Atorvastatin in Active Vitiligo

This is an interventional treatment trial for Vitiligo Read More

Inclusion Criteria:

• Active non-segmental vitiligo defined by

  • Non- segmental vitiligo with new patches or extension of old lesions during the last 3 months AND
  • Presence of hypochromic aspect under Wood's lamp examination and/or perifollicular hypopigmentation under Wood's lamp examination
• Patient requiring a treatment by UVB
• Signed informed consent document
• Patient registered to the French Social Security

Exclusion Criteria:

• - Segmental or mixed vitiligo
• Pregnant (urinary pregnancy test will be done) or lactating patients
• Allergy to statin medications
• Use of statin or fibrate medications due to cardiac risks
• Use of statin medications in the past 8 weeks
• Use of any medications contraindicated with use of statin medications
• Use of vitiligo treatments (both topicals and phototherapy) in the past 4 weeks
• Treatment with immunomodulating oral medications in the past 4 weeks
• Hepatic disease and/or dysfunction
• Renal dysfunction
• Personal or familial history of myopathy or personal history of rhabdomyolysis or elevated baseline creatinine kinase
• Alcohol or drug abuse
• Untreated hypothyroidism
• Personal history of skin cancer
• Any other clinically significant findings that, in the opinion of the Principal Investigator, might interfere with study evaluations or pose a risk to subject safety during the study.
• Patients assessed to be uncooperative
• Participants in other clinical studies