The Effect of Artificial Sweeteners (AFS) on Sweetness Sensitivity, Preference and Brain Response in Adults (AFS-adult)
Impairment of Oral Perception, Insulin Resistance
About this trial
This is an interventional basic science trial for Impairment of Oral Perception
Eligibility Criteria
Inclusion Criteria:
- Healthy
- Fluent in English
- Right handed
Exclusion Criteria:
- History of oral nerve damage,
- presence of known taste or smell disorder,
- food allergies or sensitivities (for example nuts, lactose, artificial sweeteners),
- history of CNS disease,
- diabetes,
- history of DSM-IV major psychiatric disorder,
- including alcohol and substance abuse,
- chronic use of medication that may affect taste,
- conditions that may interfere with gustatory or olfactory perception (colds, seasonal allergies,
- recent smoking history),
- aberrant stimulus ratings,
- contra-indication for fMRI,
- uncomfortable swallowing in supine position,
- discomfort or anxiety associated with insertion an intravenous catheter,
- regular artificial sweetener use.
Sites / Locations
- Yale University
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Experimental
Sucralose
Sucrose
Sucralose + maltodextrin
Sucralose + Sucrose
Participants will rate sweetness, sourness, saltiness, bitterness and umami intensity of various taste stimuli. Next they will consume a flavored beverage with sucralose.
Participants will rate sweetness, sourness, saltiness, bitterness and umami intensity of various taste stimuli. Next they will consume a flavored beverage with sucrose.
Participants will rate sweetness, sourness, saltiness, bitterness and umami intensity of various taste stimuli. Next they will consume a flavored beverage with Splenda + maltodextrin .
Participants will rate sweetness, sourness, saltiness, bitterness and umami intensity of various taste stimuli. Next they will consume a flavored beverage with Splenda + sucrose.