Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Epilepsy (FRANCE)

This is an interventional treatment trial for Partial Epilepsy focused on measuring Deep Brain Stimulation, Anterior Nucleus of thalamus, Treatment refractory, Pharmacoresistant partial epilepsy, vagus nerve stimulation therapy Read More

Inclusion Criteria:

• Patient with focal or multifocal epilepsy with or without secondary generalized seizure inoperable at the time of inclusion
• Failure of pharmacological therapies (pharmacoresistant epilepsy) for over 4 years (persistent seizures despite at least two anti-epileptic treatments used at the optimal dose for at least 2 years)
• Failure of vagus nerve stimulation, defined as the persistence of crises considered debilitating after 2 years of VNS's treatment
• VNS failure in a patient treated with VNS, for less than 2 years. with stop early due to the worsening crisis
• Intelligence quotient above 55
• Have the written consent of the legal representative for patients under guardianship and minors
• Affiliation to the french social security system or equivalent
• People who signed the consent form
• Seizure frequency at least 4 crisis / month on average for at least 3 months, about 12 crisis in 3 months objectified by the neurologist during visit pre-inclusion, and confirmed by the neurologist after 3 months of Baseline during the inclusion visit

Exclusion Criteria:

• Patient with a generalized epilepsy Immediately
• Patient with a simple partial seizures (subjective manifestations only)
• Patient with a cons-indication for MRI, a serious intercurrent disease, a progressive brain tumor
• Patient with a suicide risk of in the six months preceding the inclusion visit (score ≥ 2 on item 10 of the Montgomery-Asberg Depression Rating Scale)
• Patient a surgical or anesthetic cons-indication
• Patient with anticoagulant or antiplatelet treatment in the long term
• Woman of childbearing potential without effective contraception, or pregnant or lactating
• People hospitalized without consent
• People deprived of freedom
• Patient currently participating in another clinical research, or who participated in a clinical study in the month preceding the pre-inclusion visit (except for any non-interventional research)