search
Back to results

Impact Evaluation of Urban Water Supply Improvements on Cholera and Other Diarrhoeal Diseases in Uvira, Democratic Republic of Congo

Primary Purpose

Cholera, Diarrhea

Status
Completed
Phase
Not Applicable
Locations
Congo, The Democratic Republic of the
Study Type
Interventional
Intervention
Improved water supply
Sponsored by
London School of Hygiene and Tropical Medicine
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional prevention trial for Cholera

Eligibility Criteria

undefined - undefined (Child, Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Uvira resident admitted to the Uvira Cholera Treatment Centre in Uvira

Exclusion Criteria:

  • Any patients admitted during the period of intervention implementation in each cluster

Sites / Locations

  • Centre de Traitement du Cholera, Hôpital General de Reference d'Uvira, Sud-Kivu, République Démocratique du Congo

Arms of the Study

Arm 1

Arm 2

Arm Type

No Intervention

Experimental

Arm Label

No intervention

Intervention

Arm Description

Current water supply access

Received water supply improvement intervention designed to improve access to tap water, consisting of community managed public taps, improved tap water distribution network, refurbished tap connections and promotion of new household tap connections.

Outcomes

Primary Outcome Measures

Admission rate to the Uvira Cholera Treatment Centre

Secondary Outcome Measures

Admission rate to the Uvira Cholera Treatment Centre of laboratory confirmed cholera cases

Full Information

First Posted
October 7, 2016
Last Updated
August 23, 2022
Sponsor
London School of Hygiene and Tropical Medicine
search

1. Study Identification

Unique Protocol Identification Number
NCT02928341
Brief Title
Impact Evaluation of Urban Water Supply Improvements on Cholera and Other Diarrhoeal Diseases in Uvira, Democratic Republic of Congo
Official Title
Impact Evaluation of Urban Water Supply Improvements on Cholera and Other Diarrhoeal in Uvira, Democratic Republic of Congo
Study Type
Interventional

2. Study Status

Record Verification Date
August 2022
Overall Recruitment Status
Completed
Study Start Date
October 2016 (Actual)
Primary Completion Date
December 31, 2021 (Actual)
Study Completion Date
December 31, 2021 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
London School of Hygiene and Tropical Medicine

4. Oversight

Data Monitoring Committee
No

5. Study Description

Brief Summary
The aim of the study is to evaluate the impact of a large-scale urban water supply improvement intervention on cholera and other diarrhoeal diseases. The study uses a step wedge cluster randomised controlled trial (SWcRCT) to measure the effect of the intervention on cholera centre admission rates and confirmed cholera cases. A nested cohort study will examine changes in water-related practices following the intervention.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Cholera, Diarrhea

7. Study Design

Primary Purpose
Prevention
Study Phase
Not Applicable
Interventional Study Model
Factorial Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
4556 (Actual)

8. Arms, Groups, and Interventions

Arm Title
No intervention
Arm Type
No Intervention
Arm Description
Current water supply access
Arm Title
Intervention
Arm Type
Experimental
Arm Description
Received water supply improvement intervention designed to improve access to tap water, consisting of community managed public taps, improved tap water distribution network, refurbished tap connections and promotion of new household tap connections.
Intervention Type
Other
Intervention Name(s)
Improved water supply
Primary Outcome Measure Information:
Title
Admission rate to the Uvira Cholera Treatment Centre
Time Frame
36 months
Secondary Outcome Measure Information:
Title
Admission rate to the Uvira Cholera Treatment Centre of laboratory confirmed cholera cases
Time Frame
36 months

10. Eligibility

Sex
All
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Uvira resident admitted to the Uvira Cholera Treatment Centre in Uvira Exclusion Criteria: Any patients admitted during the period of intervention implementation in each cluster
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Oliver Cumming, MSc
Organizational Affiliation
London School of Hygiene and Tropical Medicine
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Karin Gallandat, PhD
Organizational Affiliation
London School of Hygiene and Tropical Medicine
Official's Role
Principal Investigator
Facility Information:
Facility Name
Centre de Traitement du Cholera, Hôpital General de Reference d'Uvira, Sud-Kivu, République Démocratique du Congo
City
Uvira
State/Province
Sud-Kivu
Country
Congo, The Democratic Republic of the

12. IPD Sharing Statement

Plan to Share IPD
No
Citations:
PubMed Identifier
34154636
Citation
Gallandat K, Jeandron A, Ross I, Mufitini Saidi J, Bashige Rumedeka B, Lumami Kapepula V, Cousens S, Allen E, MacDougall A, Cumming O. The impact of improved water supply on cholera and diarrhoeal diseases in Uvira, Democratic Republic of the Congo: a protocol for a pragmatic stepped-wedge cluster randomised trial and economic evaluation. Trials. 2021 Jun 21;22(1):408. doi: 10.1186/s13063-021-05249-x.
Results Reference
derived
PubMed Identifier
33036564
Citation
Williams C, Cumming O, Grignard L, Rumedeka BB, Saidi JM, Grint D, Drakeley C, Jeandron A. Prevalence and diversity of enteric pathogens among cholera treatment centre patients with acute diarrhea in Uvira, Democratic Republic of Congo. BMC Infect Dis. 2020 Oct 9;20(1):741. doi: 10.1186/s12879-020-05454-0.
Results Reference
derived

Learn more about this trial

Impact Evaluation of Urban Water Supply Improvements on Cholera and Other Diarrhoeal Diseases in Uvira, Democratic Republic of Congo

We'll reach out to this number within 24 hrs