RF Power, LSI and Oesophageal Temperature Alerts During AF Ablation (PiLOT-AF Study) (PiLOT-AF)
Atrial Fibrillation
About this trial
This is an interventional treatment trial for Atrial Fibrillation focused on measuring radiofrequency power, lesion size index, esophageal temperature alerts
Eligibility Criteria
Inclusion Criteria:
- male or female, aged 18 to 80 years;
- willing and able to give informed consent for participation in the study;
- history of symptomatic and drug-refractory atrial fibrillation;
- planned atrial fibrillation (AF) ablation on a clinical basis.
Exclusion Criteria:
- previous AF ablation;
- pregnancy, trying for a baby or breast feeding;
- oesophageal obstruction (mass, stricture), diverticulum or varices, tracheo-oesophageal fistula or any other oesophageal conditions prohibiting the use of oesophageal temperature probe for continuous luminal temperature monitoring;
- any other significant disease or disorder which, in the opinion of the investigator, may either put the participants at risk because of participation in the study, or may influence the result of the study, or the participant's ability to participate in the study.
Sites / Locations
- John Radcliffe Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Group "20 W / LSI 4"
Group "40 W / LSI 4"
Group "20 W / LSI 5"
Group "40 W / LSI 5"
Patients elected to atrial fibrillation (AF) ablation and randomized to Combination 1 of radiofrequency (RF) power and Lesion Size Index (LSI) on left atrial (LA) posterior wall
Patients elected to atrial fibrillation (AF) ablation and randomized to Combination 2 of radiofrequency (RF) power and Lesion Size Index (LSI) on left atrial (LA) posterior wall
Patients elected to atrial fibrillation (AF) ablation and randomized to Combination 3 of radiofrequency (RF) power and Lesion Size Index (LSI) on left atrial (LA) posterior wall
Patients elected to atrial fibrillation (AF) ablation and randomized to Combination 4 of radiofrequency (RF) power and Lesion Size Index (LSI) on left atrial (LA) posterior wall