Sirolimus Associated With Tacrolimus at Low Doses in Elderly Kidney Transplant Patients
Disorder Related to Renal Transplantation, Cytomegalovirus Infections
About this trial
This is an interventional treatment trial for Disorder Related to Renal Transplantation focused on measuring Kidney transplantation, sirolimus, cytomegalovirus, aged
Eligibility Criteria
Inclusion Criteria:
1. Patients aged more than 60 years and recipients of compatible renal transplant
Exclusion Criteria:
- Receptors of multiple organs;
- non-heart beating donors;
- donors aged under 5 or over 65 years;
- Patients with body mass index greater than 35
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Tacrolimus + Mycophenolate
Tacrolimus + Sirolimus
The investigators wil be used tacrolimus (starting with 0.1 mg/kg twice daily adjusted to target serum levels by 4-8ng/ml at the third month and then 3-7ng/ml from the third month to the 12th month) and mycophenolate sodium 720 mg twice daily. A dose reduction of mycophenolate sodium to 720 mg/day will be accepted due to possible side effects of the drug. Prednisone 30 mg/day in the first month. Induction therapy consisted of basiliximab or thymoglobulin if panel reactivity class I greater than 50 %
The investigators will be used tacrolimus (starting with 0.1 mg/kg twice daily adjusted to target serum levels by 4-8 ng/ml at the third month and then 3-7 ng/ml from the third month to the 12th month) and sirolimus 2 mg/day (adjusted serum levels at 4-8 ng/ml throughout the study period). Prednisone 30 mg/day in the first month. Induction therapy consisted of basiliximab or thymoglobulin if panel reactivity class I greater than 50 %