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Use of High Intensity Interval Training as a Strategy to Minimize the Insulin Resistance Observed in Sleep Deprivation (HIIT)

Primary Purpose

Insulin Resistance, Sleep Deprivation

Status
Unknown status
Phase
Not Applicable
Locations
Study Type
Interventional
Intervention
High Intensity Interval Training
Sponsored by
Federal University of São Paulo
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional prevention trial for Insulin Resistance

Eligibility Criteria

18 Years - 35 Years (Adult)MaleAccepts Healthy Volunteers

Inclusion Criteria:

  • Healthy
  • Recreationally Active
  • Eutrophic
  • Sleep Duration about 7-8 hours

Exclusion Criteria:

  • No Smoking
  • Without Sleep disorders
  • Nondiabetic

Sites / Locations

    Arms of the Study

    Arm 1

    Arm 2

    Arm 3

    Arm 4

    Arm Type

    No Intervention

    No Intervention

    Experimental

    Experimental

    Arm Label

    Regular Sleep

    Sleep Deprivation

    HIIT + Regular Sleep

    HIIT + Sleep Deprivation

    Arm Description

    A single night of regular sleep

    A single night of sleep deprivation

    2 weeks of HIIT and after a single night of regular sleep.

    2 weeks of HIIT and after a single night of sleep deprivation

    Outcomes

    Primary Outcome Measures

    Change from Baseline in Blood Glucose
    Oral Glucose Tolerance Test (OGTT) is performed after at least 8 hours of fasting overnight, by oral administration of standard dose of 75g anhydrous glucose dissolved in water (dextrose). The plasma glucose levels are fasting measured (before administration of glucose state) and 30, 60, 90, 120, 180 and 240 minutes after administration. Volunteers will be advised to follow the same eating patterns before testing.

    Secondary Outcome Measures

    Full Information

    First Posted
    April 25, 2014
    Last Updated
    May 7, 2015
    Sponsor
    Federal University of São Paulo
    Collaborators
    Fundação de Amparo à Pesquisa do Estado de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico
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    1. Study Identification

    Unique Protocol Identification Number
    NCT02125656
    Brief Title
    Use of High Intensity Interval Training as a Strategy to Minimize the Insulin Resistance Observed in Sleep Deprivation
    Acronym
    HIIT
    Official Title
    Use of High Intensity Interval Training as a Strategy to Minimize the Insulin Resistance Observed in Sleep Deprivation
    Study Type
    Interventional

    2. Study Status

    Record Verification Date
    May 2015
    Overall Recruitment Status
    Unknown status
    Study Start Date
    February 2014 (undefined)
    Primary Completion Date
    July 2014 (Actual)
    Study Completion Date
    May 2015 (Anticipated)

    3. Sponsor/Collaborators

    Responsible Party, by Official Title
    Principal Investigator
    Name of the Sponsor
    Federal University of São Paulo
    Collaborators
    Fundação de Amparo à Pesquisa do Estado de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico

    4. Oversight

    Data Monitoring Committee
    Yes

    5. Study Description

    Brief Summary
    Sleep is an essential biological process for life and great value to functions such as learning, memory processing , cell and brain repair. Recently, new evidence points to the relationship between lack of sleep and carbohydrate metabolism , establishing a framework for insulin resistance observed in studies with restriction and sleep deprivation on several nights and in a single night . To reverse this process , one of the most effective strategies is physical exercise and part listed in the literature as a non-pharmacological tool for prevention and health promotion , as well as in the treatment of some diseases . However , the pace of modern society causes people to practice less physical exercise , lack of time being the main reason . In this scenario, the High Intensity Interval Training ( HIIT ) emerges as a powerful strategy that induces major changes optimizing the time spent on such activity. Considering the benefits of this mode , the purpose of this study is to investigate the effects of high-intensity interval training in the context of insulin resistance observed during sleep deprivation. Will be recruited 20 male volunteers, aged between 18 and 35 years old, healthy, with normal sleep duration equivalent to 7-8 hours / night, not smoking and regular eating habits. They will be submitted to a protocol of 6 sessions of high-intensity interval training for two weeks, and since the end period, sleep normally, or be deprived of sleep for 24 hours. Biochemical (thyroid hormones, cortisol, glucagon, free fatty acid, cholesterol, glucose and insulin) will be undertaken as well as evaluation of body composition by plethysmography, basal metabolic rate by indirect calorimetry and insulin sensitivity through Oral Glucose Tolerance Test (OGTT) before and after the training period.

    6. Conditions and Keywords

    Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
    Insulin Resistance, Sleep Deprivation

    7. Study Design

    Primary Purpose
    Prevention
    Study Phase
    Not Applicable
    Interventional Study Model
    Crossover Assignment
    Masking
    None (Open Label)
    Allocation
    Non-Randomized
    Enrollment
    15 (Anticipated)

    8. Arms, Groups, and Interventions

    Arm Title
    Regular Sleep
    Arm Type
    No Intervention
    Arm Description
    A single night of regular sleep
    Arm Title
    Sleep Deprivation
    Arm Type
    No Intervention
    Arm Description
    A single night of sleep deprivation
    Arm Title
    HIIT + Regular Sleep
    Arm Type
    Experimental
    Arm Description
    2 weeks of HIIT and after a single night of regular sleep.
    Arm Title
    HIIT + Sleep Deprivation
    Arm Type
    Experimental
    Arm Description
    2 weeks of HIIT and after a single night of sleep deprivation
    Intervention Type
    Other
    Intervention Name(s)
    High Intensity Interval Training
    Intervention Description
    6 sessions in 2 weeks (Monday, Wednesday and Friday). Each training session will consist of repeated high-intensity efforts in a workload that matches the peak oxygen uptake for 60 seconds. These sprints are interspersed with active recovery for 75 seconds on low intensity (30W). The training sessions will have three minutes of heating in 30W. There will be 8 shots in the first and second session, 10 shots in the third and fourth session and 12 shots in the fifth and sixth session.
    Primary Outcome Measure Information:
    Title
    Change from Baseline in Blood Glucose
    Description
    Oral Glucose Tolerance Test (OGTT) is performed after at least 8 hours of fasting overnight, by oral administration of standard dose of 75g anhydrous glucose dissolved in water (dextrose). The plasma glucose levels are fasting measured (before administration of glucose state) and 30, 60, 90, 120, 180 and 240 minutes after administration. Volunteers will be advised to follow the same eating patterns before testing.
    Time Frame
    Change from Baseline in Blood Glucose at 2 weeks of high intensity interval training

    10. Eligibility

    Sex
    Male
    Minimum Age & Unit of Time
    18 Years
    Maximum Age & Unit of Time
    35 Years
    Accepts Healthy Volunteers
    Accepts Healthy Volunteers
    Eligibility Criteria
    Inclusion Criteria: Healthy Recreationally Active Eutrophic Sleep Duration about 7-8 hours Exclusion Criteria: No Smoking Without Sleep disorders Nondiabetic
    Overall Study Officials:
    First Name & Middle Initial & Last Name & Degree
    Jorge FT de Souza, Msc
    Organizational Affiliation
    Federal University of São Paulo
    Official's Role
    Principal Investigator

    12. IPD Sharing Statement

    Learn more about this trial

    Use of High Intensity Interval Training as a Strategy to Minimize the Insulin Resistance Observed in Sleep Deprivation

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