Cognitive Training in Parkinson Study (cogtips)
Parkinson Disease, Impaired Cognition, Alteration in Cognition
About this trial
This is an interventional treatment trial for Parkinson Disease focused on measuring Parkinson, Cognitive training, Cognitive rehabilitation, Brain networks
Eligibility Criteria
--- Parkinson's disease patients ---
Inclusion Criteria:
- Subjective cognitive complaints, measured by the Parkinson's Disease Cognitive Functional Rating Scale score > 3 (PD-CFRS). A score above 3 indicates significant cognitive complaints, that are milder than complaints associated with Parkinson's disease dementia. This questionnaire is filled in by the patient.
- Participants' Hoehn & Yahr stage is lower than 4. Patients are stable on dopaminergic medication at least a month before starting the intervention. During the intervention, patient and neurologist will be asked to keep the dopaminergic medication dosage as stable as possible.
- Participants have access to a computer or tablet, with access to the Internet. If the participant uses a computer, he or she is capable of using a keyboard and computer mouse.
- Participants are willing to sign informed consent.
Exclusion Criteria:
General criteria:
- Indications for a dementia syndrome, measured by the Self-administered Gerocognitive Examination score < 14 or the Montreal Cognitive Assessment score < 22.
- Current drug- or alcohol abuse, measured by a score > 1 on the four CAGE AID-questions (according to the Trimbos guidelines).
- The inability to undergo extensive neuropsychological assessment, or eight weeks of intervention.
- Moderate to severe depressive symptoms, as defined by the Beck Depression Inventory score > 18.
- An impulse control disorder, including internet addiction, screened by the impulse control disorder criteria interview.
- Psychotic symptoms, screened by the Questionnaire for Psychotic Experiences. Benign hallucinations with insight are not contraindicated.
- Traumatic brain injury, only in case of a contusio cerebri with 1) loss of consciousness for > 15 minutes and 2) posttraumatic amnesia > 1 hour.
- A space occupying lesion defined by a radiologist, or significant vascular abnormalities (Fazekas > 1).
For participation in MRI research:
- Severe claustrophobia
- Metal in the body (for example, deep brain stimulator or pacemaker)
- Pregnancy
Problems with or shortness of breath during 60 minutes of lying still.
- Healthy control subjects ---
Inclusion criteria:
- Participants are willing to sign informed consent.
Exclusion criteria:
- Indications for a neurological disease, such as Parkinson's disease, Alzheimer's disease, mild cognitive impairment, multiple sclerosis or Huntington's disease;
- Indications for a dementia syndrome, measured by the Montreal Cognitive Assessment score < 22.
- Indications for a current stroke or CVA, or in the past.
- Indications for the presence of a psychotic or depressive disorder, measured with a positive screening on the SAPS-PD (benign hallucinations with insight are not contraindicated) and a BDI > 18 respectively.
- Current drug- or alcohol abuse, measured by a score > 1 on the four CAGE AID-questions (according to the Trimbos guidelines).
- The inability to undergo extensive neuropsychological assessment, or eight weeks of intervention.
- Traumatic brain injury, only in case of a contusio cerebri with 1) loss of conciousness for > 15 minutes and 2) posttraumatic amnesia > 1 hour.
- A space occupying lesion defined by a radiologist, or significant vascular abnormalities (Fazekas > 1).
- Contra-indications for participation in MRI scanning (see above)
Sites / Locations
- VU University Medical Center
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Active Comparator
No Intervention
Online cognitive training 1 (N=70)
Online cognitive training 2 (N=70)
Healthy control subjects (N=30)
Eight-week, three times a week during 45 minutes cognitive training
Eight-week, three times a week during 45 minutes cognitive activities
Reference group to compare cognitive training effects to