Back to resultsResistance Training in Patients With Parkinson's Disease.
Primary Purpose
Parkinson Disease
Status
Completed
Phase
Not Applicable
Locations
Study Type
Interventional
Intervention
Resistance Training
Lectures on the disease
Sponsored by
About this trial
This is an interventional treatment trial for Parkinson Disease
Eligibility Criteria
Inclusion Criteria:
- Medical neurologist confirmation of 1-3 Hoehn and Yahr stages,
- age between 50 and 80 years old;
- and physician attested to participate in the resistance training program.
Exclusion Criteria:
- Diagnostic of any other neurological disease, cardiovascular disease, hematologic or orthopedic disorders;
- and motor fluctuations or severe dyskinesia that could affect their ability to perform the experimental protocol.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Other
Arm Label
Training group
Control group
Arm Description
9-week resistance training program
'Lectures on the disease'
Outcomes
Primary Outcome Measures
Bradykinesia measured with Unified Parkinson's Disease Rating Scale, section III
Functional Performance measured with Ten Meters Walk Test.
Secondary Outcome Measures
Muscle strength measured with isokinetic peak torque.
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT02447146
Brief Title
Resistance Training in Patients With Parkinson's Disease.
Official Title
Effects of Resistance Training on Bradykinesia and Physical Function in Patients With Parkinson's Disease.
Study Type
Interventional
2. Study Status
Record Verification Date
May 2015
Overall Recruitment Status
Completed
Study Start Date
January 2013 (undefined)
Primary Completion Date
June 2014 (Actual)
Study Completion Date
December 2014 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
University of Brasilia
4. Oversight
Data Monitoring Committee
No
5. Study Description
Brief Summary
This is a controlled trial to assess the effects of resistance training on bradykinesia and physical function in patients with Parkinson's Disease. Forty patients diagnosed with Parkinson Disease stage 1 to 3 of the Hoehn and Yahr scale took part in the study and were allocated into 2 groups; Training Group performed a 9-week RT program twice a week while the Control Group attended lectures on the disease.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Parkinson Disease
7. Study Design
Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
Outcomes Assessor
Allocation
Non-Randomized
Enrollment
40 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Training group
Arm Type
Experimental
Arm Description
9-week resistance training program
Arm Title
Control group
Arm Type
Other
Arm Description
'Lectures on the disease'
Intervention Type
Other
Intervention Name(s)
Resistance Training
Intervention Description
The TG performed the RT program using weight machines. Before the training period, participants underwent three weeks with eight familiarization sessions to ensure proper technique execution. The protocol aimed to workout major muscle groups and involved the following exercises: chest press, knee extension, hamstrings curl, leg press, and seated row. Training sessions lasted approximately 50-60 minutes with 2 sets of 10-12 repetitions until fatigue.
Intervention Type
Other
Intervention Name(s)
Lectures on the disease
Intervention Description
The control group attended an orientation program with lectures on health, quality of life and scientific update on disease.
Primary Outcome Measure Information:
Title
Bradykinesia measured with Unified Parkinson's Disease Rating Scale, section III
Time Frame
One time point; after the end of 9-week resistance training
Title
Functional Performance measured with Ten Meters Walk Test.
Time Frame
One time point; after the end of 9-week resistance training
Secondary Outcome Measure Information:
Title
Muscle strength measured with isokinetic peak torque.
Time Frame
One time point; after the end of 9-week resistance training
10. Eligibility
Sex
All
Minimum Age & Unit of Time
50 Years
Maximum Age & Unit of Time
80 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
Medical neurologist confirmation of 1-3 Hoehn and Yahr stages,
age between 50 and 80 years old;
and physician attested to participate in the resistance training program.
Exclusion Criteria:
Diagnostic of any other neurological disease, cardiovascular disease, hematologic or orthopedic disorders;
and motor fluctuations or severe dyskinesia that could affect their ability to perform the experimental protocol.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Ricardo Oliveira, PhD
Organizational Affiliation
College of Physical Education - University of Brasilia
Official's Role
Study Director
12. IPD Sharing Statement
Citations:
PubMed Identifier
16773643
Citation
Dibble LE, Hale TF, Marcus RL, Droge J, Gerber JP, LaStayo PC. High-intensity resistance training amplifies muscle hypertrophy and functional gains in persons with Parkinson's disease. Mov Disord. 2006 Sep;21(9):1444-52. doi: 10.1002/mds.20997.
Results Reference
background
PubMed Identifier
20306270
Citation
Falvo MJ, Sirevaag EJ, Rohrbaugh JW, Earhart GM. Resistance training induces supraspinal adaptations: evidence from movement-related cortical potentials. Eur J Appl Physiol. 2010 Jul;109(5):923-33. doi: 10.1007/s00421-010-1432-8. Epub 2010 Mar 21.
Results Reference
background
PubMed Identifier
18534554
Citation
Fisher BE, Wu AD, Salem GJ, Song J, Lin CH, Yip J, Cen S, Gordon J, Jakowec M, Petzinger G. The effect of exercise training in improving motor performance and corticomotor excitability in people with early Parkinson's disease. Arch Phys Med Rehabil. 2008 Jul;89(7):1221-9. doi: 10.1016/j.apmr.2008.01.013. Epub 2008 Jun 13.
Results Reference
background
PubMed Identifier
19425085
Citation
Allen NE, Canning CG, Sherrington C, Fung VS. Bradykinesia, muscle weakness and reduced muscle power in Parkinson's disease. Mov Disord. 2009 Jul 15;24(9):1344-51. doi: 10.1002/mds.22609.
Results Reference
result
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Resistance Training in Patients With Parkinson's Disease.
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