPZOZ
City
Bydgoszcz
ZIP/Postal Code
85-681
Country
Poland
Facility Name
Nzoz "Mada-Med"
City
Chorzów
ZIP/Postal Code
41-500
Country
Poland
Facility Name
DIABET Centrum Medyczne s. c.
City
Chrzanów
ZIP/Postal Code
32-500
Country
Poland
Facility Name
ISPL w Dziedzinie Kardiologii lek.med. Krzysztof Cymerman
City
Gdynia
ZIP/Postal Code
81-157
Country
Poland
Facility Name
NZOZ SCBK ProCordis
City
Gdynia
ZIP/Postal Code
81-423
Country
Poland
Facility Name
Gabinet Kardiologiczno-Internistyczny
City
Gdynia
ZIP/Postal Code
81-472
Country
Poland
Facility Name
Praktyka Lekarska dr n. med. Marek Bronisz
City
Inowroclaw
ZIP/Postal Code
88-100
Country
Poland
Facility Name
Piotr Mader Diabetic Clinic NZOZ PD-I
City
Kamieniec Ząbkowicki
ZIP/Postal Code
57-230
Country
Poland
Facility Name
NZOZ Eskulap SC
City
Koluszki
ZIP/Postal Code
95-040
Country
Poland
Facility Name
Ewa Mirek-Bryniarska Specjalistyczna Praktyka Lekarska
City
Kraków
ZIP/Postal Code
30-082
Country
Poland
Facility Name
LANDA' Specjalistyczne Gabinety Lekarskie
City
Kraków
ZIP/Postal Code
31-156
Country
Poland
Facility Name
Medyczne Centrum Diabetologiczno Endokrynologiczno
City
Kraków
ZIP/Postal Code
31-261
Country
Poland
Facility Name
Nzoz Cardiamed
City
Legnica
ZIP/Postal Code
59-220
Country
Poland
Facility Name
"CenterMed Lublin" Sp. z o.o.
City
Lublin
ZIP/Postal Code
20-044
Country
Poland
Facility Name
Indywidualna Praktyka Lekarska
City
Mrągowo
ZIP/Postal Code
11-700
Country
Poland
Facility Name
Zechowicz MEDEUSZ-PLUS
City
Olsztyn
ZIP/Postal Code
10-010
Country
Poland
Facility Name
Praktyka Lekarska Ewa Krzyzagorska
City
Poznań
ZIP/Postal Code
61-655
Country
Poland
Facility Name
NZOZ NEURO-KARD "Ilkowski i Partnerzy"
City
Poznań
ZIP/Postal Code
61-853
Country
Poland
Facility Name
Specjalistyczna Przychodnia Lekarska MEDIKARD (SPL Medikard)
City
Płock
ZIP/Postal Code
09-402
Country
Poland
Facility Name
Specjalistyczny Gabinet Lekarski
City
Tarnów
ZIP/Postal Code
33-100
Country
Poland
Facility Name
Lecznice Citomed Sp. z o.o.
City
Toruń
ZIP/Postal Code
87-100
Country
Poland
Facility Name
Praktyka Lekarska Pawlowicz Lidia
City
Toruń
ZIP/Postal Code
87-100
Country
Poland
Facility Name
Centrum Medyczne AMED
City
Warszawa
ZIP/Postal Code
01-518
Country
Poland
Facility Name
Centrum Badawcze Wspolczesnej Terapii
City
Warszawa
ZIP/Postal Code
02-679
Country
Poland
Facility Name
SNZOZ Fundacji PROCLINICA
City
Warszawa
ZIP/Postal Code
03-973
Country
Poland
Facility Name
Centrum Zdrowia Wierzchoslawice
City
Wierzchosławice
ZIP/Postal Code
33-122
Country
Poland
Facility Name
Regionalna Poradnia Diabetologiczna
City
Wroclaw
ZIP/Postal Code
50-127
Country
Poland
Facility Name
Specjalistyczne Gabinety Lekarskie "Medicor PLUS"
City
Włocławek
ZIP/Postal Code
87-800
Country
Poland
Facility Name
NZOZ ALL-MED Centrum Medyczne
City
Łódź
ZIP/Postal Code
94-048
Country
Poland
Facility Name
SP ZOZ w Lecznej
City
Łęczna
ZIP/Postal Code
21-010
Country
Poland
12. IPD Sharing Statement
Citations:
PubMed Identifier
30586726
Citation
Scirica BM, Bohula EA, Dwyer JP, Qamar A, Inzucchi SE, McGuire DK, Keech AC, Smith SR, Murphy SA, Im K, Leiter LA, Gupta M, Patel T, Miao W, Perdomo C, Bonaca MP, Ruff CT, Sabatine MS, Wiviott SD; CAMELLIA-TIMI 61 Steering Committee and Investigators. Lorcaserin and Renal Outcomes in Obese and Overweight Patients in the CAMELLIA-TIMI 61 Trial. Circulation. 2019 Jan 15;139(3):366-375. doi: 10.1161/CIRCULATIONAHA.118.038341.
Results Reference
derived
PubMed Identifier
30293771
Citation
Bohula EA, Scirica BM, Inzucchi SE, McGuire DK, Keech AC, Smith SR, Kanevsky E, Murphy SA, Leiter LA, Dwyer JP, Corbalan R, Hamm C, Kaplan L, Nicolau JC, Ophuis TO, Ray KK, Ruda M, Spinar J, Patel T, Miao W, Perdomo C, Francis B, Dhadda S, Bonaca MP, Ruff CT, Sabatine MS, Wiviott SD; CAMELLIA-TIMI 61 Steering Committee Investigators. Effect of lorcaserin on prevention and remission of type 2 diabetes in overweight and obese patients (CAMELLIA-TIMI 61): a randomised, placebo-controlled trial. Lancet. 2018 Nov 24;392(10161):2269-2279. doi: 10.1016/S0140-6736(18)32328-6. Epub 2018 Oct 4.
Results Reference
derived
PubMed Identifier
30145941
Citation
Bohula EA, Wiviott SD, McGuire DK, Inzucchi SE, Kuder J, Im K, Fanola CL, Qamar A, Brown C, Budaj A, Garcia-Castillo A, Gupta M, Leiter LA, Weissman NJ, White HD, Patel T, Francis B, Miao W, Perdomo C, Dhadda S, Bonaca MP, Ruff CT, Keech AC, Smith SR, Sabatine MS, Scirica BM; CAMELLIA-TIMI 61 Steering Committee and Investigators. Cardiovascular Safety of Lorcaserin in Overweight or Obese Patients. N Engl J Med. 2018 Sep 20;379(12):1107-1117. doi: 10.1056/NEJMoa1808721. Epub 2018 Aug 26.
Results Reference
derived
PubMed Identifier
29803985
Citation
Bohula EA, Scirica BM, Fanola C, Inzucchi SE, Keech A, McGuire DK, Smith SR, Abrahamsen T, Francis BH, Miao W, Perdomo CA, Satlin A, Wiviott SD, Sabatine MS. Design and rationale for the Cardiovascular and Metabolic Effects of Lorcaserin in Overweight and Obese Patients-Thrombolysis in Myocardial Infarction 61 (CAMELLIA-TIMI 61) trial. Am Heart J. 2018 Aug;202:39-48. doi: 10.1016/j.ahj.2018.03.012. Epub 2018 Mar 29.
Results Reference
derived
Learn more about this trial
A Study to Evaluate the Effect of Long-term Treatment With BELVIQ (Lorcaserin HCl) on the Incidence of Major Adverse Cardiovascular Events and Conversion to Type 2 Diabetes Mellitus in Obese and Overweight Subjects With Cardiovascular Disease or Multiple Cardiovascular Risk Factors
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