Methods of Chlorhexidine Cleansing to Prevent Ventilator-Associated Pneumonia (VAP) (VAP)
Ventilator-associated Pneumonia
About this trial
This is an interventional prevention trial for Ventilator-associated Pneumonia focused on measuring Ventilator-associated pneumonia VAP, Chlorhexidine, Oropharyngeal decontamination, Subglottic secretion drainage
Eligibility Criteria
Inclusion Criteria:
- Patients who are scheduled for endotracheal intubation and mechanical ventilation.
Exclusion Criteria:
- Patients who underwent endotracheal intubation or tracheotomy before study enrollment.
- Patients who underwent endotracheal intubation and mechanical ventilation within 30 days before study enrollment.
- Patients who require cardiopulmonary resuscitation.
- Patients with a history of emesis and aspiration before endotracheal intubation.
- Patients who are judged unsuitable for enrollment by clinicians.
Sites / Locations
- The General Hospital of Shenyang Military Region
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Experimental
Chlorhexidine before intubation
Chlorhexidine after intubation
Subglottic secretion drainage
0.9% sodium chloride injection
Group A: Oropharyngeal decontamination with chlorhexidine before intubation, n=48. Oral cleansing with chlorhexidine will be performed before endotracheal intubation, and every 6 hours after intubation.
Group B: Oropharyngeal decontamination with chlorhexidine after intubation, n=48. Oral cleansing with chlorhexidine will be performed every 6 hours after endotracheal intubation.
Group C: Suctioning of subglottic secretions, n=48. Oral cleansing with chlorhexidine will be performed before endotracheal intubation and every 6 hours after intubation, and fiberoptic bronchoscopy-guided suctioning of subglottic secretions will be performed at 10:00 a.m. every day. The procedure will be as follows: Routine cleaning of the bronchoscope. Oral or nasal insertion of the bronchoscope (according to the decision of the attending physician based on the patient's condition). Rinsing of the subglottic region with 5-20 mL of chlorhexidine solution followed by suctioning. The rinsing procedure will be repeated 3-5 times. Routine cleaning of the bronchoscope. The patient will be monitored during all procedures.
Group D: 0.9% sodium chloride injection, n=48. After endotracheal intubation, oral cleansing with normal saline will be performed every 6 hours.