Effects of Stimulation Patterns of Deep Brain Stimulation
Parkinson Disease, Essential Tremor, Multiple Sclerosis
About this trial
This is an interventional basic science trial for Parkinson Disease focused on measuring Deep Brain Stimulation, Movement Disorders, Parkinson Disease, Essential Tremor, Subthalamic Nucleus, Globus Pallidus, Thalamus, Tremor, Bradykinesia, Temporal Pattern, Electrical Stimulation, Neuromodulation, PD, ET, MS, STN, GPi, DBS, Nervous System Diseases, Neurodegenerative Diseases
Eligibility Criteria
Inclusion Criteria:
- Diagnosis of Parkinson's Disease (PD), Essential Tremor (ET) or Multiple Sclerosis (MS)
- Scheduled to undergo Deep Brain Stimulation (DBS) electrode implant or implanted pulse generator (IPG) replacement surgery
- Neurologically stable
- Able to understand the study and consent form
Exclusion Criteria:
- Inability to execute the motor tasks during the study
- Inability to tolerate withholding anti-parkinsonian and/or anti-tremor medications
- Clinically ineffective DBS
Sites / Locations
- University of Florida
- Emory University
- Duke University
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Therapeutic Stimulation Patterns
Symptogenic Stimulation Patterns
This group will receive temporal patterns of stimulation that are designed to suppress oscillatory neural activity at theta- or beta-frequencies. These patterns are hypothesized to alleviate motor symptoms.
This group will receive symptogenic patterns of stimulation that are designed to exacerbate oscillatory neural activity at theta- or beta-frequencies. These patterns are hypothesized to exacerbate motor symptoms.