Role of Tranexamic Acid Versus Uterine Cooling at Caesarean Section
Hemorrhage of Cesarean Section and/or Perineal Wound, Postpartum Hemorrhage, Uterine Atony
About this trial
This is an interventional prevention trial for Hemorrhage of Cesarean Section and/or Perineal Wound focused on measuring Caesarean Section, Tranexamic Acid, Postpartum Hemorrhage, Ecbolics
Eligibility Criteria
Inclusion Criteria:
- Women who attended Talkha Central Hospital for planned or emergency secondary CS.
- Singleton pregnancy at term with gestational age (G.A) between 38±5 and 40 weeks.
Exclusion Criteria:
- Preoperative exclusion criteria were women who had any disorders of heart, liver, kidney, brain or blood, Abruptio placenta, placental abnormalities or accrete syndromes, Polyhydramnios, macrosomia, preeclampsia, allergy to TXA, history of thromboembolic disorders, or severe anemia.
- Intraoperative exclusion criteria was inability to exteriorize the uterus during CS for group (Y).
Sites / Locations
- Talkha Central Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Group (X) Prophylactic Tranexamic Acid
Group (Y) Intraoperative Uterine Cooling
Intravenously at 20 minutes preoperatively had an intervention of a single bolus TXA dose of 20•0 mg/kg, which was administered in Z solution (500•0 ml normal saline containing a prophylactic antibiotic 1•0 g) (NCT02739815).
Firstly intravenously at 20 minutes preoperatively had only the Z solution, and secondly [Intraoperatively immediately following delivery of the fetus the uterus was been externalized in the usual fashion, and the body of the uterus cephalad to the hysterotomy incision was been wrapped in sterile surgical towels saturated in sterile and iced normal saline. These towels came from a sterile cooling pot set to 30 degrees Fahrenheit. Iced saline-soaked towels was been kept in place for a minimum of 5 minutes and replaced at the discretion of the attending obstetrician until the hysterotomy is closed and the uterus is replaced into the patient's abdomen].