Second-Line Uterotonics in Postpartum Hemorrhage: A Randomized Clinical Trial
Postpartum HemorrhageUterine AtonyThe aim of this study is to evaluate in a randomized fashion the comparative efficacy of two second-line medications, methylergonovine and carboprost for treating atonic postpartum hemorrhage (PPH). The investigators hypothesize that administration of methylergonovine will produce superior uterine tone to carboprost in atonic PPH.
Perioperative Outcomes of Postpartum Hemorrhage in Patients Undergoing Cesarean Delivery
Cesarean Section ComplicationsPostpartum Hemorrhage3 morePostpartum haemorrhage is the common cause of maternal death worldwide. The primary purpose of this study is to identify the maternal outcomes after PPH. The highlighted outcome is the anesthetic management including rate of blood transfusion and incidence of patient experiencing massive blood transfusion. The secondary purposes of this study are amount of blood loss, causes of PPH and other outcomes that related to PPH such as the rate of hysterectomy and postoperative outcome eg. congestive heart failure, acute kidney injury and TRALI etc. Additionally, incidence of PPH will be studied. Data collection will be made to identify the cause of PPH, anesthetic techniques that may related to the amount of hemorrhage, medical treatment for PPH and neonatal outcomes. We also aim to obtain the rate of ICU admission and revealed the factors involving the ICU admission in PPH patients underwent cesarean delivery.
Comparison of Two Doses of Carbetocin for Prevention of Uterine Atony, During Elective Cesarean...
Uterine AtonyPost-partum HemorrhageThe purpose of this study is to evaluate the effectiveness of two doses of carbetocin (50 mcg vs 100 mcg) in preventing uterine atony during elective cesarean section.
Oxytocin And Uterotonic Agent Use For Cesarean Delivery
Uterine AtonyHypotensionThe central objective of this study will be to evaluate a standardized, evidence-based regimen versus a conventional regimen for uterotonic drug dosing for elective cesarean delivery The investigators primary hypothesis is that the proposed uterotonic drug regimen, when compared to conventional dosing regimen, during elective cesarean delivery will: 1. Reduce the overall amount of oxytocin and other uterotonic agents used to obtain satisfactory uterine tone. Secondary outcomes to be evaluated will be: Reduce the side effects associated with uterotonic drug use Reduce the time to establishment and maintenance of adequate uterine tone
The Comparison of the Effect of Different Oxytocin Administrations on the Blood Loss During Cesarean...
Cesarean Section ComplicationsPostpartum Hemorrhage7 moreThis study compares the effect of starting intravenous oxytocin infusion early before uterine incision versus late after umbilical cord clamping on the blood loss during elective cesarean section
Oxytocin Regimen to Prevent Atony and Postpartum Hemorrhage During Vaginal Delivery: 3-arm RCT
Uterine AtonyPostpartum HemorrhageThis is a double-blind 3-arm randomized clinical trial to determine whether higher dose oxytocin regimens (compared to the standard regimen) reduce the frequency of uterine atony and postpartum hemorrhage after vaginal delivery. Uterine atony is a loss of tone in the uterine musculature which can cause acute postpartum hemorrhage, which is the major cause of maternal mortality worldwide. Oxytocin is routinely administered postpartum in the US and effectively reduces uterine atony. The optimal dose of oxytocin for vaginal delivery is not known.
A Novel Technique Of Uterine Cooling During Repeated Cesarean Section For Reducing Blood Loss
Cesarean Section ComplicationsIntrapartum Hemorrhage3 moreStudy aim to evaluate the efficacy and safety of a novel technique of UTERINE COOLING during repeated cesarean section (CS) in reducing blood loss, and record any adverse effects following it.
Role of Tranexamic Acid Versus Uterine Cooling at Caesarean Section
Hemorrhage of Cesarean Section and/or Perineal WoundPostpartum Hemorrhage1 moreThis study aims to compare role of a prophylactic predefined intravenous Tranexamic Acid dose versus intraoperative Uterine Cooling in reducing blood loss and incidence of postpartum hemorrhage at secondary CS.
Up-Down Oxytocin Infusion
Uterine AtonyThis study is designed to determine the minimum effective dose (ED90) of infusions of oxytocin for the prevention of uterine atony / postpartum hemorrhage and the need for additional uterotonics, in low risk parturients presenting for an elective CD. The primary outcome measure is the response of effective uterine contraction as either satisfactory or unsatisfactory as determined by the obstetrician blinded to the oxytocin infusion dose. Secondary outcomes will include need for additional uterotonics, calculated intra-operative blood loss and presence of oxytocin related adverse effects.
An Evidence Based Protocol for Oxytocin Administration in Vaginal Delivery
Uterine AtonyPostpartum HemorrhageThe purpose of this study will be to evaluate a standardized, evidence-based protocol versus a conventional approach for the dosing of oxytocin in vaginal delivery.